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Related party transactions (Details)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2020
USD ($)
ft²
Dec. 31, 2020
USD ($)
ft²
Dec. 31, 2019
USD ($)
Jul. 31, 2020
USD ($)
Related Party Transaction [Line Items]        
Gain (loss) on investments   $ (2,545) $ (22,522)  
Genevant        
Related Party Transaction [Line Items]        
Investments       $ 2,500
Gain (loss) on investments $ 2,500   (14,900)  
Genevant | Equity Method Investee | Administrative and transitional services        
Related Party Transaction [Line Items]        
Income from related party   100 $ 100  
Genevant | Equity Method Investee | Sublease Burnaby facility        
Related Party Transaction [Line Items]        
Income from related party   $ 200    
Area of sublease facility | ft² 17,900 17,900