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Equity method investment - Narrative (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Apr. 11, 2018
Sep. 30, 2018
Jun. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Schedule of Equity Method Investments [Line Items]            
Gain on investments   $ 0   $ 0 $ 24,884 $ 0
Goodwill transfer to equity method investment   (1,893)        
Genevant Sciences Corporation            
Schedule of Equity Method Investments [Line Items]            
Investment in Genevant $ 600 $ 0     $ 27,377  
Ownership interest in equity method investment 50.00% 40.00%     40.00%  
Gain on investments     $ 24,884      
Goodwill transfer to equity method investment $ 1,893          
Roivant Sciences Ltd | Genevant Sciences Corporation            
Schedule of Equity Method Investments [Line Items]            
Investment in Genevant 37,500          
Investment in Genevant 22,500          
Commitment to contribute to equity method investment $ 15,000