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Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($)
$ in Thousands
Jun. 30, 2018
Dec. 31, 2017
Payables And Accruals [Abstract]    
Accrued payroll and related expenses $ 1,704 $ 1,542
Accrued research and development expenses 4,227 3,930
Accrued professional fees 283 556
Accrued other 308 92
Total accrued expenses $ 6,522 $ 6,120