Wilson Sonsini Goodrich & Rosati Professional Corporation   650 Page Mill Road Palo Alto, California 94304-1050   O: 650.493.9300 F: 650.493.6811

May 2, 2023

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Technology

100 F Street, N.E.

Washington, D.C. 20549

Attention: Inessa Kessman

Lisa Etheredge

Re: Twilio Inc.

Current Report on Form 8-K Filed February 13, 2023

File No. 001-37806

Dear Ms. Kessman and Ms. Etheredge:

In the comment letter (the “Comment Letter”) of the staff of the Securities and Exchange Commission (the “Staff”) dated April 5, 2023, the Staff requested that Twilio Inc. (the “Company”) respond to the Staff’s comments regarding the above referenced Form 8-K (File No. 001-37806) within ten business days of receipt of the Comment Letter.

Pursuant to the Company’s request by telephone conference with Inessa Kessman on May 2, 2023, the Company requests an extension of an additional seven business days so that the Company may devote the appropriate amount of time and resources to ensure a sufficient response. The Company plans to provide a response to the Comment Letter on or before May 12, 2023.

Please do not hesitate to call me at (650) 430-1175 with any questions.

Sincerely,

WILSON SONSINI GOODRICH & ROSATI

Professional Corporation

/r/ Rezwan D. Pavri

Rezwan D. Pavri

cc: Aidan Viggiano, Twilio Inc.

Dana Wagner, Twilio Inc.

Juliana Chen, Twilio Inc.

Nate Troup, Twilio Inc.

Colin Conklin, Wilson Sonsini Goodrich & Rosati, P.C.

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