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Note 5 - Stockholders' Equity, Stock Options and Warrants (Tables)
3 Months Ended
Mar. 31, 2022
Notes Tables  
Share-Based Payment Arrangement, Activity [Table Text Block]
  

Stock Options

  

Warrants

 
  

Number of
Shares

  

Average
Exercise
Price

  

Number of
Shares

  

Average
Exercise
Price

 

Outstanding at December 31, 2020

  1,013,547  $5.41   7,353,376  $1.99 
                 

Issued

  147,230   1.06   29,640,801   1.44 

Forfeited

  (92,593

)

  8.64   -   - 

Expired

  -   -   (25,233

)

  10.00 

Exercised

  (5,313

)

  0.74   (5,269,059

)

  0.86 

Outstanding at December 31, 2021

  1,062,871  $4.83   31,699,885  $1.66 
                 

Issued

  4,175   1.08   -   1.44 

Forfeited

  -   9.27   -   - 

Expired

  (36,467)  15.18   (38,640)  26.91 

Outstanding at March 31, 2022

  1,030,579  $4.51   31,661,245  $1.63