Shareholders’ equity (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Oct. 22, 2023	Mar. 03, 2022	Nov. 04, 2021	Oct. 08, 2021	Mar. 04, 2021	Oct. 22, 2020	Aug. 07, 2020	Jan. 10, 2020
Class of Stock [Line Items]
Preferred stock, shares authorized (in shares)	1,164,000
Stock Option
Class of Stock [Line Items]
Number of additional shares authorized (in shares)	7,672,299
Common Shares | Jan 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price										$ 150,000
Common Shares | Oct 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price								$ 200,000
Common Shares | Nov 2021 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price					$ 250,000
Jefferies LLC | Common Shares | October 2021 Prospectus Supplement | Oct 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price						$ 75,000
Common Stock, Value, Subscriptions Expired			$ 29,300
Jefferies LLC | Common Shares | Sale Agreement
Class of Stock [Line Items]
Number of shares issued under agreement	12,020,257	8,645,426
Proceeds from issuance of common stock	$ 29,900	$ 20,300
Jefferies LLC | Common Shares | Aug 2020 Prospectus Supplement | Jan 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price									$ 75,000
Jefferies LLC | Common Shares | Mar 2021 Prospectus Supplement Agreement | Oct 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price							$ 75,000
Jefferies LLC | Common Shares | March 2022 Prospectus Supplement
Class of Stock [Line Items]
Aggregate share sales price	70,900
Jefferies LLC | Common Shares | March 2022 Prospectus Supplement | Jan 2020 Oct 2020 and Nov 2021 Registration Stmts
Class of Stock [Line Items]
Aggregate share sales price				$ 100,000
Jefferies LLC | Common Shares | Jan 2020 Prospectus Supplement | Jan 2020 Registration Stmt
Class of Stock [Line Items]
Aggregate share sales price										$ 50,000
Qilu Pharmaceutical Co, LTD.
Class of Stock [Line Items]
Income Taxes Paid	$ 4,400	$ 4,400