Exhibit 12.1

Skyline Medical Inc.

Computation of Ratio of Earnings to Fixed Charges

	Six Months ended
	June 30,			Year ended December 31,
	2016			2015			2014			2013			2012			2011
Determination of earnings
Loss before income taxes	$	(4,737,650	)	$	(4,790,530	)	$	(6,833,568	)	$	(9,406,304	)	$	(7,422,155	)	$	(4,486,878	)
Add:
Fixed charges - per below		-			407,305			377,733			636,736			259,350			230,374
Total loss		(4,737,650	)		(4,383,225	)		(6,455,835	)		(8,769,568	)		(7,162,805	)		(4,256,504	)
Fixed charges:
Interest expense		-			188,208			130,395			636,736			259,350			230,374
Original Issue Discount		-			219,097			247,338
Total Fixed charges		-			407,305			377,733			636,736			259,350			230,374
Ratio of earnings to fixed
charges (1)
Deficiency of earnings to
cover fixed charges	$	4,737,650		$	4,790,530		$	6,833,568		$	9,406,304		$	7,422,155		$	4,486,878

(1) For all periods presented, no ratios are provided as earnings were insufficient to cover fixed charges.