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Accrued Expenses (Tables)
12 Months Ended
Dec. 31, 2017
Payables and Accruals [Abstract]  
Schedule of Accrued Expenses
Accrued expenses consist of the following (in thousands):
 
December 31,
 
December 31,
 
2017
 
2016
Payroll and employee related expenses
$
1,902

 
$
1,551

Current portion of deferred rent and lease incentive
72

 
29

Collaboration and licensing
1,020

 

Accrued patent fees
268

 
415

Accrued external research and development costs
3,578

 
794

Accrued professional and consulting services
859

 
459

Accrued grant refund
175

 
152

Accrued interest
89

 
81

Other
617

 
440

     Accrued expenses
$
8,580


$
3,921