UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.     )

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Catabasis Pharmaceuticals, Inc.
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
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*** Exercise Your Right to Vote *** Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on June 07, 2018 CATABASIS PHARMAACEUTICALS, INC. You are receiving this communication because you hold shares in the above named company. This is not a ballot. You cannot use this notice to vote t h ese shares. This communication p resents on l y an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy mater ia ls on line at www.proxyvote.com or easily request a paper copy (see reverse side). We encourage you to access and review all of the important information contained in the proxy materials before voting. CATA&-1515 PHARMACEUTICALS. I NC . One Kendall Square, Building 1400£ Suite 814202 Cambridge, MA 02139 See the reverse side of this notice to obtain proxy materials and voting instructions. Meeting Information Meeting Type: Annual Meeting For holders as of: April 1 2, 20 1 8 Date: June 07, 2018 Time: 10:00 AM EDT Location: The Offices of WilmerHale 60 State Street Boston. MA 02109

— Before You Vote — How to Access the Proxy Materials Proxy Materials Available to VIEW or RECEIVE: I. Notice & Proxy Statement 2. Annual Report How to View Online: Have the information that is printed in the box marked by the arrow —^ | xxxx xxxx xxxx xxxx] (located on the following page) and visit: www.proxyvote.com. How to Request and Receive a PAPER or E-MAIL Copy: If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request: BY INTERNET: www.proxyvote.com BY TELEPHONE: I -800-579-1 639 1)                            BY E-MAIL*:                                                sendmaterial@proxyvote.com * If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow —^ I XXXX XXXX XXXX XXXX (located on the following page) in the subject line. Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before May 24, 2018 to facilitate timely delivery. — How To Vote — Please Choose One of the Following Voting Methods Vote In Person: Many stockholder meetings have attendance requirements including, but not limited to, the possession of an attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any special "i requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. Vote By Internet: To vote now by lnternet,go to www.proxyvote.com. Have the information that is printed in the box 1            marked by the arrow XXXX XXXX XXXX XXXx available and follow the instructions. Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

Voting Items The Board of Directors recommends you vote FOR the following: 1. Election of Di rectors Nominees 1a Michael Ross, Ph.D. 1b Burt Adelman, M.D. The Board of Directors recommends you vote FOR the following proposal: 2. Ratification of the appointment of Ernst & Young L LP as our independent registered public accounting firm for the fiscal year ending December 31, 2018. NOTE: The shares represented by this proxy when properly executed will be voted in the manner directed herein by the undersigned stockholder(s). If no direct ion is made, this proxy will be voted FOR the election of the nominees listed in item 1 and FOR item 2. If any other matters properly come before the meeting, the persons named in t his proxy will vote in their discretion.

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