DEF 14A 1 tm242716-1_def14a.htm SCHEDULE 14A tm242716-1_def14a - none - 13.343797s
 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.  )
Filed by the Registrant   ☒
Filed by a Party other than the Registrant   ☐
Check the appropriate box:

Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under §240.14a-12
MERSANA THERAPEUTICS, INC.
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
Payment of Filing Fee (Check the appropriate box):

No fee required.

Fee paid previously with preliminary materials.

Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.
 

 
MERSANA THERAPEUTICS, INC.
840 Memorial Drive
Cambridge, Massachusetts 02139
April 26, 2024
To Our Stockholders:
You are cordially invited to attend the 2024 Annual Meeting of Stockholders of Mersana Therapeutics, Inc., or the Annual Meeting, to be held at 9:00 a.m., Eastern Time, on Tuesday, June 11, 2024. The Annual Meeting will be a completely virtual meeting and will be conducted via live webcast. There will not be a physical location for the Annual Meeting, and you will not be able to attend the Annual Meeting in person. You will be able to attend the Annual Meeting online and submit your questions during the meeting by visiting www.virtualshareholdermeeting.com/MRSN2024.
The Notice of Annual Meeting and proxy statement on the following pages describe the matters to be presented at the Annual Meeting. Details regarding how to attend the meeting and the business to be conducted at the Annual Meeting are more fully described in the Notice of 2024 Annual Meeting of Stockholders and proxy statement.
It is important that your shares be represented at the Annual Meeting. Whether or not you plan to attend the meeting online, we hope that you will have your stock represented by voting your shares over the internet, by telephone or, if you have requested to receive paper copies of these materials, by completing, signing, dating and returning the enclosed proxy card in the enclosed envelope, prior to the Annual Meeting. If you receive our Notice of Internet Availability of Proxy Materials, then instructions regarding how you can vote are contained in that notice. If you have requested to receive a proxy card, then instructions regarding how you can vote are contained on the proxy card. If your shares are held by a bank, broker or other agent, you will receive voting instructions from such bank, broker or other agent that you must follow for your shares to be voted. If you decide to attend the Annual Meeting, you will be able to vote your shares electronically, even if you have previously submitted your proxy.
Thank you for your continued support.
Sincerely,
[MISSING IMAGE: sg_martinhuber-bw.jpg]
Martin Huber, M.D.
President, Chief Executive Officer and Director
 

 
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MERSANA THERAPEUTICS, INC.
840 Memorial Drive
Cambridge, Massachusetts 02139
NOTICE OF 2024 ANNUAL MEETING OF STOCKHOLDERS
To Be Held on June 11, 2024
To Our Stockholders:
NOTICE IS HEREBY GIVEN that the 2024 Annual Meeting of Stockholders, or the Annual Meeting, of Mersana Therapeutics, Inc., a Delaware corporation, or Mersana or the Company, will be held on Tuesday, June 11, 2024, at 9:00 a.m. ET. The Annual Meeting will be a completely virtual meeting and will be conducted via live webcast. Stockholders can attend the meeting via the internet at www.virtualshareholdermeeting.com/MRSN2024 and submit questions and vote shares electronically at the Annual Meeting.
The Annual Meeting is called for the following purposes:
1.
To elect two Class I directors to serve until our 2027 annual meeting of stockholders and until their respective successors have been duly elected and qualified;
2.
To approve, on a non-binding, advisory basis, the compensation of our named executive officers, as disclosed in our proxy statement;
3.
To ratify the selection of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024; and
4.
To transact any other business that may properly come before the Annual Meeting or any adjournment or postponement thereof.
You can find more information regarding the foregoing in the attached proxy statement.
Each outstanding share of Mersana’s common stock (Nasdaq: MRSN) entitles the holder of record at the close of business on April 15, 2024, to receive notice of, and to vote at, the Annual Meeting or any adjournment or postponement of the Annual Meeting. A complete list of these stockholders will be available for examination by any stockholder during the ten days prior to the Annual Meeting for a purpose germane to the meeting at our offices at 840 Memorial Drive, Cambridge, Massachusetts 02139.
Instead of mailing a paper copy of our proxy materials to all of our stockholders, we are providing access to our proxy materials via the internet under the “notice and access” rules of the Securities and Exchange Commission. As a result, we are sending to our stockholders a Notice of Internet Availability of Proxy Materials, instead of a paper copy of this proxy statement and our annual report to stockholders for the fiscal year ended December 31, 2023, or the 2023 Annual Report. We plan to mail the Notice of Internet Availability of Proxy Materials on or about April 26, 2024, and the Notice of Internet Availability of Proxy Materials contains instructions on how to access our proxy materials over the internet and how each of our stockholders can receive a paper copy of the proxy materials, including the proxy statement, our 2023 Annual Report and a form of proxy card.
Your vote is important. Whether or not you expect to attend the virtual Annual Meeting, please vote by telephone or through the internet or, if you receive a paper proxy card by mail, by completing, signing, dating and returning the proxy card mailed to you, as promptly as possible in order to ensure your representation at the Annual Meeting. Voting instructions are provided in the Notice of Internet Availability of Proxy Materials, or, if you receive a paper proxy card by mail, the instructions are printed on your proxy card and included in the
 

 
accompanying proxy statement. Even if you have voted by proxy, if you attend the Annual Meeting, you may still vote online during the Annual Meeting. Please note, however, that if your shares are held of record by a bank, brokerage firm or other agent and you wish to vote online at the Annual Meeting, you must obtain a proxy issued in your name from that agent in order to vote your shares that are held in such agent’s name and account.
By Order of the Board of Directors
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Alejandra Carvajal
Secretary
Cambridge, Massachusetts
April 26, 2024
 

 
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MERSANA THERAPEUTICS, INC.
840 Memorial Drive
Cambridge, Massachusetts 02139
PROXY STATEMENT
For the 2024 Annual Meeting of Stockholders
To Be Held on Tuesday, June 11, 2024 at 9:00 A.M. ET
This proxy statement, along with the accompanying Notice of 2024 Annual Meeting of Stockholders, is being furnished in connection with the solicitation of proxies by the Board of Directors of Mersana Therapeutics, Inc. for use at the 2024 Annual Meeting of Stockholders of Mersana Therapeutics, Inc., to be held at 9:00 a.m. ET via a live webcast at www.virtualshareholdermeeting.com/MRSN2024, including any postponement or adjournment thereof, which we refer to as the Annual Meeting.
In this proxy statement, we refer to Mersana Therapeutics, Inc. as “Mersana,” “the Company,” “we,” and “us.”
Important Notice Regarding the Availability of Proxy Materials
for the Annual Meeting of Stockholders to Be Held on June 11, 2024:
This proxy statement and our 2023 Annual Report to Stockholders, or the 2023 Annual Report, are available for viewing, printing and downloading at www.proxyvote.com. To view these materials, please have your 16-digit control number(s) available that appears on your proxy card.
A copy of our Annual Report on Form 10-K for the fiscal year ended December 31, 2023, as filed with the Securities and Exchange Commission, or the SEC, except for exhibits, will be furnished without charge to any stockholder upon written request to: Mersana Therapeutics, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139, Attention: Secretary. Exhibits, if any, will be provided upon written request and payment of an appropriate processing fee. This proxy statement and our 2023 Annual Report are also available on the SEC’s website at http://www.sec.gov.
On or about April 26, 2024, we intend to mail a Notice of Internet Availability of Proxy Materials, or the Notice, to our stockholders (other than those who previously requested electronic or paper delivery of proxy materials), directing stockholders to a website where they can access our proxy materials, including this proxy statement and our 2023 Annual Report, and view instructions on how to vote online or by telephone. If you would prefer to receive a paper copy of our proxy materials, please follow the instructions included in the Notice. If you have previously elected to receive our proxy materials electronically, you will continue to receive access to those materials via e-mail unless you elect otherwise.
 
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QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING
Q:
What is the purpose of this proxy statement?
A:
We are sending you this proxy statement because the Board of Directors of Mersana is inviting you to vote (by soliciting your proxy) at our 2024 Annual Meeting of Stockholders to be held at 9:00 a.m. ET on Tuesday, June 11, 2024, via a live webcast at www.virtualshareholdermeeting.com/MRSN2024, including any adjournments or postponements of the meeting, which we refer to as the Annual Meeting. This proxy statement, along with the accompanying Notice of 2024 Annual Meeting of Stockholders, summarizes the purposes of the Annual Meeting and information that is intended to assist you in making an informed vote on the proposals described in this proxy statement.
Q:
Why did I receive a one-page notice regarding the internet availability of proxy materials instead of a full set of proxy materials?
A:
Pursuant to rules adopted by the SEC, we are providing access to our proxy materials over the internet, which reduces both the costs and the environmental impact of sending our proxy materials to stockholders. We intend to mail a Notice of Internet Availability of Proxy Materials, or the Notice, to our stockholders (other than those who previously requested paper copies) on or about April 26, 2024.
The Notice contains instructions on how to:

access and view the proxy materials over the internet;

vote; and

request a paper or e-mail copy of the proxy materials.
In addition, if you received paper copies of our proxy materials and wish to receive all future proxy materials, proxy cards and annual reports electronically, please follow the electronic delivery instructions on www.proxyvote.com. We encourage stockholders to take advantage of the availability of the proxy materials on the internet to help reduce the cost and environmental impact of the Annual Meeting.
Q:
How do I attend the Annual Meeting?
A:
Our Annual Meeting will be held in a virtual meeting format at www.virtualshareholdermeeting.com/MRSN2024. To participate in the Annual Meeting, you will need the 16-digit control number included in your Notice, on your proxy card or on the instructions that accompanied your proxy materials. The meeting webcast will begin promptly at 9:00 a.m. ET. We encourage you to access the meeting prior to the start time. Online check-in will start 15 minutes before the meeting begins, and you should allow ample time for the check-in procedures. If your shares are held in a bank or brokerage account, instructions should also be provided on the voting instruction form provided by your bank or brokerage firm. Stockholders who wish to submit questions related to the business of the Annual Meeting may do so electronically starting at the time of check-in or during the meeting by clicking the option in the virtual meeting webcast portal. If you lose your 16-digit control number, you may join the Annual Meeting as a “Guest,” but you will not be able to vote or ask questions.
Q:
Who can vote at the Annual Meeting?
A:
Only stockholders of record at the close of business on April 15, 2024, or the Record Date, will be entitled to vote at the Annual Meeting. On the Record Date, there were 122,361,236 shares of common stock outstanding and entitled to vote. A list of stockholders entitled to vote at the Annual Meeting will be available at our offices at 840 Memorial Drive, Cambridge, Massachusetts 02139 during normal business hours for examination by any stockholder for any purpose germane to the meeting for ten days prior to the Annual Meeting.
Stockholder of Record: Shares Registered in Your Name
If on the Record Date your shares were registered directly in your name with our transfer agent, Computershare Trust Company, N.A., then you are a stockholder of record. As a stockholder of record,
 
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you may vote online at the Annual Meeting or vote by proxy. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy electronically through the internet, over the telephone or by completing and returning a printed proxy card that you may request or that we may elect to deliver at a later time to ensure your vote is counted.
Beneficial Owner: Shares Registered in the Name of a Bank or Broker
If on the Record Date your shares were held not in your name but rather in an account at a bank, brokerage firm or other similar organization, then you are the beneficial owner of shares held in “street name” and the Notice is being forwarded to you by that organization. The organization holding your account is considered to be the stockholder of record for purposes of voting at the Annual Meeting. As a beneficial owner, you have the right to direct your bank, broker or other agent regarding how to vote the shares in your account. You are also invited to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote your shares online during the Annual Meeting unless you request and obtain a valid proxy from your bank, broker or other agent.
Q:
On what matters am I voting?
A:
There are three matters scheduled for a vote:

Election of two Class I directors to serve until our 2027 annual meeting of stockholders and until their respective successors have been duly elected and qualified (Proposal 1);

Approval, on a non-binding, advisory basis, of the compensation of our named executive officers, as disclosed in our proxy statement (commonly referred to as “Say-on-Pay”) (Proposal 2); and

Ratification of the selection of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024 (Proposal 3).
Q:
What if another matter is properly brought before the Annual Meeting?
A:
The Board of Directors knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the meeting, it is the intention of the persons named in the accompanying proxy to vote on those matters in accordance with their best judgment.
Q:
How do I vote?
A:
The procedures for voting are fairly simple:
Stockholder of Record: Shares Registered in Your Name
If you are a stockholder of record, you may vote by proxy through the internet, vote by proxy over the telephone, vote by proxy using a proxy card that you may request or that we may elect to deliver at a later time, or vote online during the Annual Meeting. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the Annual Meeting and vote online during the meeting even if you have already voted by proxy.

By Internet.   You may vote by proxy via the internet at www.proxyvote.com up until 11:59 p.m. ET on June 10, 2024, the day before the Annual Meeting, by following the instructions provided on the Notice or the proxy card. You should have your proxy card in hand when you access the website and follow the instructions to obtain your records and to create an electronic voting instruction form.

By Telephone.   If you live in the United States or Canada, you may vote by proxy by calling toll-free 1-800-690-6903 and by following the instructions provided on the proxy card. You must have the 16-digit control number that is on either the Notice or the proxy card when voting.

By Mail.   If you received a proxy card, complete and mail your proxy card in the postage prepaid envelope you receive, and return the proxy card to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717. Your proxy will be voted in accordance with your instructions. If you sign
 
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and return the enclosed proxy but do not specify how you want your shares voted, they will be voted as recommended by our Board of Directors and according to the discretion of the proxy holders named in the proxy card upon any other business that may properly be brought before the meeting and at all adjournments and postponements thereof.

By Attending the Virtual-only Annual Meeting.   You may vote your shares at www.virtualshareholdermeeting.com/MRSN2024 during the Annual Meeting. You will need the 16-digit control number that is on either the Notice or the proxy card when voting and the instructions accompanying these proxy materials.
Beneficial Owner: Shares Registered in the Name of Broker or Bank
If you are a beneficial owner of shares registered in the name of your bank, broker or other agent, you should have received a Notice containing voting instructions from that organization rather than from us. Simply follow the voting instructions in the Notice to ensure that your vote is counted. To vote online during the Annual Meeting, you must obtain a valid proxy from your bank, broker or other agent. Follow the instructions from your bank, broker or other agent included with these proxy materials, or contact that organization to request a proxy form.
We provide internet proxy voting to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your internet access, such as usage charges from internet access providers and telephone companies.
Q:
How many votes do I have?
A:
On each matter to be voted upon, you have one vote for each share of common stock you own as of the Record Date.
Q:
If I am a stockholder of record and I do not vote, or if I return a proxy card or otherwise vote without giving specific voting instructions, what happens?
A:
If you are a stockholder of record and do not vote by completing a proxy card, by telephone, through the internet or online during the Annual Meeting, your shares will not be voted.
If you return a signed and dated proxy card or otherwise vote without marking voting selections, your shares will be voted, as applicable, “FOR” the election of each of the two nominees for director, “FOR” the approval of the compensation of our named executive officers and “FOR” the ratification of the selection of our independent registered public accounting firm. If any other matter is properly presented at the Annual Meeting, your proxyholder (one of the individuals named on your proxy card) will vote your shares using his or her best judgment.
Q:
If I am a beneficial owner of shares held in street name and I do not provide my bank, broker or other agent with voting instructions, what happens?
A:
If you are a beneficial owner of shares held in street name and you do not instruct your bank, broker or other agent how to vote your shares, your bank, broker or other agent may still be able to vote your shares in its discretion. In this regard, under the rules of the New York Stock Exchange, or NYSE, brokers that are subject to NYSE rules may vote your “uninstructed” shares with respect to certain matters, but not with respect to the election of directors, executive compensation matters and certain other matters. Of the matters to be voted on at the Annual Meeting, we expect the only proposal on which your broker will have discretionary authority is Proposal 3. These NYSE rules apply to voting your shares if you are the beneficial owner of shares held in street name notwithstanding that our common stock is traded on the Nasdaq Global Select Market, or Nasdaq.
When a beneficial owner of shares held in street name does not give voting instructions to his or her bank, broker or other securities intermediary holding his or her shares as to how to vote on a particular proposal in which such bank, broker or other agent does not have discretionary authority to vote on
 
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that proposal, such bank, broker, or other agent cannot vote the shares on that particular proposal. These un-voted shares are counted as “broker non-votes.”
If you are a beneficial owner of shares held in street name, in order to ensure your shares are voted in the way you would prefer, you must provide voting instructions to your bank, broker or other agent by the deadline provided in the materials you receive from your bank, broker or other agent.
Q:
Who is paying for this proxy solicitation?
A:
We will pay for the entire cost of soliciting proxies. We have retained Georgeson LLC to assist us in the solicitation of proxies for an aggregate fee of approximately $40,000. In addition to these proxy materials, our directors and employees may also solicit proxies in person, by telephone, or by other means of communication. Directors and employees will not be paid any additional compensation for soliciting proxies. We may also reimburse brokerage firms, banks and other agents for the cost of forwarding proxy materials to beneficial owners.
Q:
What does it mean if I receive more than one Notice?
A:
If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on each of the Notices to ensure that all of your shares are voted.
Q:
Can I change my vote after submitting my proxy?
A:
Stockholder of Record: Shares Registered in Your Name
Yes. You can revoke your proxy at any time before the final vote at the Annual Meeting. If you are the record holder of your shares, you may revoke your proxy in any one of the following ways:

You may submit another properly completed proxy card with a later date before the applicable deadline.

