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Employee Stock Benefit Plans (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Share-based compensation is reflected in the condensed consolidated statements of operations
Share-based compensation	$ 4,817	$ 4,056	$ 10,092	$ 7,777
Research and development
Share-based compensation is reflected in the condensed consolidated statements of operations
Share-based compensation	2,701	2,077	4,925	4,028
Selling, general and administrative
Share-based compensation is reflected in the condensed consolidated statements of operations
Share-based compensation	$ 2,116	$ 1,979	$ 5,167	$ 3,749

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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