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                            March 1, 2021

       Stamatios Tsantanis
       Chief Executive Officer
       Seanergy Maritime Holdings Corp.
       154 Vouliagmenis Avenue
       166 74 Glyfada
       Athens, Greece

                                                        Re: Seanergy Maritime
Holdings Corp.
                                                            Registration
Statement on Form F-1
                                                            Filed February 22,
2021
                                                            File No. 333-253332

       Dear Mr. Tsantanis:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Karina
Dorin, Staff Attorney, at (202) 551-3763 with any questions.




                            Sincerely,


                            Division of Corporation Finance

                            Office of Energy & Transportation
       cc:                                              Will Vogel