You may grant a subsequent proxy by telephone or through the internet before the applicable deadline.

You may send a timely written notice that you are revoking your proxy to our Corporate Secretary at 840 Memorial Drive, Cambridge, Massachusetts 02139.

You may attend the virtual Annual Meeting and vote online during the meeting.
Simply attending the Annual Meeting will not, by itself, revoke your proxy.
Your most current proxy card or telephone or internet proxy is the one that is counted.
Beneficial Owner: Shares Registered in the Name of Bank or Broker
If your shares are held by your bank, broker or other agent, you must follow the instructions provided by your bank, broker or other agent to revoke your proxy.
Q:
When are stockholder proposals and director nominations due for next year’s annual meeting?
A:
Requirements for Stockholder Proposals to be Brought before an Annual Meeting
Our Second Amended and Restated Bylaws, or Bylaws, provide that, for stockholder director nominations or other proposals to be considered at an annual meeting of stockholders, the stockholder must give timely notice thereof in writing to our Secretary at c/o Mersana Therapeutics, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139. To be timely for the 2025 Annual Meeting of Stockholders, a stockholder’s notice must be delivered to or mailed to and received by our Secretary at our principal executive offices between February 11, 2025 and March 13, 2025; provided that if the date of that annual meeting of stockholders is earlier than May 12, 2025, or later than August 10, 2025, you must give the required notice not earlier than the 120th day prior to the meeting date and not
 
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later than the 90th day prior to the meeting date or, if later than the 90th day prior to such meeting date, the 10th day following the day on which public disclosure of that meeting date is first made. The required notice must meet the requirements set forth in our Bylaws (including providing the information required by Rule 14a-19 under the Securities Exchange Act of 1934, as amended, or the Exchange Act, if the stockholder intends to comply with the SEC’s universal proxy rules and to solicit proxies in support of director nominees other than the Company’s nominees).
Requirements for Stockholder Proposals to be Considered for Inclusion in Our Proxy Materials
Stockholder proposals submitted pursuant to Rule 14a-8 under the Exchange Act and intended to be presented at the 2025 annual meeting of stockholders must be received by us not later than December 27, 2024 in order to be considered for inclusion in our proxy materials for that meeting.
Q:
How many votes are needed to approve each proposal, and how are votes counted?
A:
Proposal 1 — Election of Directors
As this is an uncontested election of directors, each nominee must receive a greater number of shares voted FOR his or her election than shares voted AGAINST his or her election to be elected. Shares held in street name by banks, brokers or other agents who indicate on their proxies that they do not have authority to vote the shares on Proposal 1 will not be counted as votes FOR or AGAINST Proposal 1 and will be treated as broker non-votes. Broker non-votes will have no effect on the voting on Proposal 1. If you vote to ABSTAIN on Proposal 1, your shares will not be voted FOR or AGAINST Proposal 1 and will not be counted as votes cast or shares voting on Proposal 1. As a result, voting to ABSTAIN will have no effect on the voting on Proposal 1.
Proposal 2 — Approval, on a non-binding, advisory basis, of the compensation of our named executive officers
To approve Proposal 2, the affirmative vote of a majority of the votes cast is required. Shares held in street name by banks, brokers or other agents who indicate on their proxies that they do not have authority to vote the shares on Proposal 2 will not be counted as votes FOR or AGAINST Proposal 2 and will be treated as broker non-votes. Broker non-votes will have no effect on the voting on Proposal 2. If you vote to ABSTAIN on Proposal 2, your shares will not be voted FOR or AGAINST Proposal 2 and will not be counted as votes cast or shares voting on Proposal 2. As a result, voting to ABSTAIN will have no effect on the voting on Proposal 2.
Proposal 3 — Ratification of the selection of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2024
The approve Proposal 3, the affirmative vote of a majority of the votes cast is required. If your shares are held by your bank, broker or other agent in street name and you do not timely provide voting instructions with respect to your shares, we expect that your bank, broker or other agent will have the authority to vote your shares on Proposal 3. If you vote to ABSTAIN on Proposal 3, your shares will not be voted FOR or AGAINST Proposal 3 and will not be counted as votes cast or shares voting on Proposal 3. As a result, voting to ABSTAIN will have no effect on the voting on Proposal 3.
Q:
What is the quorum requirement?
A:
A quorum of stockholders is necessary to hold a valid meeting. A quorum will be present if stockholders holding at least a majority in voting power of the outstanding shares entitled to vote are present at the Annual Meeting in person or represented by proxy. On the Record Date, there were 122,361,236 shares outstanding and entitled to vote. Thus, the holders of 61,180,619 shares must be present in person or represented by proxy at the Annual Meeting to have a quorum.
Your shares will be counted towards the quorum only if you submit a valid proxy (or one is submitted on your behalf by your bank, broker or other nominee) or if you vote online during the Annual Meeting. Abstentions and broker non-votes will be counted towards the quorum requirement. If there is no quorum, the chair of the meeting may adjourn the Annual Meeting to another date.
 
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Q:
How can I find out the results of the voting at the Annual Meeting?
A:
Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a current report on Form 8-K that we expect to file within four business days after the date of the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the Annual Meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after the final results are known to us, file an amended Form 8-K to publish the final results.
Q:
Who should I call if I have any additional questions?
A:
If you hold your shares directly, please call Alejandra Carvajal, Secretary of the Company, at (617) 498-0020. If your shares are held in street name, please contact the telephone number provided on your voting instruction form or contact your broker or nominee holder directly.
 
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Forward-Looking Statements
Statements in this proxy statement about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute “forward-looking statements” within the meaning of The Private Securities Litigation Reform Act of 1995. The words “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including those discussed in the “Risk Factors” section of Mersana’s Annual Report on Form 10-K filed with the SEC on February 28, 2024 and the risks described in other filings that Mersana may make with the SEC. Any forward-looking statements contained in this proxy statement speak only as of the date hereof, and Mersana specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise.
 
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PROPOSAL NO. 1 — ELECTION OF DIRECTORS
Our Fifth Amended and Restated Certificate of Incorporation, as amended, or the Certificate of Incorporation, states that the Board of Directors shall consist of not fewer than three and not more than fifteen members, and the precise number of directors shall be fixed by a resolution of the Board of Directors. The size of our Board of Directors is currently fixed at eight directors. Each director holds office until his or her successor is duly elected and qualified or until his or her earlier death, resignation or removal. Any vacancy in the Board of Directors, including a vacancy that results from an increase in the number of directors, may be filled by a vote of the majority of the directors then in office.
Our Certificate of Incorporation provides that the Board of Directors is divided into three classes, with the classes as nearly equal in number as possible. Each of our directors identified below serves in the class indicated. Subject to any earlier death, resignation or removal in accordance with the terms of our Certificate of Incorporation and our Second Amended and Restated Bylaws, or the Bylaws, our Class I directors, if elected at the Annual Meeting, will serve until the 2027 annual meeting of stockholders, our Class III directors will serve until the 2026 annual meeting of stockholders, and our Class II directors will serve until the 2025 annual meeting of stockholders. Any additional directorships resulting from an increase in the number of directors will be apportioned by the Board of Directors among the three classes.
Willard H. Dere, M.D. and Martin Huber, M.D. are the Class I directors whose terms expire at the Annual Meeting. Drs. Dere and Huber have each been nominated by the Board of Directors for and agreed to stand for election to the Board of Directors to serve as a Class I director for three years and until his successor is duly elected and qualified or until his earlier death, resignation or removal.
Our Bylaws provide for a majority voting standard for the election of directors in uncontested elections, which means that to be elected, a director nominee must receive a greater number of votes FOR his or her election than votes AGAINST such election. The number of votes cast with respect to that director’s election excludes abstentions and broker non-votes with respect to that director’s election. In contested elections in which the number of director nominees exceeds the number of directors to be elected, the voting standard will be a plurality of the shares present online or by proxy and entitled to vote.
Our Nominating and Corporate Governance Committee is responsible for developing and recommending to our Board of Directors criteria for Board membership and, consistent with those criteria, recommending to the Board of Directors director candidates and nominees for the next annual meeting of stockholders. As reflected in our Corporate Governance Guidelines, it is the policy of the Board of Directors that all directors should possess the highest personal and professional ethics, integrity and values and should be committed to representing the long-term interests of our stockholders. The Nominating and Corporate Governance Committee seeks to assemble a Board of Directors that, as a whole, possesses the appropriate balance of professional and industry knowledge, financial acumen, and management experience necessary to oversee and direct Mersana’s business. The Nominating and Corporate Governance Committee and the Board of Directors also seek to attain diversity among directors of race, gender, geography, thought, viewpoints and backgrounds. To those ends, the Nominating and Corporate Governance Committee has identified and evaluated nominees in the broader context of the overall composition of the Board of Directors, with the goal of recruiting members who complement and strengthen the skills of other members through diversity. The Nominating and Corporate Governance Committee will also consider whether to nominate any person proposed by a stockholder in accordance with the provisions of our Bylaws relating to stockholder nominations as described later in this proxy statement under the heading “General Matters — Stockholder Proposals and Nominations.”
The Board of Directors is currently comprised of eight members. Below is a list of the names, ages as of April 26, 2024 and classification of the individuals who currently serve as our directors.
Name
Age
Position
Willard H. Dere, M.D
70
Director (Class I)
Martin Huber, M.D.
64
Director (Class I); President and Chief Executive Officer
Allene M. Diaz
59
Director (Class II)
Andrew A. F. Hack, M.D., Ph.D.
50
Director (Class II)
 
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Name
Age
Position
Kristen M. Hege, M.D.
60
Director (Class II)
Lawrence M. Alleva
74
Director (Class III)
David Mott
58
Chair of the Board of Directors (Class III)
Anna Protopapas
59
Director (Class III)
Certain individual qualifications and skills of our directors that contribute to our Board of Directors’ effectiveness as a whole are described in the following paragraphs.
Nominees for Election as Class I Directors
Biographical information, including principal occupation, business experience and public company board experience during the last five years, for our nominees for election as Class I directors at the Annual Meeting is set forth below.
Willard H. Dere, M.D., has served as a member of our Board of Directors since March 2018. Dr. Dere has served as Chief Medical Officer of Angitia Biopharmaceuticals, a biotechnology company, since June 2023, and he has also served as Chief Advisor to the CEO since July 2022. In June 2022, Dr. Dere retired from the Utah Health Services Center, where he had served as Professor of Internal Medicine, B. Lue and Hope S. Bettilyon Presidential Endowed Chair in Internal Medicine for Diabetes Research, Executive Director of Personalized Health and Co-Director of the Clinical and Translational Science Institute since June 2014 and as Associate Vice President for Research since July 2019. Dr. Dere has served on the boards of directors of BioMarin Pharmaceutical Inc., a biopharmaceutical company, since July 2016; of Seres Therapeutics, Inc., a biotechnology company, since July 2017; and of Metagenomi, Inc., a genetic medicines company, since August 2021. He previously served as a director of Radius Health, Inc., a biopharmaceutical company, from November 2014 until its acquisition in August 2022. Dr. Dere received a B.A. and an M.D. from the University of California, Davis. We believe that Dr. Dere’s research, clinical and regulatory biopharmaceutical leadership experience qualify him to serve as a director.
Martin Huber, M.D., has served as our President and Chief Executive Officer since September 2023 and as a member of our Board of Directors since April 2020. Dr. Huber served as President and Head of R&D of Xilio Therapeutics, Inc., or Xilio, a biotechnology company, from June 2022 to September 2023. He served as Xilio’s President of R&D from August 2021 to June 2022 and as Chief Medical Officer from April 2020 to June 2022. Prior to that, he served as Senior Vice President, Chief Medical Officer at TESARO, Inc., or TESARO, an oncology-focused company, from September 2015 to January 2019, and after TESARO’s acquisition by GlaxoSmithKline plc, or GSK, a global healthcare company, he served as Senior Vice President, Clinical, from January 2019 to April 2020. Dr. Huber has served on the board of directors of Syndax Pharmaceuticals, Inc., a biotechnology company, since September 2021. Dr. Huber received a B.S. in biology from Texas Lutheran College and an M.D. from Baylor College of Medicine. We believe that Dr. Huber’s medical, clinical and regulatory experience, as well as his insight into our business as President and Chief Executive Officer of our company, qualify him to serve as a director.
Recommendation of the Board of Directors
OUR BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS
VOTE “FOR” EACH OF THE NOMINEES FOR CLASS I DIRECTOR.
Any properly submitted proxy will be voted in favor of the nominees unless a contrary specification is made in the proxy. The nominees have consented to serve as directors if elected. However, if any nominee is unable to serve or for good cause will not serve as a director, the persons named in the proxy intend to vote in their discretion for one or more substitutes who will be designated by our Board of Directors.
Directors Continuing in Office
Biographical information, including principal occupation, business experience and public company board experience during the last five years, for our current directors continuing in office is set forth below.
 
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Class II Directors (Term Expires at 2025 Annual Meeting)
Allene M. Diaz has served as a member of our Board of Directors since March 2021. Ms. Diaz has led AMD Consulting, a new product strategy and portfolio management consulting practice, since August 2020 and serves as a senior advisor to Bain Capital Life Sciences, or Bain Capital, a private equity fund that invests in biopharmaceutical, specialty pharmaceutical, medical device, diagnostics and life science technology companies globally. She held the position of Senior Vice President of R&D Portfolio Management at GSK from September 2019 to June 2020. From May 2015 to September 2019, she served as the Senior Vice President of Global Commercial Development and Program Strategy and as a member of the Executive Leadership Team at TESARO. Ms. Diaz has served on the board of directors of Ionis Pharmaceuticals, Inc., a biotechnology company, since June 2021. She previously served as a director of BCLS Acquisition Corp., a special purpose acquisition company, from October 2020 until November 2022; of Allena Pharmaceuticals, Inc., a biopharmaceutical company, from April 2019 until September 2022; and of Erytech Pharma SA, a biopharmaceutical company, from September 2016 to September 2019. Ms. Diaz received a B.S. in psychology from Florida State University. We believe that Ms. Diaz’s experience in the commercial development of and program strategy for oncology assets and her executive leadership and business experience in the biotechnology sector qualifies her to serve as a member of our Board of Directors.
Andrew A. F. Hack, M.D., Ph.D., has served as a member of our Board of Directors since January 2017. Dr. Hack has served as a Partner of Bain Capital since March 2019. Before joining Bain Capital, Dr. Hack was the Chief Financial Officer of Editas Medicine, Inc., a biotechnology company, from July 2015 through March 2019. Dr. Hack has served on the board of directors of Nuvalent, Inc., a biotechnology company, or Nuvalent, since April 2021. He previously served as a director of Dynavax Technologies Corp., a biopharmaceutical company, from August 2019 to August 2023; of BCLS Acquisition Corp. from October 2020 until November 2022; of Allena Pharmaceuticals, Inc., a biopharmaceutical company, from June 2018 to June 2021; and of Atea Pharmaceuticals, Inc., a biopharmaceutical company, from May 2020 to June 2021. Dr. Hack received an A.B. in biology with special honors, an M.D. and a Ph.D. in molecular genetics and cell biology from the University of Chicago. We believe that Dr. Hack’s financial and medical background, as well as his experience in the biotechnology sector, qualify him to serve as a member of our Board of Directors.
Kristen M. Hege, M.D., has served as a member of our Board of Directors since August 2016. Dr. Hege retired as Senior Vice President, Early Clinical Development, Hematology/Oncology & Cell Therapy at Bristol Myers Squibb Company, or BMS, a global biopharmaceutical company, a position she held from November 2019, when BMS acquired Celgene Corporation, a pharmaceutical company, or Celgene, until March 2023. She joined Celgene in 2010 as Vice President, Translational Development. Dr. Hege also held an active faculty position at the University of California, San Francisco Medical Center from 1996 to 2023, most recently as Clinical Professor of Medicine, Hematology/Oncology, serving in that role as a volunteer since 2008. Dr. Hege has served on the board of directors of Adaptimmune Therapeutics plc, a biopharmaceutical company, or Adaptimmune, since November 2023. She also previously served as a director of Graphite Bio, Inc., a biotechnology company, from April 2021 until its reverse merger with LENZ Therapeutics, Inc. in March 2024, and of Arcus Biosciences, Inc., a biopharmaceutical company, from October 2018 to November 2019. Dr. Hege received a B.A. in biochemistry summa cum laude from Dartmouth College and an M.D. from University of California, San Francisco. We believe that Dr. Hege’s medical background and experience in the biotechnology industry qualify her to serve as a director.
Class III Directors (Term Expires at 2026 Annual Meeting)
Lawrence M. Alleva has served as a member of our Board of Directors since September 2017. Prior to his retirement in June 2010, Mr. Alleva was employed by PricewaterhouseCoopers LLP, or PwC, a professional services firm, for 39 years, including 28 years as a partner. Mr. Alleva has served on the boards of directors of Bright Horizons Family Solutions Inc., an education and childcare company, since 2012; of Galera Therapeutics, Inc., an oncology radiation company, since June 2019; and of Adaptimmune since March 2015. Mr. Alleva is a Certified Public Accountant (inactive). Mr. Alleva received a B.S. in accounting from Ithaca College and attended the Columbia University Executive MBA (non-degree) Program. We believe that Mr. Alleva’s extensive experience and expertise working with public companies on corporate finance and
 
