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Organization and Operations - Liquidity and Going Concern (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 9 Months Ended
Jun. 20, 2018
Oct. 31, 2017
Sep. 30, 2018
Dec. 31, 2017
Common Stock        
Accumulated deficit     $ (191,244) $ (171,434)
Cash, cash equivalents and short-term investments     $ 43,200  
Common Stock | Cowen        
Common Stock        
Percentage of commission paid to underwriter based on proceeds from common stock   0.03%    
Common Stock | First ATM Program | Cowen        
Common Stock        
Aggregate maximum offering amount   $ 10,000    
Common Stock | Second ATM Program        
Common Stock        
Number of shares issued     5,390,255  
Share price (in dollars per share)     $ 1.59  
Additional common stock issued     $ 8,600  
Net proceeds     $ 8,300  
Common Stock | June 2018 Financing | Oppenheimer & Co. Inc        
Common Stock        
Number of shares issued 42,000,000      
Share price (in dollars per share) $ 0.001      
Additional common stock issued $ 42,000      
Number of warrants to purchase 42,000,000      
Warrant purchase price per share $ 1.00      
Proceeds from public offering, net of issuance costs $ 38,900