Stock Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2022

Stock Incentive Plans

Summary of stock option activity

				Weighted
		Weighted-		Average	Aggregate
		Average		Remaining	Intrinsic
		Exercise		Contractual	Value
	Shares	Price		Term (years)	(in thousands)
Outstanding at December 31, 2021	1,346,733	$	22.25	9.02	$	168
Granted	991,981	$	6.06
Exercised	(27,333)	$	3.03
Cancelled or forfeited	(56,818)	$	17.12
Expired	(1,132)	$	137.57
Outstanding at December 31, 2022	2,253,431	$	15.43	8.57	$	9,733
Vested and exercisable at December 31, 2022	615,382	$	28.74	7.79	$	705
Vested and expected to vest at December 31, 2022	2,253,431	$	15.43	8.57	$	9,733

Schedule of assumptions made based on the Black-Scholes option pricing model

	Year Ended December 31,
	2022	2021
Weighted-average expected volatility	65.60%-70.22	69.28-71.32%
Expected term (in years)	5.5-6.25	5-6.25
Risk-free interest rate	1.48%-4.17%	0.42-1.36%
Expected dividend yield	0%	0%