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accounting matters as a Certified Public Accountant, his experience serving on other corporate boards and his experience in a senior leadership role at PwC provide him with the qualifications and skills to serve as a director.
David Mott has served as Chair of our Board of Directors since July 2012. Mr. Mott is a private investor through Mott Family Capital. From September 2008 until his retirement in February 2020, Mr. Mott served as a general partner of New Enterprise Associates, an investment firm focused on venture capital and growth equity investments, where he led the healthcare investing practice. Mr. Mott has served on the boards of directors of Adaptimmune since February 2015 and as chair thereof since January 2017; of Ardelyx, Inc., a biopharmaceutical company, since March 2009 and as chair thereof since March 2014; and of Novavax, Inc., a biotechnology company, since June 2020. He previously served as a director of Imara, Inc., a biotechnology company, from January 2016 and as chair of the board of directors from April 2016 until the reverse merger between Imara, Inc. and Enliven Therapeutics, Inc. in February 2023; of Epizyme, Inc. from December 2009 and as chair of the board of directors from April 2016 until its acquisition by Ipsen Pharma SAS in August 2022; and as a director of Nightstar Therapeutics plc from August 2015 until its acquisition by Biogen Inc. in June 2019. Mr. Mott received a B.A. from Dartmouth College. We believe that Mr. Mott’s leadership experience in the biotechnology industry, his experience investing in life sciences companies and his financial experience provide him with the qualifications and skills to serve as director.
Anna Protopapas has served as a member of our Board of Directors since March 2015. She previously served as our President and Chief Executive Officer from March 2015 until her retirement in September 2023. Ms. Protopapas has served as chair of the board of directors of Nuvalent since March 2022. She previously served as a director of Dicerna Pharmaceuticals, Inc., a biotechnology company, from January 2019 until June 2021. Ms. Protopapas received a B.S. in science and engineering from Princeton University, an M.S. in chemical engineering practice from the Massachusetts Institute of Technology and an M.B.A. from Stanford Graduate School of Business. We believe that Ms. Protopapas is qualified to serve as a member of our Board of Directors based on her experience in the pharmaceutical industry and her insight into our business based on her service as our former President and Chief Executive Officer, including her business development expertise honed during such experiences.
 
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INFORMATION REGARDING THE BOARD OF DIRECTORS AND CORPORATE GOVERNANCE
Director Independence
Under Nasdaq Rule 5605, a majority of a listed company’s board of directors must generally be comprised of independent directors. In addition, Nasdaq rules require that, subject to specified exceptions, each member of a listed company’s audit committee, compensation committee and nominating and corporate governance committee be independent and, in the case of the audit committee and compensation committee, satisfy additional independence criteria set forth in Rules 10A-3 and 10C-1, respectively, under the Securities Exchange Act of 1934, as amended, or the Exchange Act.
Based upon information requested from and provided by each director concerning his or her background, employment and affiliations, including family relationships, in March 2024, the Board of Directors determined that each director other than Dr. Huber, who currently serves as our President and Chief Executive Officer, and Ms. Protopapas, who served as our President and Chief Executive Officer until September 10, 2023, representing six of our eight directors, or 75%, is “independent” as that term is defined under Nasdaq Rule 5605(a)(2). The Board of Directors also determined that each of the current members of our Audit Committee, Compensation Committee and Nominating and Corporate Governance Committee satisfies the independence standards for such committee established by Rules 10A-3 and 10C-1 under the Exchange Act and the Nasdaq rules, as applicable. In making such determination, the Board of Directors considered the relationships that each such non-employee director has with Mersana and all other facts and circumstances deemed relevant in determining their independence.
There are no family relationships among any of our directors or executive officers.
Board Demographic Mix; Skills and Expertise
Our eight directors have provided the following responses on their self-identification of gender identity, demographic background, and self-identification as LGBTQ+:
Board Diversity Matrix (as of April 26, 2024)
Total Number of Directors
8
Female
Male
Non-Binary
Did not
Disclose
Gender
Part I: Gender Identity
Directors
3
5
Part II: Demographic Background
African American or Black
Alaskan Native or Native American
Asian
1
Hispanic or Latinx
1
Native Hawaiian or Pacific Islander
White
2
4
Two or More Races or Ethnicities
LGBTQ+
1
Did not Disclose Demographic Background
 
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In addition, our Board of Directors assessed the skills that each member contributes to address the specific needs of the Company, as reflected below:
[MISSING IMAGE: bc_directors-4c.jpg]
Board Meetings and Attendance
The Board of Directors held 13 meetings during the year ended December 31, 2023. Each of the directors other than Dr. Hege attended at least seventy-five percent (75%) of the aggregate meetings of the Board of Directors and the committees of the Board of Directors on which he or she served during the year ended December 31, 2023 (in each case, which were held during the period for which he or she was a director and/or a member of the applicable committee). Dr. Hege attended 72% of such meetings.
The non-employee directors regularly meet in executive session during regularly scheduled Board of Directors meetings, and the non-employee directors who serve on each of our standing committees regularly meet in executive session without management present during regularly scheduled meetings of such committees.
It is a policy of the Board of Directors that its members make every effort to attend our annual stockholder meetings. All of our directors attended the 2023 annual meeting of stockholders.
Board of Directors Leadership Structure
Our current Board leadership structure separates the positions of Chief Executive Officer and Chair of the Board of Directors, although we do not have a corporate policy requiring that structure. The Board of Directors believes that this separation is appropriate for Mersana at this time because it allows for a division of responsibilities and the sharing of ideas between individuals having different perspectives. Our Chief Executive Officer, who is also a member of our Board of Directors, is primarily responsible for our operations and strategic direction, while our Board Chair, who is an independent member of the Board of Directors, is primarily focused on matters pertaining to corporate governance, including management oversight and
 
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strategic guidance. The Board of Directors believes that this is the most appropriate structure at this time but, consistent with our Corporate Governance Guidelines, will make future determinations regarding whether or not to separate the roles of Chair and Chief Executive Officer based on then-current circumstances.
The Board of Directors’ Role in Risk Oversight
The Board of Directors plays an important role in risk oversight at Mersana through direct decision-making authority with respect to significant matters, as well as through the oversight of management by the Board of Directors and its committees. In particular, the Board of Directors administers its risk oversight function through (1) the review and discussion of regular periodic reports by the Board of Directors and its committees on topics relating to the risks that Mersana faces, including those identified by management in its periodic enterprise risk management assessments, (2) the required approval by the Board of Directors (or a committee of the Board of Directors to which the Board of Directors has delegated such responsibility) of significant transactions and other decisions, (3) the direct oversight of specific areas of our business by the Audit, Compensation and Nominating and Corporate Governance Committees and (4) regular periodic reports from the auditors and other outside consultants, including our compensation consultant, regarding various areas of potential risk, including, among others, those relating to our internal control over financial reporting and our compensation policies and practices. The Board of Directors also relies on management to bring significant matters impacting Mersana to its attention. Members of our senior management team attend meetings of our Board of Directors and its committees and are available to address any questions or concerns raised by our directors related to risk management and any other matters.
Pursuant to the Audit Committee’s charter, the Audit Committee is responsible for reviewing and discussing with management and our independent registered public accounting firm our system of internal controls, its financial and critical accounting practices and its policies relating to risk assessment and management. As part of this process, the Audit Committee discusses our major financial risk exposures and steps that management has taken to monitor and control such exposures. In addition, the Audit Committee has established procedures for the receipt, retention and treatment of complaints we may receive regarding accounting, internal accounting controls or auditing matters, and the confidential, anonymous submissions by employees of concerns regarding questionable accounting or accounting matters. The Audit Committee also oversees cybersecurity matters, including with respect to the integrity of our information technology systems, processes and data, and the Audit Committee periodically reviews and assesses with management the adequacy of controls and security thereof, along with incident response and contingency plans in the event of a breakdown or security breach affecting our information technology systems. Furthermore, the Audit Committee meets privately with representatives from our independent registered public accounting firm as part of its oversight of our risk management.
Pursuant to the Compensation Committee’s charter, the Compensation Committee oversees risk management activities relating to our compensation policies and practices and to succession planning for the members of our senior management. Pursuant to the Nominating and Corporate Governance Committee’s charter, the Nominating and Corporate Governance Committee oversees risk management activities relating to the composition of our Board of Directors and succession planning for our Board of Directors.
The Board of Directors believes that any leadership structure that it adopts must allow it to effectively oversee the management of the risks relating to Mersana’s operations. The Board of Directors acknowledges that there are different leadership structures that could allow it to effectively oversee the management of the risks relating to Mersana’s operations and believes its current leadership structure enables it to effectively provide oversight with respect to such risks.
Code of Business Conduct and Ethics and Corporate Governance Guidelines
We have adopted a Code of Business Conduct and Ethics that applies to all of our employees, officers and directors, including those officers responsible for financial reporting. A copy of our Code of Business Conduct and Ethics may be accessed free of charge by visiting our website at www.mersana.com and going to the “Governance” tab under the “Investors & Media” section, or by requesting a copy in writing from our Secretary at our Cambridge, Massachusetts office. We intend to post on our website any amendment to, or waiver under, a provision of the Code of Business Conduct and Ethics that applies to our directors and certain of our executive officers within four business days following the date of such amendment or waiver.
 
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A copy of the Corporate Governance Guidelines may also be accessed free of charge by visiting our website at www.mersana.com and going to the “Governance” tab under the “Investors & Media” section, or by requesting a copy in writing from our Secretary at our Cambridge, Massachusetts office.
Board Committees
The Board of Directors has standing Audit, Compensation and Nominating and Corporate Governance Committees, each of which is comprised solely of independent directors and is described more fully below. Each committee operates pursuant to a written charter, and each reviews and assesses the adequacy of its charter periodically and submits its charter to the Board of Directors for approval. The charter for each committee is available on our website (www.mersana.com) under the “Governance” tab under the “Investors & Media” section. Additionally, each standing committee periodically performs, or participates in, under the oversight of the Nominating and Corporate Governance Committee, an evaluation of such committee against the requirements of the committee’s charter, the results of which are presented to the Board of Directors.
The following table describes which directors serve on each of the Board of Directors’ committees as of the date of this proxy statement.
Name
Audit
Committee
Compensation
Committee
Nominating
and
Corporate
Governance
Committee
Lawrence M. Alleva
Chair
X
Willard H. Dere, M.D.
X
Chair
Allene M. Diaz
X
Andrew A.F. Hack, M.D., Ph.D.
X
Kristen M. Hege, M.D.(2)
X(1)
X(2)
David Mott
Chair
(1)
Dr. Hege served as a member of Compensation Committee from January 1, 2023 until March 31, 2023 and resumed serving as a member of the Compensation Committee on October 1, 2023.
(2)
Dr. Hege began serving as a member of our Nominating and Corporate Governance Committee on October 1, 2023.
Audit Committee
Our Audit Committee is composed of Mr. Alleva and Drs. Dere and Hack, with Mr. Alleva serving as Chair of the committee. The Board of Directors has determined that each member of the Audit Committee meets the independence requirements of Rule 10A-3 under the Exchange Act and the applicable listing standards of Nasdaq. The Board of Directors has determined that Mr. Alleva and Dr. Hack are “audit committee financial experts” within the meaning of SEC regulations and applicable listing standards of Nasdaq.
The Audit Committee’s responsibilities include:

evaluating, determining the selection of, and, if necessary, determining the replacement or rotation of the independent auditor, the lead audit partner, and any other active audit engagement team;

pre-approving or approving all auditing services and all permitted non-audit services by the independent auditor and pre-approving the related fees;

ensuring the receipt of, reviewing, evaluating, and discussing formal written reports from the independent auditor regarding the auditor’s independence, engaging in a dialogue with the independent auditor with respect to any disclosed relationships or services that may impact its objectivity and independence, and taking, or recommending that the Board takes, appropriate action to oversee the independence of the independent auditor;

establishing hiring policies for employees or former employees of the independent auditors;
 
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(i) obtaining and reviewing a report from the independent auditor describing the firm’s internal quality-control procedures and any material issues raised by the most recent quality control review, or peer review, of the firm, or by any inquiry or investigation by governmental or professional authorities, within the preceding five years, with respect to one or more independent audits carried out by the firm, and any steps taken to deal with any such issues, and (ii) assessing the auditor’s independence and all relationships between the independent auditor and the Company;

obtaining assurance from the independent auditors that, to the extent applicable, Section 10A(b) of the Exchange Act has not been implicated;

reviewing with the independent auditor the overall scope and plans for audits and reviewing with the independent auditor any noteworthy audit problems or difficulties;

reviewing and discussing with management and the independent auditor the scope of the Company’s system of internal controls, its financial and critical accounting practices, and its policies relating to risk assessment and management;

reviewing disclosures about any significant deficiencies or material weaknesses in the design or operation of the Company’s system of internal controls and any fraud involving management or employees playing a significant role in the Company’s system of internal controls;

reviewing any special steps or remedial measures adopted in light of material control weaknesses or significant deficiencies, if any;

reviewing, to the extent applicable, the Company’s internal controls report and the independent auditor’s internal controls report prior to the filing of any reports;

reviewing with management the Company’s procedures and practices designed to provide reasonable assurance that (i) the Company’s books, records, accounts, and internal accounting controls are established and maintained in compliance with the Foreign Corrupt Practices Act of 1977 and similar laws and regulations to which the Company is subject, and (ii) there are adequate company-level controls in place to prevent or detect (A) any improper or illegal disbursement of corporate funds or property of value or (B) the making of any arrangement on behalf of the Company which may provide for or result in the improper or illegal disbursement of funds or property of value, in order that the Company be in compliance with such laws and regulations;

receiving and reviewing reports of the independent auditor discussing (i) all critical accounting policies and practices used in the preparation of the Company’s financial statements, (ii) all alternative treatments of financial information within generally accepted accounting principles, or GAAP, that have been discussed with management, the ramifications of the use of such alternatives and the treatment preferred by the independent auditor and (iii) other material written communications between the independent auditor and management, such as any management letter or schedule of unadjusted differences;

discussing with management and the independent auditor changes in the Company’s critical accounting principles and the effects of alternative GAAP methods, off-balance sheet structures, and regulatory and accounting initiatives;

reviewing and discussing with management and the independent auditor the annual and quarterly financial statements and management’s discussion and analysis of financial condition and results of operations of the Company prior to the filing of the Company’s Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q; discussing results of the annual audit and quarterly reviews and any other matters required to be communicated to the committee by the independent auditor under generally accepted auditing standards, including Auditing Standard No. 1301; discussing with management and the independent auditor their judgment about the quality of accounting principles, the reasonableness of significant judgements and the clarity of disclosure in the financial statements, including the Company’s disclosures of critical accounting policies and other disclosures in “Management’s Discussion and Analysis of Financial Condition of Results of Operations” in its Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q;

reviewing, or establishing standards for the type of information and the type of presentation of such information to be included in, earnings press releases;
 
