Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenue
Total revenue	$ 1,587	$ 6,892	$ 4,267	$ 8,166
Expenses
Research, development, collaborations and contracts	16,566	15,537	46,871	44,854
General and administrative	2,631	3,659	10,075	12,586
Depreciation of property and equipment	497	593	1,677	1,407
Total site consolidation expense	(492)	0	3,710	0
Impairment of intangible assets	14,811	0	14,811	0
Total expenses	34,013	19,789	77,144	58,847
Loss from operations	(32,426)	(12,897)	(72,877)	(50,681)
Other income (loss)
Interest income	756	337	2,319	1,095
Interest expense	0	(76)	(104)	(186)
Foreign exchange (loss) gain	145	1,233	(740)	2,458
Gain on equity investment	0	0	24,884	0
Equity investment loss	(2,838)	0	(2,838)	0
Increase in fair value of warrant liability	0	0	0	(22)
Decrease (increase) in fair value of contingent consideration	5,608	(197)	6,263	(1,146)
Total other income	3,671	1,297	29,784	2,199
Net (loss) before income taxes	(28,755)	(11,600)	(43,093)	(48,482)
Income tax benefit	4,282	0	4,282	0
Net (loss)	(24,473)	(11,600)	(38,811)	(48,482)
Accrual of coupon on convertible preferred shares	(2,567)	0	(7,444)	0
Net (loss) attributable to common shares	$ (27,040)	$ (11,600)	$ (46,255)	$ (48,482)
Net (loss) attributable to common shareholders, per share (note 2)
Basic and diluted (in dollars per share)	$ (0.49)	$ (0.21)	$ (0.84)	$ (0.89)
Weighted average number of common shares
Weighted average number of common shares basic and diluted (in shares)	55,421,504	54,877,103	55,241,284	54,612,081