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Document and Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2019
Mar. 06, 2020
Jun. 30, 2019
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2019    
Document Fiscal Year Focus 2019    
Document Fiscal Period Focus FY    
Trading Symbol PTI    
Entity Registrant Name PROTEOSTASIS THERAPEUTICS, INC.    
Entity Central Index Key 0001445283    
Current Fiscal Year End Date --12-31    
Entity Filer Category Accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company true    
Title of 12(b) Security Common stock, $0.001    
Security Exchange Name NASDAQ    
Entity Ex Transition Period true    
Entity Shell Company false    
Entity Well-known Seasoned Issuer No    
Entity Current Reporting Status Yes    
Entity Voluntary Filers No    
Entity Interactive Data Current Yes    
Entity Common Stock, Shares Outstanding   52,147,656  
Entity File Number 001-37695    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 20-8436652    
Document Annual Report true    
Document Transition Report false    
Entity Address, Address Line One 80 Guest Street    
Entity Address, Address Line Two Suite 500    
Entity Address, City or Town Boston    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02135    
City Area Code 617    
Local Phone Number 225-0096    
Entity Public Float     $ 46,857,063
Documents Incorporated by Reference

Portions of the registrant’s definitive Proxy Statement for its 2020 Annual Meeting of Stockholders are incorporated by reference into Part III of this Annual Report on Form 10-K.