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discussing with management and the independent auditors any correspondence with regulators or governmental agencies and any published reports, if any, that raise material issues regarding, or call into question the integrity of, the Company’s financial statements or accounting policies;

reviewing material pending legal proceedings and other contingent liabilities involving the Company;

establishing procedures for the receipt, retention, and treatment of complaints received by the Company regarding accounting, internal accounting controls or auditing matters, and the confidential, anonymous submissions by employees of concerns regarding questionable accounting or auditing matters;

assisting the Board of Directors in its oversight of risk;

overseeing the integrity of the Company’s information technology systems, processes, and data, and shall periodically, at its discretion, (i) review and assess with management the adequacy of controls and security for the Company’s information technology systems, process and data, and (ii) the Company’s contingency plans in the event of a breakdown or security breach affecting the Company’s information technology systems; and

reviewing and approving all “related party transactions” in accordance with Company policy.
During the year ended December 31, 2023, the Audit Committee met seven times. The members of the Audit Committee regularly meet in executive session with representatives of Ernst & Young LLP without management present.
Compensation Committee
Our Compensation Committee is currently composed of Mr. Mott, Ms. Diaz, and Dr. Hege, with Mr. Mott serving as Chair of the committee. Dr. Hege served as a member of the Compensation Committee from January 1, 2023 until March 31, 2023 and resumed serving on the Compensation Committee on October 1, 2023. Dr. Huber served as a member of our Compensation Committee from April 1, 2023 until September 10, 2023. The Board of Directors has determined that each current member of our Compensation Committee, as well as Dr. Huber at the time he served on the Compensation Committee, is (or was, in the case of Dr. Huber) “independent” as defined under the applicable listing standards of Nasdaq and meets or met the independence criteria set forth in Rule 10C-1.
Our Compensation Committee’s responsibilities include:

reviewing and establishing the Company’s overall management compensation benefits philosophy and policies;

reviewing and approving corporate goals and objectives relevant to the compensation of the Company’s Chief Executive Officer, or the CEO, evaluating the performance of the CEO in light of those goals and objectives, and either as a committee or together with the other independent directors (as directed by the Board), recommending to the Board for approval the compensation level for the CEO based on such evaluation, with the deliberations and voting on the CEO’s compensation to be conducted without the CEO present;

reviewing and approving corporate goals and objectives relevant to the compensation of the officers of the Company who report directly to the CEO and all officers (other than the CEO) who are “insiders” subject to Section 16 of the Exchange Act, or the Senior Officers, evaluating the performance of the Senior Officers in light of those goals and objectives, and, either as a committee or together with the other independent directors (as directed by the Board), determining and approving, or recommending to the Board for approval, the compensation levels for the Senior Officers;

making recommendations to the Board about the compensation of the members of the Board;

reviewing and administering the Company’s equity-based compensation plans, management incentive compensation plans and deferred compensation plans and making recommendations to the Board about amendments to such plans and the adoption of any new compensation plans;
 
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recommending to the Board any ownership guidelines for the CEO, the Senior Officers, other executives and non-employee directors, and periodically assessing these guidelines and recommending revisions as appropriate;

approving, or recommending for approval by the Board, the implementation or revision of any compensation recovery or “clawback” policies of the Company, and overseeing the administration of such policies;

producing, if required, a compensation committee report on executive compensation for inclusion in the Company’s Annual Report on Form 10-K and its annual proxy statement;

reviewing and approving all employment contracts and other compensatory, severance, and change-in-control arrangements for the CEO and the Senior Officers;

establishing and reviewing policies and procedures with respect to perquisites;

reviewing the Company’s incentive compensation arrangements to determine whether they encourage excessive risk-taking; reviewing and discussing the relationship between risk management policies and practices and compensation, and evaluating compensation policies and practices that could mitigate any such risk; and

overseeing the maintenance and presentation to the Board of Directors of management’s plans for succession to senior management positions in the Company based on guidelines developed and recommended by our Compensation Committee to the Board.
Our Compensation Committee may delegate any of the responsibilities of the full committee described above to subcommittees and may delegate the determination of compensation under approved compensation programs to the CEO and/or Senior Officers, except that compensation actions affecting the CEO or Senior Officers may not be so delegated.
Additional information concerning the role of our Compensation Committee, and its processes and procedures, is set forth elsewhere in this proxy statement under “Compensation Discussion and Analysis — Executive Compensation Process.” Please also see the report of our Compensation Committee set forth elsewhere in this proxy statement.
During the year ended December 31, 2023, our Compensation Committee met ten times.
Nominating and Corporate Governance Committee
Our Nominating and Corporate Governance Committee is composed of Mr. Alleva and Drs. Dere and Hege, with Dr. Dere serving as Chair of the committee. Dr. Hege began serving as a member of our Nominating and Corporate Governance Committee on October 1, 2023. Dr. Huber served as a member of our Nominating and Corporate Governance Committee from January 1, 2023 until September 10, 2023. The Board of Directors has determined that each current member of our Nominating and Corporate Governance Committee, as well as Dr. Huber at the time he served on the Nominating and Corporate Governance Committee, is (or was, in the case of Dr. Huber) “independent” as defined under the applicable listing standards of Nasdaq.
The Nominating and Corporate Governance Committee’s responsibilities include:

identifying individuals qualified to become members of our Board of Directors, consistent with criteria approved by the Board, receiving nominations for such qualified individuals and reviewing recommendations put forward by the CEO, and recommending to the Board the director nominees for the next annual meeting of stockholders, taking into account each candidate’s ability, judgment and experience and the overall diversity and composition of the Board;

recommending to our Board of Directors the classes of the Board on which nominees should serve;

establishing a policy under which stockholders of the Company may recommend a candidate for consideration for nomination as a director;

if a vacancy on the Board of Directors or any Board committee occurs, identifying and recommending to the Board qualified candidates to fill such vacancy;
 
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developing and recommending to the Board of Directors a set of corporate governance guidelines applicable to the Company that address, at a minimum, the following subjects: (i) director qualification standards, (ii) director responsibilities, (iii) director access to management and, as necessary and appropriate, independent advisors, (iv) director compensation, (v) director orientation and continuing education, and (vi) annual performance evaluations of the Board of Directors;

reviewing the corporate governance guidelines and recommending changes as necessary;

articulating to each director what service on the Board of Directors entails;

reviewing the Company’s practices and policies with respect to directors, including retirement policies, the size of the Board, service of non-employee directors, the meeting frequency of the Board of Directors and the structure of Board meetings;

recommending to the Board of Directors or to the appropriate committee thereof processes for annual evaluations of the performance of the Board of Directors and the appropriate committees thereof and overseeing such evaluation processes;

reviewing the functions, duties, and composition of the committees of the Board of Directors;

reviewing Company policies with respect to significant issues of corporate public responsibility;

considering and reporting to the Board of Directors any questions of possible conflicts of interest of members of the Board of Directors;

reviewing and overseeing the Company’s strategies regarding the management of environmental, social and governance, or ESG, matters, including related risks and opportunities, and periodically reviewing the Company’s public disclosures with respect to such matters, including in the review of these Company strategies a focus on the Company’s culture and enterprise efforts relating to fostering and maintaining a diverse, inclusive and equitable environment;

overseeing the systems and processes established by the Company to ensure compliance with the Company’s Code of Business Conduct and Ethics;

providing for new director orientation and continuing education for existing directors on a periodic basis; and

overseeing plans for director succession.
During the year ended December 31, 2023, the Nominating and Corporate Governance Committee met four times.
Compensation Committee Interlocks and Insider Participation
None of the members of our Compensation Committee has at any time during the prior three years been one of our officers or employees. None of our executive officers currently serves, or in the past fiscal year has served, as a member of the board of directors or compensation committee of any entity that has one or more executive officers serving on our Board of Directors or Compensation Committee.
 
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ENVIRONMENTAL, SOCIAL AND GOVERNANCE (“ESG”) PRACTICES
At Mersana, we all share a singular vision: To create a world where all patients triumph over cancer. We know that the actions of each and every one of us matter and that our team’s success depends on our ability to work together. We are also committed to making a positive impact as it relates to the environment and the communities in which we live and work. We believe that we have a duty to our patients and other stakeholders to be good corporate citizens, and we are committed to embracing diversity while operating our business in an environmentally-friendly manner and with high integrity and transparency.
In line with this commitment, in 2022 we formed an internal ESG working group to identify potential areas in which we can improve, make recommendations to the executive team, implement new practices and track our execution across our ESG initiatives. This team is composed of a cross-functional group of employees that includes members of senior management. Additionally, pursuant to its charter, our Nominating and Corporate Governance Committee is responsible for reviewing and overseeing Mersana’s strategies regarding the management of ESG matters, including related risks and opportunities, with a focus on our culture and enterprise efforts relating to fostering and maintaining a diverse, inclusive and equitable environment.
Environmental
We are committed to implementing eco-friendly and sustainability programs to minimize our environmental footprint. Although our current physical footprint is limited to approximately 45,000 square feet of leased office and laboratory space at our Cambridge, Massachusetts headquarters, we believe it is our duty to be mindful of the impact we are having on our environment. Our environmentally-conscious products and programs include the use or provision of:

LED lighting;

public transportation reimbursement;

composting;

battery recycling receptacles;

dedicated recycling streams for pipette tip boxes;

reusable kitchen products;

recycled paper products; and

water machines that helped eliminate the use of more than 25,000 plastic bottles in 2023 alone.
In 2017, a group of Mersana employees established the “Green Team,” a cross-functional group of employees dedicated to limiting the impact that our daily office routines have on the planet. Since its inception, the Green Team has spearheaded initiatives to reduce office waste, clean local water sources, save energy and promote environmental awareness and sustainability in the office. In an effort to help beautify the outdoor space adjacent to our headquarters, Mersana’s Green Team organizes river cleanups to collect debris along the Charles River.
Social
Human Capital Management
As of December 31, 2023, we had 123 full-time employees, including 83 with M.D., Ph.D. or other advanced degrees. We believe that our future success largely depends upon our continued ability to attract and retain highly skilled employees. Our human capital objectives include, as applicable, identifying, recruiting, retaining, incentivizing and integrating our existing and newly-hired employees, and focusing on employee well-being and workplace safety. We provide our employees with competitive salaries and bonuses, opportunity for equity ownership, development programs that enable continued learning and growth, and a robust employment package that promotes wellness across all aspects of their lives, including healthcare, retirement planning and paid time off.
 
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Diversity, Equity, Inclusion and Belonging
As we advance our pipeline, we are also heavily focused on advancing our people. We believe that people who learn, grow and thrive together are better equipped to elevate our science. We believe that promoting diversity, equity, inclusion and belonging and sustainability is key to fostering our collaborative work environment in which employees are motivated by the common goal of discovering, developing and delivering potential new therapies for patients with cancer.
We strive to build a workforce representative of the communities in which we live and work and the patients we serve and to nurture an inclusive culture where all voices are welcomed, heard and respected. Our organization is composed of individuals with a broad range of backgrounds and experiences, providing us with a spectrum of perspectives that we can draw upon as Mersana continues to evolve. Of our executive team, which includes the Senior Officers other than our Vice President, Chief Accounting Officer, who serves as our principal accounting officer, 14% self-identified as female and 43% self-identified as belonging to at least one racially or ethnically diverse group. Of our employees as of December 31, 2023 who chose to indicate their gender and ethnic identities, 56% self-identified as female and 39% self-identified as belonging to at least one racially or ethnically diverse group.
Corporate Citizenship
We believe it is our responsibility to be good corporate neighbors. We encourage employees to take an active role in caring for the surrounding communities in which we live and work, and we regularly sponsor events, lead fundraising drives and promote opportunities to get involved with local and national charitable organizations.
Governance
Ethics & Accountability
Our Board of Directors and our Senior Officers are committed to setting a tone of integrity from the top. Mersana’s Code of Business Conduct and Ethics requires all Mersana directors, officers and employees to adhere to the highest standards of honest and ethical conduct. Our Code of Business Conduct and Ethics covers a variety of topics, including (i) complying with laws, rules, regulations and ethics, (ii) bribery and corruption, and (iii) conflicts of interest. In addition to our Code of Business Conduct and Ethics, our other policies are clearly defined and include guidance on topics including, but not limited to, corporate governance and avoiding insider trading. We provide all of our employees with initial training and reference materials and periodic refresh materials to reinforce this commitment to integrity and ethics in our business.
Our Board of Directors, along with the Audit, Compensation and Nomination and Corporate Governance Committees, conducts an annual governance review, which includes review, benchmarking and revision of our significant corporate policies discussed above. Our Compensation Committee also conducts an annual review of our compensation practices. Additionally, each standing committee of the Board of Directors periodically performs, or participates in, under the oversight of the Nominating and Corporate Governance Committee, an evaluation of such committee against the requirements of the committee’s charter, the results of which are presented to the Board of Directors.
 
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NON-EMPLOYEE DIRECTOR COMPENSATION
We maintain an amended and restated non-employee director compensation policy, or the NED Compensation Policy, which provides that each of our non-employee directors (that being, each of our directors other than Ms. Protopapas until September 10, 2023 and each of our directors other than Dr. Huber from and after September 11, 2023) will receive the following compensation for service on our Board:

an annual cash retainer of $40,000 ($70,000 for the Chair of our Board of Directors);

an additional annual cash retainer of $5,000 for each non-employee director who is a member of our Compensation Committee ($10,000 for the Chair of our Compensation Committee);

an additional annual cash retainer of $4,000 for each non-employee director who is a member of our Nominating and Corporate Governance Committee ($8,000 for the Chair of our Nominating and Corporate Governance Committee);

an additional annual cash retainer of $7,500 for each non-employee director who is a member of our Audit Committee ($15,000 for the Chair of our Audit Committee);

for any non-employee director who is first elected or appointed to our Board of Directors, an initial equity award; and

on an annual basis, for each non-employee director (other than a director who is first elected to our Board of Directors during the calendar year of such annual meeting of stockholders (including, for the avoidance of doubt, at the time of the annual meeting of stockholders)), an annual equity award.
Each non-employee director is also entitled to reimbursement for reasonable travel and other expenses incurred in connection with attending meetings of the Board of Directors and any committee on which he or she serves.
Any outstanding initial equity awards and annual equity awards granted to our non-employee directors automatically accelerate and become fully vested and exercisable upon the non-employee director’s death or termination of service due to disability or upon a change in control.
2023 Non-Employee Director Compensation
For the year ended December 31, 2023, the initial equity awards for which any new non-employee director would have been eligible would have been (a) a stock option to purchase the lesser of (i) 45,000 shares of our common stock or (ii) a number of shares of our common stock having a grant date fair value equal to $250,000, with the number of shares of common stock determined in accordance with Accounting Standards Codification, or ASC, Topic 718, rounded down to the nearest whole share, and (b) restricted stock units, or RSUs, representing the lesser of (i) 45,000 shares of common stock or (ii) a number of shares of common stock equal to (a) $250,000 divided by (b) the closing sales price per share of our common stock on Nasdaq on the date of the non-employee director’s initial election or appointment to the Board of Directors (or, if such date is not a market trading day, on the first market trading day thereafter), rounded down to the nearest whole share. The stock options and RSUs granted to non-employee directors upon the non-employee director’s initial election or appointment to our Board of Directors vest in equal quarterly installments over a three-year period following the date of grant, generally subject to such director’s continued service on each vesting date.
At the time of our 2023 annual meeting of stockholders, each of our then-serving non-employee directors, all of whom continued in office, was eligible to receive annual equity awards in the form of both (a) a stock option to purchase the lesser of (i) 22,500 shares of common stock or (ii) a number of shares of common stock having a grant date fair value equal to $125,000, with the number of shares of common stock determined in accordance with ASC Topic 718, rounded down to the nearest whole share and (b) RSUs representing the lesser of (i) 22,500 shares of common stock or (ii) a number of shares of common stock equal to (a) $125,000 divided by (b) the closing sales price per share of our common stock on Nasdaq on the grant date, rounded down to the nearest whole share. All of our non-employee directors then serving on the Board of Directors, all of whom are still serving on our Board of Directors, were granted both an option to purchase 18,355 shares of our common stock and 14,467 RSUs on June 8, 2023, the date of our 2023 annual meeting of stockholders. Dr. Huber’s RSU award was subsequently rescinded in connection with his
 
