Exhibit 15.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statement (Form F-3 No. 333-166697) of Seanergy Maritime Holdings Corp.,

(2) Registration Statement (Form F-3 No. 333-169813) of Seanergy Maritime Holdings Corp.,

(3) Registration Statement (Form F-3 No. 333-214967) of Seanergy Maritime Holdings Corp.,

(4) Registration Statement (Form F-3 No. 333-226796) of Seanergy Maritime Holdings Corp.;

(5) Registration Statement (Form F-3 No. 333-221058) of Seanergy Maritime Holdings Corp.,

(6) Registration Statement (Form F-3 No. 333-237500) of Seanergy Maritime Holdings Corp., and

(7) Registration Statement (Form F-3 No. 333-238136) of Seanergy Maritime Holdings Corp.

of our report dated March 31, 2021, with respect to the consolidated financial statements of Seanergy Maritime Holdings Corp. included in this Annual Report (Form 20-F) of Seanergy Maritime Holdings Corp. for the year ended December 31, 2020.

/s/ Ernst & Young (Hellas) Certified Auditors Accountants S.A.

Athens, Greece

March 31, 2021