Consolidated Statement of Stockholders’ Equity - USD ($) $ in Thousands	Total	Common Shares	Additional paid-in capital	Deficit	Accumulated other comprehensive loss
Shares, Issued, Beginning Balance at Dec. 31, 2021		144,987,736
Beginning balance at Dec. 31, 2021	$ 169,439	$ 1,286,636	$ 65,485	$ (1,134,347)	$ (48,335)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	7,182		7,182
Certain fair value adjustments to liability stock option awards	26		26
Issuance of common shares pursuant to the Open Market Sales Agreement (in shares)		8,645,426
Issuance of common shares pursuant to the Open Market Sales Agreement	$ 20,324	$ 20,324
Issuance of common shares pursuant to exercise of ESPP options (in shares)	171,224	171,224
Issuance of common shares pursuant to exercise of ESPP	$ 395	$ 588	(193)
Issuance of common shares pursuant to Share Purchase Agreement (in shares)		3,579,952
Issuance of common shares pursuant to exercise of stock options	10,973	$ 10,973
Issuance of common shares pursuant to exercise of options (in shares)		71,025
Issuance of common shares pursuant to exercise of stock options	122	$ 216	(94)
Unrealized gain (loss) on available-for-sale securities	(2,153)				(2,153)
Net loss	(69,456)			(69,456)
Ending balance (in shares) at Dec. 31, 2022		157,455,363
Ending balance at Dec. 31, 2022	136,852	$ 1,318,737	72,406	(1,203,803)	(50,488)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	9,301		9,301
Issuance of common shares pursuant to the Open Market Sales Agreement (in shares)		12,020,257
Issuance of common shares pursuant to the Open Market Sales Agreement	$ 29,852	$ 29,852
Issuance of common shares pursuant to exercise of ESPP options (in shares)	290,438	290,438
Issuance of common shares pursuant to exercise of ESPP	$ 535	$ 774	(239)
Issuance of common shares pursuant to exercise of options (in shares)		101,356
Issuance of common shares pursuant to exercise of stock options	260	$ 458	(198)
Unrealized gain (loss) on available-for-sale securities	2,067				2,067
Net loss	(72,849)			(72,849)
Ending balance (in shares) at Dec. 31, 2023		169,867,414
Ending balance at Dec. 31, 2023	$ 106,018	$ 1,349,821	$ 81,270	$ (1,276,652)	$ (48,421)