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appointment as our President and Chief Executive Officer and the grant of additional equity awards in accordance with his employment offer letter, in order to comply with the per-participant award limitations specified in the Mersana Therapeutics, Inc. 2017 Stock Incentive Plan, or the 2017 Stock Incentive Plan. Additionally, following Ms. Protopapas’ retirement as our President and Chief Executive Officer effective September 10, 2023, pursuant to her retirement and separation agreement with us, our Board of Directors granted Ms. Protopapas equity awards intended to represent the service-period pro-rated portions of the annual equity awards awarded to our non-employee directors, in light of her continued service as a non-employee director following her retirement. On September 11, 2023, Ms. Protopapas was granted both an option to purchase 16,643 shares of our common stock and 16,643 RSUs. The stock options and RSUs granted to our non-employee directors on an annual basis (including those granted to Ms. Protopapas in September 2023) vest in full upon the earlier of the first anniversary of the date of grant or the date of the following annual meeting of stockholders, generally subject to the director’s continued service on each vesting date.
Furthermore, under our NED Compensation Policy each non-employee director may elect to convert all of his or her cash compensation for each calendar quarter in a year into either shares of common stock, or a Stock Retainer Grant, or a stock option to purchase shares of common stock, or an Option Retainer Grant. Any such election to convert cash compensation is referred to as a Retainer Grant Election. Each Retainer Grant Election must be submitted to our Chief Financial Officer in writing by no later than December 31 preceding each calendar year to which such Retainer Grant Election shall apply. A non-employee director may only make a Retainer Grant Election during a period in which Mersana is not in a quarterly or special blackout period under its insider trading policy and the non-employee director is not aware of any material non-public information. Once a Retainer Grant Election is properly submitted, it will be in effect for the full calendar year covered by the Retainer Grant Election. If a non-employee director timely makes a Retainer Grant Election, then on the first business day following the end of each calendar quarter, any non-employee director electing to receive a Stock Retainer Grant will be granted a number of shares of our common stock equal to (a) the aggregate amount of cash compensation otherwise payable to such non-employee director for the calendar quarter divided by (b) the closing sales price per share of our common stock on Nasdaq on the last day of such calendar quarter (or, if such date is not a market trading day, on the first market trading day thereafter), rounded down to the nearest whole share, and any non-employee director electing an Option Retainer Grant will be granted a stock option to purchase a number of shares of common stock having a grant date fair value equal to the aggregate amount of cash compensation otherwise payable to such non-employee director for such calendar quarter, with the number of shares of common stock determined in accordance with ASC Topic 718, rounded down to the nearest whole share. Each Stock Retainer Grant and Option Retainer Grant will be fully vested on the applicable grant date. For 2023, each of Dr. Dere and Mr. Mott elected to receive Stock Retainer Grants, and each of Mr. Alleva and Drs. Hege and Huber (during such period that he was a non-employee director) elected to receive Option Retainer Grants. The grants to our directors electing to receive equity awards in lieu of cash retainers for service in 2023 were made on April 3, 2023, July 3, 2023, October 2, 2023 and January 2, 2024. Each of Dr. Hack and Mses. Diaz and Protopapas (during such period that she was a non-employee director) received cash compensation in the year ended December 31, 2023.
All stock options granted to our non-employee directors pursuant to the NED Compensation Policy are non-statutory stock options granted pursuant to our 2017 Stock Incentive Plan, with an exercise price per share equal to the closing price of our common stock on Nasdaq on the date of grant and a term of 10 years from the date of grant (subject to earlier termination in connection with a termination of service).
A non-employee director may decline all or any portion of his or her compensation under the NED Compensation Policy by giving notice to us prior to the date such cash is earned or such equity awards are to be granted, as the case may be. None of our non-employee directors declined any of their compensation under the NED Compensation Policy in 2023.
The following table sets forth a summary of the compensation we paid to our non-employee directors during 2023. Each of Ms. Protopapas, our former President and Chief Executive Officer, who served in such position until September 10, 2023, and Dr. Huber, our current President and Chief Executive Officer, who assumed such position on September 11, 2023, received compensation for their services as a non-employee director during the part of 2023 that they served in such capacity and not as an employee. The
 
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compensation received by Ms. Protopapas and Dr. Huber for their respective service as a non-employee director is included and described in the 2023 Summary Compensation Table and accompanying narrative description in the section entitled “Executive Compensation” below.
Name(1)
Fees
Earned or
Paid in Cash
($)(2)
Stock Awards
($)(3)
Option Awards
($)(4)
Total
($)
Lawrence M. Alleva
59,000 124,995 124,930 308,925
Willard Dere, M.D.
55,500 124,995 124,930 305,425
Allene M. Diaz
45,000 124,995 124,930 294,925
Andrew A. F. Hack, M.D., Ph.D.
47,500 124,995 124,930 297,425
Kristen M. Hege, M.D.
43,500 124,995 124,930 293,425
David Mott
80,000 124,995 124,930 329,925
(1)
The aggregate number of shares of our common stock underlying stock options outstanding as of December 31, 2023 for non-employee members of the Board of Directors were: Mr. Alleva: 222,007; Dr. Dere: 183,476; Ms. Diaz: 113,046; Dr. Hack: 198,793; Dr. Hege: 229,242; and Mr. Mott: 207,267. The aggregate number of shares of our common stock underlying RSUs outstanding as of December 31, 2023 for non-employee members of the Board of Directors were 14,467 shares for each of Drs. Dere, Hack and Hege, Messrs. Alleva and Mott and Ms. Diaz.
(2)
Amounts represent cash fees earned by or paid to non-employee directors for 2023, including cash fees Dr. Dere and Mr. Mott elected to receive in the form of shares of common stock and cash fees Mr. Alleva and Dr. Hege elected to receive in the form of stock options, in each case which equity awards were granted on April 3, 2023, July 3, 2023, October 2, 2023 and January 4, 2024, as set forth in the table below.
Name
Cash Fees
Paid in the
Form of Equity
($)
Shares
Subject to
Stock
Options Granted
in Respect of
Cash Fees
(#)
Shares of
Common
Stock
Granted in
Respect of
Cash Fees
(#)
Lawrence M. Alleva
58,927 31,726
Willard Dere, Ph.D.
55,493 24,715
Kristen M. Hege, M.D.
43,439 23,075
David Mott
79,998 35,628
For such directors, amounts represent the aggregate grant date fair value of stock option awards and shares of common stock granted pursuant to such non-employee director’s election to receive their annual retainer fees in the form of a stock option or shares of common stock, computed in accordance with ASC Topic 718 and excluding the effect of estimated forfeitures. The assumptions used in the valuation of these equity awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report.
(3)
Amounts represent the aggregate grant date fair value of RSU awards granted to our non-employee directors in 2023, computed in accordance with ASC Topic 718 and excluding the effect of estimated forfeitures. The assumptions used in the valuation of these RSU awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report. Pursuant to SEC rules, the value of shares of common stock granted to Dr. Dere and Mr. Mott in connection with their election to receive their annual retainer fees in the form of shares of common stock has not been included in this column and instead the amount of such retainers are included under “Fees Earned or Paid in Cash.”
(4)
Amounts represent the aggregate grant date fair value of stock option awards granted to our non-employee directors in 2023, computed in accordance with ASC Topic 718 and excluding the effect of estimated forfeitures. The assumptions used in the valuation of these option awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report. Pursuant to SEC rules, the value of stock options granted to Mr. Alleva and Dr. Hege in connection with their election to receive their
 
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annual retainer fees in the form of stock options has not been included in this column and instead the amount of such retainers are included under “Fees Earned or Paid in Cash.”
Amendments to NED Compensation Policy
On December 15, 2023, upon the recommendation of the Compensation Committee, our Board of Directors approved the amendment of our NED Compensation Policy, or the Amended NED Compensation Policy. Under the Amended NED Compensation Policy, the cash retainer fees payable to our non-employee directors for service on our Board of Directors in 2024 did not change, and the ability to make a Retainer Grant Election to receive either stock options or shares of common stock in lieu of cash retainer fees did not change. However, under the Amended NED Compensation Policy, the initial equity award for which any newly elected or appointed non-employee director is eligible will take the form of a stock option to purchase 110,000 shares of our common stock. The shares subject to such initial equity award will vest in equal quarterly installments over a three-year period, subject to the non-employee director’s continuous service as a director on each vesting date. Additionally, under the Amended NED Compensation Policy, the annual equity award to be granted to each non-employee director who continues to serve as a non-employee director following each annual meeting of stockholders will take the form of a stock option to purchase 55,000 shares of common stock. The shares subject to such annual equity award will vest in full upon the earlier of the first anniversary of the date of grant or the date of the following annual meeting of stockholders of the Company, subject to the non-employee director’s continuous service as a director on each vesting date.
All stock options granted to our non-employee directors pursuant to the Amended NED Compensation Policy will be nonstatutory stock options granted pursuant to our 2017 Stock Incentive Plan, with an exercise price per share equal to the closing price of our common stock on Nasdaq on the date of grant and a term of 10 years from the date of grant (subject to earlier termination in connection with a termination of service).
 
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EXECUTIVE OFFICERS
Below is a list of the names, ages, positions, and a brief account of the business experience of the individuals who serve as our executive officers.
Name
Age
Position
Martin Huber, M.D.
64
Chief Executive Officer and President; Director
Mohan Bala, Ph.D.
59
Senior Vice President, Chief Development Officer
Alejandra Carvajal
50
Senior Vice President, Chief Legal Officer
Brian DeSchuytner
46
Senior Vice President, Chief Operating Officer and Chief Financial Officer
Timothy B. Lowinger, Ph.D.
60
Senior Vice President, Chief Science and Technology Officer
Tushar Misra, Ph.D.
64
Senior Vice President, Chief Manufacturing Officer
Executive Officer Biographies
Biographical information, including business experience and public company board experience during the last five years, for our current executive officers is set forth below. Biographical information for Martin Huber, M.D., our President and Chief Executive Officer, is included above under “Proposal No. 1 — Election of Directors — Nominees for Election as Class I Directors.”
Mohan Bala, Ph.D., has served as our Senior Vice President, Chief Development Officer since September 2023, and prior to that he served as our Senior Vice President, Strategic Product Planning & Program Leadership from October 2021 to September 2023. Prior to joining Mersana, Dr. Bala served as Chief Operating Officer at Constellation Pharmaceuticals from November 2020 to September 2021 and as Senior Vice President, Program Leadership from November 2019 to November 2020. Prior to that, from July 2018 to November 2019, Dr. Bala was Vice President, Development Program Lead, Immuno-Oncology at TESARO, Inc., or Tesaro, where he had earlier served as Vice President, Product Value. Dr. Bala received a B.Tech. from IIT Madras (India) and his M.B.A. and Ph.D. in management science from the University of Chicago.
Alejandra Carvajal has served as our Senior Vice President, Chief Legal Officer since April 2021. Prior to joining Mersana, Ms. Carvajal served as the Chief Legal Officer and General Counsel of Momenta Pharmaceuticals, Inc., or Momenta, a biotechnology company, from October 2018 to March 2021. From June 2017 to October 2018, she served as the Vice President, Deputy General Counsel of Momenta. Ms. Carvajal received a B.A. cum laude from Harvard University and a J.D. cum laude from The Georgetown University Law Center.
Brian DeSchuytner has served as our Senior Vice President, Chief Operating Officer and Chief Financial Officer since September 2023 and prior to that served as our Senior Vice President, Chief Financial Officer from October 2021 to September 2023 and as our Senior Vice President, Finance and Product Strategy, from June 2019 until October 2021. Prior to joining Mersana, he served as Vice President, ZEJULA Commercial at TESARO from January 2017 to June 2019. Mr. DeSchuytner received a B.A. in biophysical chemistry from Dartmouth College and an M.B.A., concentrating in finance and health care management, from the Wharton School of the University of Pennsylvania.
Timothy B. Lowinger, Ph.D., has served as our Senior Vice President, Chief Science and Technology Officer since August 2019, and prior to that served as our Senior Vice President, Chief Scientific Officer since February 2008. Dr. Lowinger received a B.Sc. (Hons.) in chemistry and a Ph.D. in synthetic organic chemistry from the University of British Columbia.
Tushar Misra, Ph.D., has served as our Senior Vice President, Chief Manufacturing Officer since August 2021. Prior to joining Mersana, Dr. Misra served as Executive Vice President, Head of Technical Development & Manufacturing at Laronde, a biotechnology company, from March 2020 to August 2021. From November 2018 to January 2020, he served as Senior Vice President, Technical Operations at Wave Life Sciences Ltd., a genetic medicines company. Prior to that, from July 2012 to October 2018, Dr. Misra worked at Takeda Pharmaceutical Company, a pharmaceutical company, in several positions of increasing seniority, most recently as Vice President & Head, Global Oncology and Biologics Operations. Dr. Misra received a B.Sc. with honors from the National Institute of Technology, Rourkela, India, and M.S. and Ph.D. degrees in chemical engineering from the University of Rhode Island.
 
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PROPOSAL NO. 2 — ADVISORY VOTE ON EXECUTIVE COMPENSATION
We are providing our stockholders the opportunity to vote to approve, on an advisory, non-binding basis, the compensation of our named executive officers as disclosed in this proxy statement in accordance with the SEC’s rules. This proposal, which is commonly referred to as “say-on-pay,” is required by the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, or the Dodd-Frank Act, which added Section 14A to the Exchange Act. Our executive compensation program is designed to attract and retain qualified and talented executives, motivate such executives to achieve our business goals and reward them for short- and long-term performance with a simple and clear compensation structure. Under this program, our named executive officers are rewarded for the achievement of our short- and long-term performance, which we believe serves to enhance short- and long-term value creation for our stockholders. The program contains elements of cash and equity-based compensation and is designed to align the interests of our executives with those of our stockholders and emphasize our pay-for-performance philosophy.
The section of this proxy statement titled “Executive Compensation,” including “— Compensation Discussion and Analysis,” describes in detail our executive compensation program and the decisions made by the Compensation Committee. As we describe in greater detail in the “— Compensation Discussion and Analysis” section, our executive compensation program rewards value creation for stockholders and progress towards achieving our business goals. At the same time, we believe our program does not encourage excessive risk-taking by management. While we do not have a formal or informal policy for allocating between long-term and short-term compensation, between cash and non-cash compensation or among different forms of non-cash compensation, we generally strive to provide our named executive officers with a mix of short-term and long-term performance-based incentives to encourage consistently strong performance, and our Board of Directors believes that this link between compensation and the achievement of our near- and long-term business goals has helped drive our performance over time.
Our Board of Directors is asking stockholders to approve a non-binding advisory vote on the following resolution:
RESOLVED, that the compensation paid to the Company’s named executive officers, as disclosed pursuant to the compensation disclosure rules of the Securities and Exchange Commission, including the compensation discussion and analysis, the compensation tables and any related material disclosed in the Proxy Statement, is hereby approved.
As an advisory vote, this proposal is not binding. The outcome of this advisory vote does not overrule any decision by us or our Board of Directors (or any committee thereof), create or imply any change to the fiduciary duties of the company or our Board of Directors (or any committee thereof), or create or imply any additional fiduciary duties for the company or our Board of Directors (or any committee thereof). However, the Compensation Committee and Board of Directors value the opinions expressed by our stockholders in their vote on this proposal and intend to consider carefully the outcome of the vote when making future compensation decisions for named executive officers. In 2021, our Board of Directors recommended, our stockholders agreed and our Board of Directors thereafter concluded that our stockholders cast an advisory vote annually on the executive compensation of our named executive officers. The next stockholder advisory “say-on-frequency” vote will occur at our 2027 annual meeting of stockholders.
Recommendation of the Board of Directors
OUR BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS
VOTE TO APPROVE THE COMPENSATION PAID TO OUR NAMED EXECUTIVE
OFFICERS BY VOTING “FOR” THIS PROPOSAL.
 
