Stock Incentive Plans - Stock options (Details) - Stock options - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Shares
Outstanding, beginning of period (in shares)			1,346,733
Granted (in shares)			796,481
Cancelled or forfeited (in shares)			(37,013)
Expired (in shares)			(51)
Outstanding, end of period (in shares)	2,106,150		2,106,150		1,346,733
Vested and exercisable (in shares)	485,217		485,217
Weighted-Average Exercise Price
Outstanding, beginning of period (in dollars per share)			$ 22.25
Granted (in dollars per share)			6.17
Cancelled or forfeited (in dollars per share)			21.87
Expired (in dollars per share)			115.80
Outstanding at end of year (in dollars per share)	$ 16.18		16.18		$ 22.25
Vested and Exercisable (in dollars per share)	$ 31.42		$ 31.42
Weighted Average Remaining Contractual Term (years)
Outstanding			8 years 11 months 15 days		9 years 7 days
Vested and Exercisable			8 years 1 month 20 days
Aggregate Intrinsic Value
Outstanding	$ 61		$ 61		$ 168
Vested and Exercisable	$ 61		$ 61
Stock Incentive Plans
Number of options exercised (in shares)	0	0	0	0
Aggregate fair value of options vested	$ 3,300	$ 400	$ 3,900	$ 1,000
Weighted average grant date fair value of options granted (in dollars per share)	$ 3.04	$ 10.38	$ 3.87	$ 10.38
Unrecognized compensation expense related to unvested stock option awards	$ 11,200		$ 11,200
Weighted-average amortization period over which cost is expected to be recognized			2 years 8 months 12 days