Accounts Payable and Accrued Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Payables and Accruals [Abstract]
Trade accounts payable	$ 3,192	$ 1,987
Payroll accruals	2,341	2,893
Research and development accruals	2,716	4,937
Professional fee accruals	871	429
Deferred lease inducements	0	42
Other accrued liabilities	309	358
Accounts payable and accrued liabilities	$ 9,429	$ 10,646