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EXECUTIVE COMPENSATION
Compensation Discussion and Analysis
This Compensation Discussion and Analysis, or CD&A, describes our compensation philosophy, the material elements and objectives of our compensation programs for our named executive officers and the factors, rationale and processes used to determine compensation for our named executive officers in 2023.
Our named executive officers for the year ended December 31, 2023 are as follows:
Named Executive Officer
Position
Martin Huber, M.D. President and Chief Executive Officer; Director(1)
Anna Protopapas Former President and Chief Executive Officer; Director (2)
Brian DeSchuytner Senior Vice President, Chief Operating Officer and Chief Financial Officer(3)
Mohan Bala, Ph.D. Senior Vice President, Chief Development Officer(4)
Alejandra Carvajal Senior Vice President, Chief Legal Officer
Timothy B. Lowinger, Ph.D. Senior Vice President, Chief Science and Technology Officer
Arvin Yang, M.D. Former Senior Vice President, Chief Medical Officer(5)
(1)
Dr. Huber’s employment as our President and Chief Executive Officer commenced on September 11, 2023. Until September 10, 2023, Dr. Huber served as a non-employee director, and he continued to serve as a director following his appointment as our President and Chief Executive Officer.
(2)
Ms. Protopapas retired as our President and Chief Executive Officer effective September 10, 2023. Following such time, she continued to serve as a non-employee director.
(3)
Mr. DeSchuytner’s title was changed from Senior Vice President, Chief Financial Officer to Senior Vice President, Chief Operating Officer and Chief Financial Officer on September 5, 2023.
(4)
Dr. Bala’s title was changed from Senior Vice President, Product Strategy to Senior Vice President, Chief Development Officer, and he was designated an executive officer, on September 5, 2023.
(5)
Dr. Yang served as our Senior Vice President, Chief Medical Officer until September 30, 2023.
Executive Summary
Business Overview
We are a clinical-stage biopharmaceutical company focused on developing antibody-drug conjugates, or ADCs, that offer a clinically meaningful benefit for cancer patients with significant unmet need. We have leveraged decades of industry learnings to develop two proprietary and differentiated ADC platforms: Dolasynthen and Immunosynthen. Dolasynthen is our cytotoxic ADC platform that is designed to generate site-specific, homogeneous ADCs. Dolasynthen allows for drug-to-antibody ratios, or DARs, to be optimized for specific targets and utilizes a proprietary auristatin payload that has been shown clinically to avoid dose-limiting severe neutropenia, peripheral neuropathy and ocular toxicity. Immunosynthen is our proprietary STING (stimulator of interferon genes)-agonist platform that is designed to generate systemically administered ADCs that locally activate STING signaling in both antigen-expressing tumor cells and in tumor-resident immune cells to unlock the anti-tumor potential of innate immune stimulation. We are utilizing these platforms to generate ADC product candidates for our company and collaborators that we believe have the potential to improve upon today’s standards of care.
Although currently approved ADCs are providing substantial benefits to certain patient populations and more product candidates are in development, we believe significant platform and payload limitations are preventing this therapeutic class from realizing its full potential. We are focused on developing novel platforms and payloads that can be utilized to create ADCs with meaningfully improved safety and efficacy
 
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for patients with a range of cancers. We believe that executing against the following strategic objectives will help us achieve our goal:

Leverage Our ADC Platforms While Continuing to Innovate.   We believe that our two proprietary ADC platforms, Dolasynthen and Immunosynthen, can be utilized to develop impactful cytotoxic and immunostimulatory ADCs, respectively. These platforms were designed to address key limitations of ADCs today by reducing dose-limiting platform toxicities, avoiding payload resistance mechanisms and providing new payload alternatives. We believe continued platform, payload and product candidate innovation may enable us to become an ADC leader, and we have built a core team of internal research and discovery personnel that is seeking new and improved approaches to ADC design. Through these efforts, we aspire to identify and capitalize on opportunities to further differentiate our company within the field of ADCs and to maintain a robust and differentiated pipeline of product candidates.

Advance the Development of XMT-1660.   XMT-1660 is a B7-H4-targeting Dolasynthen ADC. We believe XMT-1660 has the potential to address unmet needs for patients with a range of cancers that express B7-H4. We continue to advance our Phase 1 clinical trial of XMT-1660 in patients with various tumors, including breast, endometrial and ovarian cancers.

Advance the Development of XMT-2056.   XMT-2056 is a systemically administered Immunosynthen ADC that is designed to target a novel epitope of HER2 and to locally activate STING signaling in both tumor-resident immune cells and in antigen-expressing tumor cells in a target-dependent manner. We believe this approach may enable the treatment of patients with HER2-high or -low tumors as monotherapy and in combination with standard-of-care agents. In the fourth quarter of 2023, we announced the resolution of a U.S. Food and Drug Administration, or FDA, clinical hold on our Phase 1 clinical trial of XMT-2056 in previously treated patients with advanced or recurrent solid tumors expressing HER2.

Collaborate with Leading Organizations.   We believe that our ADC platforms and product candidates can be leveraged by existing and future collaborators to address significant unmet needs for broad global patient populations. We have established strategic research and development collaborations with Johnson & Johnson and Merck KGaA for the research, development and commercialization of a select number of ADC product candidates leveraging our Dolasynthen and Immunosynthen platforms, respectively. We have also granted GSK an exclusive option for an exclusive global license to co-develop and commercialize XMT-2056.
2023 Financial and Business Highlights
As described in further detail below, the events of 2023 had a significant impact on our business and led to the redefinition of our strategy by the end of that year. At the beginning of 2023, our business was largely focused on the advancement of UpRi, which was at the time our lead product candidate, toward a potential product approval. We were also focused on the development of our next-generation ADCs, XMT-1660, which leverages our Dolasynthen platform, and XMT-2056, which leverages our Immunosynthen platform, while also supporting our collaborators. After failing to meet the primary endpoint in the UPLIFT trial described below, we discontinued the clinical development of UpRi and dedicated ourselves to understanding our collective UpRi data, as well as our available clinical and non-clinical data relating to our first-generation Dolaflexin and our next-generation Dolasynthen ADC platforms. Based on lessons learned from that effort, we announced our new strategy focused on advancing the clinical development of XMT-1660 and restarting our XMT-2056 Phase 1 clinical trial following FDA’s lifting of a clinical hold, while continuing to support the progress of our platform collaborations. The events and developments highlighted below all contributed to the compensation decisions made by the Compensation Committee and the Board of Directors relating to performance in 2023:

In March 2023, we announced that the U.S. Food and Drug Administration, or FDA, had placed our Phase 1 trial of XMT-2056 on clinical hold following our communication to FDA that we were voluntarily suspending the trial due to a Grade 5 (fatal) serious adverse event that was deemed to be related to XMT-2056. We spent the next several month analyzing available data relating to XMT-2056, including patient cytokine and pharmacokinetic data, in order to respond to the FDA’s clinical hold questions, which ultimately resulted in the lifting of the clinical hold in October 2023.
 
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In June 2023, we announced that the FDA had issued a partial clinical hold pausing new patient enrollment in UP-NEXT and UPGRADE-A, our then-ongoing clinical trials of UpRi, in platinum-sensitive ovarian cancer. The partial clinical hold followed our submission of an aggregate safety report of all patients dosed with UpRi (approximately 560 patients) evaluating bleeding events, which aggregate safety report reflected our assessment that serious bleeding events appeared to occur in patients receiving UpRi at a higher rate than background.

In July 2023, we announced that our Phase 2 UPLIFT clinical trial of UpRi, which was at that time our lead product candidate, did not meet its primary endpoint. At the same time, we announced decisions to reprioritize our areas of focus and to discontinue clinical development of UpRi. In connection with these decisions, our Board of Directors approved certain expense reduction measures, including a reduction of approximately 50% of our then-current employee base, or the Restructuring.

On September 1, 2023, Anna Protopapas, who was then serving as our President and Chief Executive Officer, provided our Board of Directors with notice of her desire and intention to retire, and on September 6, 2023, we announced Ms. Protopapas’ retirement effective as of September 10, 2023 and entered into a retirement and separation agreement, or the Protopapas Retirement Agreement, with Ms. Protopapas; see the section below titled “Executive Compensation — Employment Arrangements — Retirement and Separation Agreement with Ms. Protopapas.” Ms. Protopapas continues to serve as a non-employee member of our Board of Directors.

On September 6, 2023, we also announced the appointment of Martin Huber, M.D., as our President and Chief Executive Officer, effective as of September 11, 2023. Dr. Huber continues to serve as a member of our Board of Directors. At the same time, we announced, among other things, that Brian DeSchuytner, who had previously served as our Senior Vice President, Chief Financial Officer, had been appointed our Senior Vice President, Chief Operating Officer and Chief Financial Officer; and that Mohan Bala, Ph.D., who had previously served as our Senior Vice President, Strategic Product Planning and Program Leadership, had been appointed our Senior Vice President, Chief Development Officer. Additionally, we and Arvin Yang, M.D., who had previously served as our Senior Vice President, Chief Medical Officer, had mutually agreed that Dr. Yang would depart on September 30, 2023; in connection with his departure, Dr. Yang was eligible for severance pursuant to his letter agreement with us, as described more fully in the section entitled “Executive Compensation — Payments on Termination of Employment or Change in Control Benefits” below.
For the remainder of 2023, we focused on completing our Restructuring and UpRi wind-down efforts (which were substantially completed by December 31, 2023) and dedicated our efforts to advancing XMT-1660, restarting the XMT-2056 Phase 1 clinical trial and progressing our collaborations. We are currently enrolling patients in dose escalation and backfill cohorts that are designed to assess the safety and tolerability of XMT-1660 and to optimize dose and schedule selection for further investigation in later stages of clinical development. Additionally, we are restarting the XMT-2056 phase 1 clinical trial. And finally, we continue to support our collaborators as they seek to discover and develop novel ADCs based on our Dolasynthen and Immunosynthen platforms.
Compensation Governance Highlights
Our Compensation Committee regularly reviews our executive compensation programs and practices and those of other companies in our industry and our executive compensation peer group, as well as evolving trends in executive compensation, to ensure that our programs and practices continue to reflect our philosophy and remain competitive to encourage high performance, the execution of our strategy and the advancement of our preclinical and clinical programs. We believe that our compensation programs are grounded in sound practices and processes that align with industry best practices. Listed below are some of the compensation practices we employ in our executive compensation program that reinforce or are reflective of our philosophy.
 
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What We Do
What We Don’t Do

Maintain an industry- and size-appropriate peer group for benchmarking compensation

Tie cash-based incentives to achievement of Company objectives

Provide a majority of compensation in long-term equity incentives with multi-year vesting schedules

Provide a competitive mix of fixed (e.g., base salary) and variable (e.g., bonus) compensation

Evaluate the risk profile of our pay programs

Set robust executive officer and non-employee director stock ownership guidelines

Maintain a comprehensive compensation recoupment (clawback) policy applicable to both cash and equity incentive compensation

Consult with an independent compensation advisor

No employment arrangements that guarantee a certain compensation level or employment term

No guaranteed salary increases or bonuses

No single-trigger vesting in connection with a change-in-control for equity awards

No special perquisites or personal benefits for executives

No retirement plans other than our 401(k) and no special health or welfare benefits for executives

No hedging or pledging or speculative transactions in our securities

No tax gross-up provisions
Say-on-Pay Vote Results & Stockholder Outreach
At our 2023 annual meeting of stockholders, or the 2023 Annual Meeting, we conducted a non-binding advisory vote on the compensation of our named executive officers, commonly referred to as a “say-on-pay” vote, in accordance with the Dodd-Frank Act. Approximately 77% of the votes cast by stockholders on this proposal, excluding broker non-votes and abstaining votes, were cast in favor of the compensation paid to our named executive officers in the year ended December 31, 2022.
We engage in regular outreach with our stockholders throughout each year, including in advance of our annual meetings of stockholders. As part of these stockholder engagement efforts, in 2023, we held discussions with stockholders representing approximately 66% of our outstanding common stock. During the course of the conversations we held with stockholders in 2023, no stockholders offered any feedback on our executive compensation practices.
Our Compensation Committee and Board of Directors will continue to consider stockholder input and monitor our executive compensation program to ensure it aligns the interests of our named executive officers with the interests of our stockholders and adequately addresses any stockholder concerns that may be expressed in future votes. Consistent with the recommendation of our Board of Directors and the preference of our stockholders as reflected in the non-binding advisory vote on the frequency of future “say-on-pay” votes conducted at our 2021 annual meeting of stockholders, our stockholders will continue to have an opportunity annually to cast an advisory vote in connection with compensation for our named executive officers.
Executive Compensation Philosophy and Objectives
Our executive compensation program is designed to attract, retain and reward talented executives, to incentivize them based on the achievement of key performance goals, and to align their interests with the interests of our stockholders. We operate in a highly competitive and rapidly evolving industry and in a principal geography — the greater Boston, Massachusetts area — in which competition for the highly-skilled personnel capable of enabling us to achieve our mission and execute on our corporate strategy is particularly fierce. In order to help us achieve our short- and long-term financial and operational goals, we intend for total compensation, which we define as base salary, incentive cash compensation, equity compensation and benefits, to be competitive in the biopharmaceutical marketplace in which we compete for talent.
 
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The Compensation Committee retains the authority and flexibility to vary the compensation of any individual named executive officer from the targeted pay framework, based on the unique responsibilities and requirements of his or her position, his or her experience and qualifications, internal parity relative to similar positions within our company, and individual or Company performance relative to our performance goals and to our selected peer group to ensure appropriate pay-for-performance alignment. While we do not have a formal or informal policy for allocating between long-term and short-term compensation, between cash and non-cash compensation or among different forms of non-cash compensation, historically, a majority of the compensation for our named executive officers is long-term compensation, balanced with sufficient short-term incentives to encourage consistently strong performance.
Executive Compensation Process
Role of the Compensation Committee
Pursuant to its charter and in accordance with applicable Nasdaq listing standards, our Compensation Committee is responsible for assisting our Board of Directors in fulfilling its responsibilities relating to oversight of the compensation and benefits of our executive officers, employees, and directors and administering our compensation, benefit and equity-based plans. This responsibility includes oversight of the philosophy and policies that govern our overall management compensation and benefits and of the goals and objectives relevant to compensating our executive officers. Our Compensation Committee also oversees the preparation of our CD&A and our compliance with rules regarding our stockholder advisory say-on-pay votes and our stockholder advisory vote to determine the frequency with which we hold say-on-pay votes. Our Compensation Committee also reviews and establishes the compensation of our executive officers, other than our Chief Executive Officer, and makes recommendations to our Board of Directors with respect to our Chief Executive Officer’s compensation.
Our Compensation Committee periodically reviews and evaluates the components and effectiveness of our executive compensation program to ensure that our executive compensation program is consistent with our goals and aligned with our executive compensation peer group and the marketplace in which we compete for executive talent. In conducting these reviews and evaluations, our Compensation Committee utilizes the services of an independent compensation consultant, Pearl Meyer & Partners, LLC, or Pearl Meyer, to provide advice regarding executive compensation, including with respect to the composition of our peer group, to gather peer group and other relevant executive compensation information and trends, and to analyze this information.
Our Compensation Committee generally reviews and approves the base salary, annual cash bonus and annual long-term equity incentive awards for our executive officers at the beginning of each calendar year and will consider and approve, or recommend for approval by the Board of Directors, other compensation for our executive officers on an ad hoc basis.
Role of Management
Our Compensation Committee works with and receives information and analyses from our Chief Executive Officer and other members of our management team, including within our Human Resources, Finance and Legal departments, and considers such information and analyses in determining the structure and amount of compensation to be paid to our executive officers. Our Chief Executive Officer makes recommendations to our Compensation Committee regarding the base salaries, annual cash bonuses and equity incentive awards for our executive officers other than himself or herself. Our management team provides information to our Compensation Committee regarding executive officer performance, market and peer group data and information, and management’s recommendations and proposals regarding executive officer compensation programs and decisions affecting base salaries, cash bonuses, long-term equity incentive compensation and other compensation-related matters, including the specific performance goals to be used in our annual cash bonus program. Our Human Resources department periodically purchases third-party compensation benchmark surveys and related industry information and, in cooperation with Pearl Meyer, prepares and provides analyses to assist our Compensation Committee’s evaluation and comparison of each element of executive compensation.
 
