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Stock-based compensation (Details 3) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 30, 2015
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Stock based compensation          
Stock-based compensation expense   $ 488 $ 232 $ 1,143 $ 605
Research and development          
Stock based compensation          
Stock-based compensation expense   173 100 505 289
General and administrative          
Stock based compensation          
Stock-based compensation expense   $ 315 $ 132 $ 638 $ 316
Employee Stock Purchase Plan          
Stock based compensation          
Shares available for grant (in shares) 182,352        
Annual minimum increase | Employee Stock Purchase Plan          
Stock based compensation          
Percentage of outstanding Common Stock available for issuance (as a percent) 1.00%        
Potential increase in shares available for issuance as determined by the Board of Directors (in shares) 364,705