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Stock Incentive Plans - Stock options (Details) - Stock options - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Shares          
Outstanding, beginning of period (in shares)     1,346,733    
Granted (in shares)     944,481    
Exercised (in shares)     (16,202)    
Cancelled or forfeited (in shares)     (37,013)    
Expired (in shares)     (51)    
Outstanding, end of period (in shares) 2,237,948   2,237,948   1,346,733
Vested and exercisable (in shares) 551,774   551,774    
Weighted-Average Exercise Price          
Outstanding, beginning of period (in dollars per share)     $ 22.25    
Granted (in dollars per share)     5.83    
Exercised (in dollars per share)     2.10    
Cancelled or forfeited (in dollars per share)     21.87    
Expired (in dollars per share)     115.80    
Outstanding at end of year (in dollars per share) $ 15.47   15.47   $ 22.25
Vested and exercisable (in dollars per share) $ 30.09   $ 30.09    
Weighted Average Remaining Contractual Term (years)          
Outstanding     8 years 9 months 14 days   9 years 7 days
Vested and exercisable     7 years 11 months 19 days    
Aggregate Intrinsic Value          
Outstanding $ 3,292   $ 3,292   $ 168
Vested and exercisable 248   $ 248    
Stock Incentive Plans          
Number of options exercised (in shares)     16,202    
Intrinsic value of options exercised 129 $ 38 $ 129 $ 38  
Aggregate fair value of options vested $ 900 $ 300 $ 4,700 $ 1,300  
Weighted average grant date fair value of options granted (in dollars per share) $ 2.54 $ 6.20 $ 3.66 $ 10.15  
Unrecognized compensation expense related to unvested stock option awards $ 10,400   $ 10,400    
Weighted-average amortization period over which cost is expected to be recognized     2 years 7 months 6 days