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Accounts payable and accrued liabilities
 12 Months Ended
Dec. 31, 2023
Payables and Accruals [Abstract]  
Accounts payable and accrued liabilities Accounts payable and accrued liabilities
 
Accounts payable and accrued liabilities are comprised of the following:
 December 31, 2023December 31, 2022
(in thousands)
Trade accounts payable$3,223 $3,520 
Payroll accruals3,349 3,730 
Research and development accruals2,884 8,261 
Professional fee accruals815 512 
Other accrued liabilities— 6 
Total$10,271 $16,029 
 
In connection with the Company’s decision in September 2023 to focus its pipeline on its HBV clinical stage compounds and discontinue certain research programs, the Company took steps to streamline the organization and reduced its workforce by 24% in November 2023, primarily affecting the research function. As a result, the Company incurred a one-time restructuring charge of approximately $1.1 million in the fourth quarter 2023, of which $0.2 million was accrued and included in payroll accruals as of December 31, 2023.