Stockholders' Equity - Common Stock Warrants (Details)	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Weighted Average
Common Stock Warrants
Weighted average life (in years)	4 years 18 days
Common stock warrants
Common Stock Warrants
Warrants Outstanding (in shares) | shares	1,530,380
Common stock warrants | Weighted Average
Common Stock Warrants
Exercise Price (in dollars per share) | $ / shares	$ 41.84
Warrants Issued in 2015 | Common stock warrants
Common Stock Warrants
Warrants Outstanding (in shares) | shares	204
Exercise Price (in dollars per share) | $ / shares	$ 732.72
Warrants Issued in 2018 | Common stock warrants
Common Stock Warrants
Warrants Outstanding (in shares) | shares	699,962
Exercise Price (in dollars per share) | $ / shares	$ 72.00
Warrants Issued in 2019 | Common stock warrants
Common Stock Warrants
Warrants Outstanding (in shares) | shares	331,858
Exercise Price (in dollars per share) | $ / shares	$ 37.50
Warrants Issued In 2021 | Common stock warrants
Common Stock Warrants
Warrants Outstanding (in shares) | shares	498,356
Exercise Price (in dollars per share) | $ / shares	$ 2.10