Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Revenue
Total revenue	$ 6,011	$ 5,945
Non-cash royalty revenue	(1,656)	0
Operating expenses
Research and development	57,601	57,934
General and administrative	17,727	16,002
Depreciation	2,028	2,181
Site consolidation	156	4,797
Impairment of intangible assets	43,836	14,811
Impairment of goodwill	22,471	0
Legal Fees	6,266	0
Total operating expenses	150,085	95,725
Loss from operations	(144,074)	(89,780)
Other income (loss)
Interest income	2,111	3,047
Interest expense	(2,108)	(226)
Other income - Net equity investment gain or loss	(22,522)	19,322
Decrease in fair value of contingent consideration	173	7,298
Foreign exchange gains (losses)	41	(1,003)
Total other income (loss)	(22,305)	28,438
Loss before income taxes	(166,379)	(61,342)
Income tax benefit	12,656	4,282
Net loss	(153,723)	(57,060)
Items applicable to preferred shares
Dividend accretion of convertible preferred shares	(11,149)	(10,091)
Net loss attributable to common shares	$ (164,872)	$ (67,151)
Earnings Per Share, Basic and Diluted	$ (2.89)	$ (1.21)
Comprehensive income
Currency translation adjustment	$ (59)	$ 15
Comprehensive loss	(153,782)	(57,045)
Common Shares
Items applicable to preferred shares
Dividend accretion of convertible preferred shares	0	0
Net loss attributable to common shares	$ (164,872)	$ (67,151)
Earnings Per Share, Basic and Diluted	$ (2.89)	$ (1.21)
Weighted average number of common shares
Basic and diluted	57,093,454	55,304,083
Collaboration And Contracts [Member]
Revenue
Total revenue	$ 4,355	$ 5,945
OMERS
Revenue
Non-cash royalty revenue	$ 1,656