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Financial Instruments - Fair value hierarchy (Details) - USD ($)
$ / shares in Units, $ in Thousands
9 Months Ended
Sep. 30, 2021
Jun. 02, 2021
Jan. 28, 2021
Dec. 31, 2020
Sep. 30, 2020
Financial Instruments          
Fair value assets, transfers from Level 1 to Level 2 $ 0       $ 0
Fair value assets, transfers from Level 2 to Level 1 0       0
Fair value liabilities, transfers from Level 1 to Level 2 0       0
Fair value liabilities, transfers from Level 2 to Level 1 $ 0       $ 0
Common stock          
Financial Instruments          
Warrants to purchase number of shares   467,500      
Quellis Biosciences, Inc | Common stock          
Financial Instruments          
Warrants to purchase number of shares     30,856    
Exercise price of warrants (in dollars per share)   $ 2.10 $ 2.10    
Series X redeemable convertible preferred stock | Common stock          
Financial Instruments          
Exercise price of warrants (in dollars per share)   $ 2.10      
Series X redeemable convertible preferred stock | Quellis Biosciences, Inc          
Financial Instruments          
Warrants to purchase number of shares     2,805    
Exercise price of warrants (in dollars per share)     $ 341.70    
Reverse repurchase agreements | Government Securities and Obligations | Minimum          
Financial Instruments          
Percentage of investment amount to collateralized deposits value 102.00%        
Recurring          
Assets:          
Total assets $ 40,847     $ 42,999  
Recurring | Level 1          
Assets:          
Total assets 1,847     22,999  
Recurring | Level 2          
Assets:          
Total assets 39,000     20,000  
Recurring | Money market funds          
Assets:          
Cash and cash equivalents 1,847     22,999  
Recurring | Money market funds | Level 1          
Assets:          
Cash and cash equivalents 1,847     22,999  
Recurring | Reverse repurchase agreements          
Assets:          
Cash and cash equivalents 39,000        
Short-term investments       20,000  
Recurring | Reverse repurchase agreements | Level 2          
Assets:          
Cash and cash equivalents $ 39,000        
Short-term investments       $ 20,000