33

 
Our Compensation Committee may take into account these recommendations and information provided by our independent compensation consultant but is ultimately responsible for determining (or recommending, in the case of our Chief Executive Officer) the compensation of our executive officers.
Members of management, including certain of our executive officers, attend portions of our Compensation Committee’s meetings; however, executive officers, including our Chief Executive Officer, are not present during discussions and decisions regarding their respective performance and compensation.
Role of Compensation Consultant
Our Compensation Committee has the sole authority and right to engage, at our expense, one or more independent compensation consultants and advisors to assist the Compensation Committee in performing its responsibilities, including to obtain information, analysis and advice regarding our executive compensation program and decision-making. For 2023 and 2024, our Compensation Committee has engaged Pearl Meyer to assist it in this regard and sets the compensation for and oversees the work of Pearl Meyer. Pearl Meyer has not been retained by management to perform any work for our company other than projects that are performed at the direction of or with the approval of the Compensation Committee and that are intended to support discussions with and decisions by the Compensation Committee.
During 2023, Pearl Meyer attended meetings of and provided the following services to our Compensation Committee, including with respect to evaluations and decisions regarding 2023 and 2024 executive officer compensation:

reviewing and recommending revisions to the executive compensation peer group we used in 2023 and the peer group we are using in 2024;

providing compensation information for our peer group companies and competitive data for our executive officers, directors and our employees generally;

reviewing and recommending the base salaries, annual cash incentive award opportunities and long-term equity incentive compensation opportunities of our executive officers;

providing guidance on the structure of executive officer equity compensation, including whether to use a percentage of shares outstanding or value-based approach;

evaluating how our executive compensation compares to our performance and to the executive compensation of the companies in our peer group;

providing guidance on trends in executive officer compensation, corporate governance and regulatory issues and developments;

providing analysis of our equity plan utilization and related metrics;

reviewing our peer group and market equity compensation practices; and

reviewing the “Compensation Discussion and Analysis” section of our proxy statement and reviewing and providing data for the other compensation-related sections of our proxy statement.
In determining to engage Pearl Meyer, our Compensation Committee considered Pearl Meyer’s independence, taking into consideration relevant factors, including the absence of other services provided to Mersana by Pearl Meyer, the amount of fees Mersana paid to Pearl Meyer as a percentage of its total revenue, Pearl Meyer’s policies and procedures that are designed to prevent conflicts of interest, any business or personal relationships Pearl Meyer’s individual compensation advisors have with any executive officer of the Company or with any member of our Compensation Committee and any stock of the Company owned by Pearl Meyer and its individual compensation advisors. Our Compensation Committee determined, based on its analysis in light of all relevant factors, including the factors listed above, that the work of Pearl Meyer and its individual compensation advisors as compensation consultants to our Compensation Committee has not created any conflicts of interest, and that Pearl Meyer is independent pursuant to the independence standards set forth in the Nasdaq listing standards promulgated pursuant to Section 10C of the Exchange Act.
 
34

 
Peer Group Selection and Benchmarking
To inform executive compensation decisions and ensure the competitiveness of our executive compensation programs, our Compensation Committee benchmarks our executive compensation against the executive compensation of a peer group of publicly traded national and regional companies in the biopharmaceutical and biotechnology industries. Our Compensation Committee, with the assistance of Pearl Meyer, selects companies to include in our executive compensation peer group that on balance generally meet the following criteria at the time of selection:

companies with a market capitalization similar to ours, such that we are also positioned near the median of the peer group;

companies with both a stage of product development and clinical advancement and operating size (e.g., number of employees and annual research and development expense) that are similar to ours;

companies with a similar therapeutic focus (oncology) to us; and

companies that are headquartered in Massachusetts and are not co-domiciled.
Our Compensation Committee strives to identify a peer group of companies that generally reflects Mersana’s profile. Our market capitalization, employee headcount and annual research and development related expenses may change year over year, and the companies within our peer group may undergo similar changes, be acquired or, in some instances, reach a different stage of overall development or change therapeutic focus. Accordingly, with the assistance of Pearl Meyer and our management, our Compensation Committee annually reviews and, as appropriate, revises our peer group composition to ensure it continues to represent our overall profile on these metrics.
For purposes of executive compensation for 2023, our Compensation Committee worked with Pearl Meyer to evaluate our peer group in September 2022. During their review, our Compensation Committee and Pearl Meyer considered how, following their prior evaluation of our peer group in September 2021, the market capitalization of each of Codiak BioSciences, Inc., Rubius Therapeutics, Inc. and Syros Pharmaceuticals, Inc. had fallen significantly, below both our market capitalization and $100 million as of August 2022, and, therefore, no longer met our market capitalization criterion. In consultation with Pearl Meyer and management, in September 2022, our Compensation Committee modified our peer group to include three new oncology-focused companies, each headquartered in Massachusetts, that had a market capitalization, stage of development and stage of clinical advancement more similar to ours. The Compensation Committee selected the companies listed below as our executive compensation peers, or our 2023 Peer Group, to make executive compensation decisions following September 2023:
2023 Peer Group
Alaunos Therapeutics, Inc. Jounce Therapeutics, Inc.
Arcus Biosciences, Inc. Kura Oncology, Inc.
Cogent Biosciences, Inc.* Pieris Pharmaceuticals, Inc.
Cue Biopharma, Inc. Relay Therapeutics,
Foghorn Therapeutics, Inc.* Replimune Group, Inc.
Forma Therapeutics Holdings, Inc. Scholar Rock Holding Corporation
IGM Biosciences, Inc. Seres Therapeutics, Inc.*
ImmunoGen, Inc. TCR2 Therapeutics Inc.
Inovio Pharmaceuticals, Inc. Zymeworks, Inc.
*
The companies marked with an asterisk were added to our 2023 Peer Group. Alaunos Therapeutics, Inc. is the successor of ZIOPHARM Oncology, Inc. The following companies from our 2022 Peer Group were removed from our 2023 Peer Group for the reason described above: Codiak BioSciences, Inc.; Rubius Therapeutics, Inc. and Syros Pharmaceuticals, Inc.
For purposes of executive compensation for 2024, our Compensation Committee again worked with Pearl Meyer to re-evaluate our peer group in September 2023. During their review, our Compensation Committee and Pearl Meyer considered how, following their prior evaluation of our peer group in
 
35

 
September 2022, ImmunoGen, Inc. had become a commercial-stage company; the market capitalization of each of Arcus Biosciences, Inc., Cogent Biosciences, Inc., Kura Oncology, Inc., Relay Therapeutics, Inc., and Replimune Group, Inc. had increased significantly, both above our market capitalization and $750 million as of August 2023, and therefore no longer met our market capitalization criterion; the market capitalization of each of Alaunos Therapeutics, Inc. and Pieris Pharmaceuticals, Inc. had decreased significantly, both below our market capitalization and $100 million as of August 2023, and therefore no longer met our market capitalization criterion; Forma Therapeutics Holdings, Inc., Jounce Therapeutics, Inc. and TCR Therapeutics, Inc. had each been acquired and were no longer publicly traded companies; and Seres Therapeutics, Inc. had significantly increased its employee headcount and no longer met our operating size criterion. In consultation with Pearl Meyer and management, in September 2023, our Compensation Committee modified our peer group to include companies with a market capitalization and stage of development more similar to ours, prioritizing selecting peers headquartered in Massachusetts and not co-domiciled and aiming to position us at the median of the peer group with respect to market capitalization, and selected the companies listed below as our executive compensation peers, or our 2024 Peer Group, to make executive compensation decisions following September 2023:
2024 Peer Group
Adicet Bio, Inc.* Omega Therapeutics, Inc.*
Black Diamond Therapeutics, Inc.* Prelude Therapeutics Incorporated*
C4 Therapeutics, Inc.* Scholar Rock Holding Corporation
Cue Biopharma, Inc. Tango Therapeutics, Inc.*
Foghorn Therapeutics, Inc. TScan Therapeutics, Inc.*
IGM Biosciences, Inc. Verastem, Inc.*
Ikena Oncology, Inc.* Vor Biopharma, Inc.*
Inovio Pharmaceuticals, Inc. Werewolf Therapeutics, Inc.*
iTeos Therapeutics, Inc.* Zymeworks, Inc.
Monte Rosa Therapeutics, Inc.*
*
The companies marked with an asterisk were added to our 2024 Peer Group. The following companies from our 2023 Peer Group were removed from our 2024 Peer Group for the reasons described above: Alaunos Therapeutics, Inc.; Arcus Biosciences, Inc.; Cogent Biosciences, Inc.; Forma Therapeutics Holdings, Inc.; ImmunoGen, Inc.; Jounce Therapeutics, Inc.; Kura Oncology, Inc.; Pieris Pharmaceuticals, Inc.; Relay Therapeutics, Inc.; Replimune Group, Inc.; Seres Therapeutics, Inc. and TCR Therapeutics, Inc.
When setting executive pay levels, our Compensation Committee generally references competitive ranges of our peer group for cash compensation (base salary and annual performance-based cash bonuses) and equity incentive compensation. While we do not have a stated policy or principle for the allocation of compensation, we generally emphasize equity incentive compensation versus cash to retain our executives, align their interests with those of our stockholders and emphasize our pay-for-performance philosophy. Our Compensation Committee may adjust actual compensation levels with respect to our executives to reflect experience, performance levels and market factors as deemed appropriate by our Compensation Committee or the Board of Directors.
In addition to reviewing the executive compensation programs and practices of our peer group, because we compete for executive talent with many companies throughout the biopharmaceutical and biotechnology industries, our Compensation Committee also reviews and considers the executive compensation practices of companies in the broader biopharmaceutical and biotechnology sector as reported by Pearl Meyer or by comparable third parties through industry surveys and research.
Elements of Our Executive Compensation Program
There are three primary components of our executive compensation program:

base salary;
 
36

 

annual cash bonuses based on individual and corporate performance; and

equity incentive awards, in the form of stock options and restricted stock units, or RSUs.
In addition to these primary elements of executive compensation, we also offer our executive officers broad-based health and welfare benefits and 401(k) plan benefits consistent with the benefits we provide to our other full-time, salaried employees. Our Compensation Committee believes that each primary component of executive compensation must be evaluated and determined with reference to our peer group and other competitive market data, individual and corporate performance, our recruiting and retention goals, internal equity and consistency, and other factors and information it deems relevant. We strive to provide our executive officers with a balance of short-term and long-term equity incentives to encourage and reward consistently strong performance. Ultimately, the objective in setting the balance between long-term and short-term compensation is to ensure adequate base and short-term incentive compensation to attract and retain talent, while providing incentives to maximize long-term value for our Company and our stockholders.
These primary components of our executive compensation program are described in more detail below.
Base Salary
The purpose of base salary compensation is to attract and reward each executive with a competitive level of fixed cash compensation that is paid regularly throughout the year. Base salary is the only element of compensation that is fixed; the remainder and majority of each executive officer’s potential compensation is composed of variable compensation that is designed to incentivize shorter-term (annual) or longer-term performance of the Company.
In assessing what the market would pay as base salary for a given executive officer position, our Compensation Committee (and, in the case of our Chief Executive Officer, our Board of Directors) relies on compensation information from our executive compensation peer group, as well as compensation benchmark surveys we purchase (see the section titled “Peer Group Selection and Benchmarking” above). Our Compensation Committee targets the 50th percentile of our peer group for executive officer base salary compensation. An individual executive officer’s base salary, however, may vary from the 50th percentile peer group-level for the officer’s position based on the officer’s experience, knowledge, skills, education, performance and contributions to the Company. For example, for an executive officer that the Compensation Committee believes has extensive experience and greater knowledge and skills for the relevant position or has significantly contributed to our performance may have a base salary that is greater than the 50th percentile of our peer group for a comparable position. We do not provide any automatic base salary increases to our executive officers.
Our Compensation Committee, with input from our Chief Executive Officer as to executive officers other than herself or himself, reviews and evaluates each executive officer’s base salary during the fourth quarter of each year, and our Board of Directors, based on the recommendation of our Compensation Committee, reviews and evaluates our Chief Executive Officer’s base salary at the same time; final decisions regarding any changes to such base salary are typically finalized in the first quarter of the following year, retroactive to January 1. In connection with this review and evaluation, our Compensation Committee (or, in the case of our Chief Executive Officer, our Board of Directors) may adjust an executive officer’s base salary, if appropriate, based on the officer’s individual performance and contributions during the preceding year, changes or expected changes in the scope of the officer’s responsibilities, including as a result of a promotion, changes in the base salary range of compensation at our peer group companies, the growth of or changes in our operations and the expected ease or difficulty of replacing the executive with a well-qualified replacement. Our Compensation Committee and Board of Directors also take into consideration general compensation trends within the biotechnology and biopharmaceutical industries, including trends with respect to companies that are headquartered in the Boston, Massachusetts area or another significant biotechnology market.
2023 Base Salaries
In January 2023, our Compensation Committee (or our Board of Directors, in the case of Ms. Protopapas, who was then our Chief Executive Officer) reviewed and evaluated the base salaries of our
 
37

 
executive officers as compared to benchmarking data for our 2023 Peer Group and in light of individual performance and approved the annual base salary for each of our named executive officers shown in the below table. Following Ms. Protopapas’ retirement in September 2023, Dr. Huber was appointed our President and Chief Executive Officer effective as of September 11, 2023. Prior to the Board extending an offer of employment to Dr. Huber, our Compensation Committee reviewed and evaluated benchmarking data from our 2023 Peer Group before recommending to our Board of Directors that the base salary shown in the below table be approved for Dr. Huber.
Name
2022
Annual
Base
Salary
2023
Annual
Base
Salary
%
Increase
from
2022
Martin Huber, M.D.
N/A $ 625,000
N/A
Anna Protopapas
$ 605,000 $ 650,000 7.4%
Brian DeSchuytner
$ 421,303 $ 444,475 5.5%
Mohan Bala, Ph.D.
$ 410,000 $ 430,500 5.0%
Alejandra Carvajal
$ 414,000 $ 430,560 4.0%
Timothy B. Lowinger, Ph.D.
$ 450,036 $ 470,063 4.5%
Arvin Yang, M.D.
$ 527,850 $ 546,325 3.5%
Annual Performance-Based Cash Compensation
The purpose of our annual cash incentive program is to provide short-term variable cash compensation to incentivize and reward our executive officers to achieve or exceed our annual corporate goals as well as each officer’s annual personal goals. This element of compensation reinforces our pay-for-performance philosophy and incentivizes shorter-term (annual) performance. Each executive officer is eligible for a target bonus determined as a percentage of his or her annual base salary. Our Compensation Committee (or our Board of Directors, in the case of our Chief Executive Officer) determines these target bonus percentages for each executive officer position primarily based on the range of target bonus percentages for similar positions at companies in the peer group. Our Compensation Committee (or our Board of Directors, in the case of our Chief Executive Officer) annually reviews and evaluates each executive officer’s target bonus percentage. Because target bonus percentages by position tend not to be as dynamic as base salary compensation, changes to an executive officer’s target bonus percentage tend to occur less frequently than changes in base salary. The target bonus percentage for each of our named executive officers other than our Chief Executive Officer for 2023 was 40%, and the target bonus percentage for each individual serving as our Chief Executive Officer in 2023 was 60%.
In June 2017, our Board of Directors adopted our 2017 Cash Bonus Plan, or the Bonus Plan. The Bonus Plan governs the determination and payment of annual bonus amounts to certain of our executive officers and key employees. Under the Bonus Plan, each eligible employee is eligible to receive an annual bonus based on the achievement of certain performance criteria established by the Compensation Committee at the beginning of the year.
For annual incentive bonus determinations pursuant to the Bonus Plan, we vary the weighting of personal and corporate goal performance by level within the Company, with greater emphasis placed on corporate performance for our more senior employees. Even among our executive officers, a greater emphasis is placed on corporate performance for our Chief Executive Officer than for our other executive officers, with 100% of the weight attributed to corporate goal performance for our Chief Executive Officer, as compared to 75% of the weight attributed to corporate goal performance and 25% of the weight attributed to individual performance, as subjectively determined by our Compensation Committee in consultation with our Chief Executive Officer, for our other executive officers. We believe this policy aligns our Chief Executive Officer’s performance with that of the Company as a whole and aligns our other executive officers’ performance with the Company as a whole while still incentivizing personal performance, which is generally more aligned with the performance of the functional area that each executive officer leads. In addition, our executive officers have a greater opportunity to significantly impact our corporate goal performance given their positions and responsibilities. With respect to the individual performance weighting for each executive officer other than our Chief Executive Officer, each such executive officer can achieve up to 130%
 
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of such portion of his or her target bonus based on the individual performance ranking achieved in such year. The formula utilized to calculate each executive officer’s, other than our Chief Executive Officer’s, annual incentive bonus is as follows:
(
Annual
Base
Salary
*
Target Bonus
Opportunity
(40%)
)
*
[
(
Corporate
Achievement
Percentage
(0 – 100%)
*
75%
)
+
(
Individual
Performance
Ranking
Multiplier
(0 – 130%)
*
25%
)
]
=
Total
Annual
Bonus
Payout
At the end of the year or early in the following calendar year, our Compensation Committee reviews our performance and the individual performance of each of our executive officers, including our named executive officers, to determine the amount of annual bonus payments to be paid for the year. It is at our Compensation Committee’s discretion to grant individual awards at, below, or above target based on corporate performance and individual performance. In January 2024, our Board of Directors approved the 2023 annual bonus payment to our current Chief Executive Officer based on our Compensation Committee’s recommendation, and our Compensation Committee approved the 2023 annual bonus payments to the other then-serving executive officers. Pursuant to the provisions of the Protopapas Retirement Agreement, we also paid Ms. Protopapas an amount equivalent to the bonus payment she would have received had she been employed as of December 31, 2023, prorated for her actual period of service in 2023. See the immediately following “2023 Corporate Performance Goals” section below for information about how these amounts were calculated for each of Dr. Huber, Ms. Protopapas and our other then-serving named executive officers.
2023 Corporate Performance Goals
In January 2023, our Compensation Committee approved corporate performance goals and weighting for calendar year 2023, and our employees, including our named executive officers (other than our Chief Executive Officer) established individual goals for 2023. Following our announcement of topline data from our UPLIFT Phase 2 clinical trial of UpRi, which data revealed that the trial had failed to achieve its primary endpoint, and after implementing the Restructuring, our management proposed to the Compensation Committee that our corporate goals be revised in order to reflect the Company’s new strategic focus and in order to promote employee engagement by ensuring that our corporate goals established relevant objectives for the Company to pursue and reflected an appropriate workforce and financial resource deployment for the second half of the year. In September 2023, our Compensation Committee determined that the corporate performance goals originally approved for calendar year 2023 would represent goals for the first half of calendar year 2023, or the 1H 2023 Corporate Goals, and re-weighted those performance goals by dividing the original weightings by 2. At the same time, the Compensation Committee approved corporate performance goals and weighting applicable to the second half of calendar year 2023, or the 2H 2023 Corporate Goals. The Compensation Committee further determined that at the end of the year, the Company’s performance in the first half of calendar year 2023 would be assessed against the 1H 2023 Corporate Goals, which achievement would account for 50% of the total annual achievement for 2023, and the Company’s performance in the second half of calendar year 2023 would be assessed against the 2H 2023 Corporate Goals, which achievement would account for 50% of the total annual achievement for 2023. Following approval of the 2H 2023 Corporate Goals, our employees, including our named executive officers (other than our Chief Executive Officer) established revised individual goals for the second half of 2023. The Compensation Committee considered the one-time bifurcation of our annual corporate performance goals to be appropriate in light of the anomalous circumstances we faced in 2023, and for calendar year 2024, the Compensation Committee again established full-year corporate performance goals for our employees, including our executive officers.
The weightings for the 1H 2023 Corporate Goals and 2H 2023 Corporate Goals are as set forth under “Potential Base Points” in the table below. The total number of points, if all specified goals were achieved, added to 100 points, which would yield a payout of 100% of the portion of each named executive officer’s target annual bonus based on corporate performance. We purposely set our goals at challenging levels and believe that achieving a corporate performance percentage exceeding 100% would be based on the Compensation Committee’s determination of exceptional corporate performance. While our Compensation Committee has historically set stretch goals for each year that, if achieved, could contribute a specified number of additional points and yield a maximum potential corporate performance level in excess of 100%,
 
39

 
in light of the significant challenges we faced as an organization in 2023, our Compensation Committee did not believe that consideration of stretch goals was appropriate when determining overall 2023 corporate performance. In light of these potential corporate goal achievement levels and the weighting of corporate and personal goals under our Bonus Plan, in 2023, Dr. Huber, as our Chief Executive Officer serving as of December 31, 2023, was eligible to receive a maximum of 100% of his target bonus, prorated for the portion of the year in which he was employed by us, and each of our other executive officers was eligible to receive a maximum of 107.5% of his or her target bonus.
In January 2024, our Compensation Committee evaluated our achievement of the 1H 2023 Corporate Goals and 2H 2023 Corporate Goals. The Compensation Committee considered whether we had achieved specific objectives underlying each of the foregoing corporate performance goals; management’s self-assessment; and our overall corporate performance in each half of 2023. Based on these considerations, the Compensation Committee determined that we had achieved few of our 1H 2023 Corporate Goals, particularly with respect to our clinical objectives, but had achieved most of our 2H 2023 Corporate Goals. As a result, the Compensation Committee approved 42% (21 points out of 50) achievement of our 1H 2023 Corporate Goals and 96% (48 points out of 50) achievement of our 2H 2023 Corporate Goals, for an overall annual achievement of 69% (69 points out of 100).
Goals — 1H 2023
Potential
Base
Points
Actual
Base
Points
UpRi

Advance UpRi development in preparation for potential future submission of a Biologics License Application, or BLA
15 3

Execute branding and medical affairs preparations for potential commercialization of UpRi, assuming approval of BLA in 2024
3.75 1

Complete enrollment objectives for our UPGRADE-A clinical trial
3.75 2

Progress our UP-NEXT Phase 3 clinical trial
7.5 1
Pipeline & Continued Innovation

Progress dose escalation in Phase 1 clinical trial of XMT-1660
5 5

Progress dose escalation in Phase 1 clinical trial of XMT-2056
5 0

Continue research and development work related to our preclinical product candidate pipeline and platforms, including with respect to our strategic collaborations
2.5 2
Corporate

Maintain a strong balance sheet and execute new business development transactions that meet our strategic objectives for our platforms and product candidates
5 5

Maintain and continue to build a strong organization
2.5 2
1H 2023 Subtotal 50 21
Goals — 2H 2023
Potential
Base
Points
Actual
Base
Points
Clinical Development

Wind-down UpRi program
5 5

Progress dose escalation in Phase 1 clinical trial of XMT-1660
20 18

Complete activities necessary to prepare to resume Phase 1 clinical trial
7.5 7.5
Pipeline & Continued Innovation

Continue research and development work related to our preclinical product candidate pipeline and platforms, including with respect to our strategic collaborations
5 5
Corporate

Maintain a strong balance sheet and execute new business development transactions that meet our strategic objectives for our platforms and product candidates
7.5 7.5

Maintain strong culture and minimize voluntary attrition
5 5
2H 2023 Subtotal 50 48
2023 Total 100 69
 
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After calculating potential bonuses payable to our then-serving executive officers (other than our Chief Executive Officer) pursuant to our Bonus Plan based on a 69% overall achievement score, the Compensation Committee elected to exercise its downward discretion with respect to bonuses payable under our Bonus Plan by capping overall effective corporate achievement for our executive officers (other than Dr. Huber, whose bonus is discussed below) at 50%. The Compensation Committee intended for this cap to reflect the setbacks encountered by the Company, under the leadership of our executive officers, in the first half of 2023, and to more closely align executive pay with Company performance for the year. Our Compensation Committee also recommended, and our Board of Directors agreed, that the bonus payment payable to Ms. Protopapas pursuant to the Protopapas Retirement Agreement would also be subject to the 50% corporate achievement cap, aligning Ms. Protopapas’ pay with that of the other executive officers who served during her tenure as Chief Executive Officer.
With respect to the potential bonus payable to Dr. Huber, who commenced serving as our Chief Executive Officer in September 2023, our Compensation Committee recommended, and our Board of Directors agreed, that his bonus, which is calculated based solely on corporate performance, should be calculated based on the Company’s 96% performance against only the 2H 2023 Corporate Goals since Dr. Huber served as our Chief Executive Officer only during the second half of 2023.
2023 Individual Performance
The performance for the 2023 fiscal year of each of our then-serving executive officers, other than our Chief Executive Officer, was reviewed by our Compensation Committee in consultation with our Chief Executive Officer, and each executive’s performance was then subjectively assessed. Our Compensation Committee, after consulting with our Chief Executive Officer, assigned an individual achievement percentage for each such executive. For 2023, the target annual bonus for each named executive officer, the corporate and individual goal weighting and achievement, and the amount paid to those individuals is as set forth in the table below.
Based on the above, the Compensation Committee (or, in the case of our current and former Chief Executive Officers, our Board of Directors) awarded 2023 bonuses, paid in cash during the first quarter of 2024, to our then-serving named executive officers, as well as to Ms. Protopapas pursuant to the Protopapas Retirement Agreement, as follows:
Name and Position
Target Bonus
(% of Base
Salary)
Effective
Corporate
Goal
Achievement
Weight of
Corporate
Goal
Achievement
Individual
Performance
Achievement
Weight of
Individual
Performance
Achievement
Bonus
Amount
Paid
($)
Bonus
Amount Paid
(% of Target
Bonus)
Martin Huber, M.D., President and Chief Executive Officer
60% 96% 100% $ 110,466(1) 96%
Anna Protopapas, former President and
Chief Executive Officer
60% 50% 100% $ 135,164(1) 50%
Brian DeSchuytner, Senior Vice
President, Chief Operating Officer and
Chief Financial Officer
40% 50% 75% 110% 25% $ 115,564 65%
Mohan Bala, Senior Vice President, Chief Development Officer
40% 50% 75% 110% 25% $ 111,930 65%
Alejandra Carvajal, Senior Vice President, Chief Legal Officer
40% 50% 75% 130% 25% $ 120,557 70%
Timothy B. Lowinger, Ph.D., Senior Vice
President, Chief Science & Technology
Officer
40% 50% 75% 85% 25% $ 110,465 59%
(1)
Reflects proration for partial-year service.
Long-Term Equity Incentive Compensation
Long-term equity incentive compensation is the largest portion of each executive’s overall compensation and is variable and at-risk. Because the drug development process is lengthy, generally taking many years and requiring long-term investments that have a substantial risk of failure, we believe it is appropriate that
 
41

 
this element of compensation represents the largest potential portion of each executive’s overall compensation to focus our executive officers on long-term success. This element of compensation is generally comprised of equity awards that we grant in connection with the start of each executive officer’s employment and annual grants, typically in January of each calendar year, of long-term equity incentive equity awards. These equity awards generally vest over several years to focus our executives on our success over a multi-year period and promote the retention of our executive officers. Our Compensation Committee may also grant, or recommend that the Board of Directors grant, additional equity awards to our executive officers from time to time, including as discussed below under “September 2023 Equity Awards,” though we have not historically relied on such “off-cycle” awards as a meaningful component of our overall executive compensation philosophy.
We also design our long-term equity awards to remain competitive in the recruitment and retention of executive officers and other employees. We generally target both our annual awards and new hire awards of long-term equity incentive compensation to be at approximately the median of our peer group, when considering the size of awards on an option-equivalent, percentage-of-shares-outstanding basis. Like short-term incentive compensation, no executive officer is guaranteed to receive any equity awards or awards of a certain value.
Since 2020, we have used a combination of stock options and RSUs as the primary equity award instruments for long-term equity incentive compensation. This practice is consistent with the long-term equity incentive compensation practices of our peer group. Stock option awards provide our executive officers with the right to purchase shares of our common stock at a fixed exercise price equal to the closing price of our common stock on the date of grant. Each RSU represents a contingent right to receive one share of our common stock. Stock options and RSUs typically vest over four years subject to the executive’s continued service with us; awards to newly hired executive officers typically have an initial one-year cliff vesting feature, while annual awards do not. We believe these features provide an appropriate long-term equity incentive and reward the option holder only to the extent that our stock price increases and stockholder value increases. As a company that relies heavily on the use of stock options and RSUs to align the interests of employees, including our named executive officers, with the interests of stockholders, we do not believe that the accounting grant date fair value should be the primary determinant of award size. Stock prices of non-commercial drug development companies are highly volatile and influenced by factors outside of our control. As a result, value-based determinations can be difficult because employees may be rewarded with more shares due to decreases in our stock price or penalized with fewer shares due to increases in our stock price even over short time periods.
As with the other elements of compensation, our Compensation Committee, with the assistance of Pearl Meyer, reviews preliminary market-based recommendations for annual equity awards and awards made in connection with an executive’s hire or promotion based on our peer group and survey data. Our Compensation Committee then considers recommendations from our Chief Executive Officer for equity awards for executive officers (other than herself or himself, as applicable) and approves equity awards for all of our executive officers, with the exception of our Chief Executive Officer, whose grant is approved by our Board of Directors upon the recommendation of our Compensation Committee. In evaluating the target size of equity grant awards for executive officers, our Compensation Committee takes into consideration market and peer group data regarding long-term incentive compensation to ensure our grants are competitive. We balance this with a consideration of the aggregate number of share-based awards we expect to grant during the calendar year as compared to the total number of shares outstanding, which is referred to as our burn rate, and the number of share-based incentive awards outstanding and available as compared to the total number of shares outstanding, which is referred to as our overhang. Our Compensation Committee also takes into consideration each executive officer’s performance and contributions to the company, the recommendations of our Chief Executive Officer (except with respect to herself or himself, as applicable) and the amount of the executive officer’s owned, vested and unvested equity holdings.
January 2023 Annual Equity Awards
For annual equity awards to our then-serving executives in 2023, our Compensation Committee determined it was again appropriate to target approximately 75% of the value of long-term equity incentive compensation in the form of stock options and the remaining approximately 25% of the value in the form
 
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of RSUs. The Compensation Committee believed that this equity mix helps to ensure that opportunities to recognize additional financial benefits remains tied to stock performance (through stock options) and to promote retention (via RSUs that vest over time to deliver comparable value to stock options as of the grant date while using fewer authorized shares).
After considering the factors described above, in January 2023, our Compensation Committee approved annual grants to our named executive officers (other than our then-serving Chief Executive Officer) of the stock options and RSUs shown in the table below, and our Board of Directors approved the annual grant shown below to Ms. Protopapas, who was then serving as our Chief Executive Officer. Dr. Huber was not eligible for an annual grant in January 2023 as he was not then serving as an executive officer.
Name
Stock Options
(#)(1)
RSUs
(#)(2)
Anna Protopapas
562,500 125,000
Brian DeSchuytner
180,000 40,000
Mohan Bala, Ph.D.
157,500 35,000
Alejandra Carvajal
161,250 35,833
Timothy B. Lowinger, Ph.D.
168,750 37,500
Arvin Yang, M.D.
217,500 48,333
(1)
Each of these stock option awards has an exercise price of $6.06 and vests in equal quarterly installments over the first four years after the vesting commencement date, January 13, 2023, subject to continued employment through the applicable vesting date.
(2)
These RSUs vest over four years in four equal annual installments beginning on the first anniversary of the grant date, subject to continued employment through the applicable vesting date.
September 2023 Equity Awards
In connection with the Restructuring, in July 2023, our Compensation Committee offered time-vesting, service-contingent cash and, in same cases, equity, retention awards to our retained employees other than our Senior Officers in order to promote and incentivize such employees’ continued service to Mersana over the medium-term horizon as we refocused our strategy and devoted our energy to pursuing new objectives. In September 2023, in connection with the announcement of Ms. Protopapas’ retirement, Dr. Huber’s appointment as President and Chief Executive Officer, and the departure of several members of senior management, including Dr. Yang, our Compensation Committee determined that it was also appropriate to grant one-time retention awards to the remaining members of senior management, including our then-serving named executive officers other than Dr. Yang, with the joint goals of mitigating the risk of voluntary attrition at the executive level over the medium-term horizon while conserving our cash resources and continuing to align the interests of our executives with those of our stockholders. Consequently, in September 2023, the Compensation Committee approved retention RSU awards to Drs. Bala and Lowinger, Ms. Carvajal and Mr. DeSchuytner as shown in the table below. Pursuant to their terms, these retention awards will be forfeited in full in the event the applicable named executive officer voluntarily terminates his or her employment with us prior to October 1, 2024. Also in September 2023, in connection with commencement of his employment as our President and Chief Executive Officer effective September 11, 2023, our Board of Directors approved new hire equity grants to Dr. Huber of the stock options and RSUs shown in the table below.
Name
Stock Options
(#)
RSUs
(#)
Martin Huber, M.D.
1,000,000(1) 667,000(2)
Brian DeSchuytner
50,000(3)
Mohan Bala, Ph.D.
50,000(3)
Alejandra Carvajal
50,000(3)
Timothy B. Lowinger, Ph.D.
50,000(3)
(1)
This stock option award has an exercise price of $1.32 per share and vests as to 25% of the award on
 
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September 11, 2024 and in 12 equal quarterly installments thereafter, subject to continued employment through the applicable vesting date.
(2)
These RSUs vest over four years in four equal annual installments beginning on the first anniversary of the grant date, September 11, 2023, subject to continued employment through the applicable vesting date.
(3)
These RSUs vest in full on October 1, 2024, subject to continued employment through such vesting date.
Other Equity Awards
Prior to his appointment as our President and Chief Executive Officer in September 2023, Dr. Huber was eligible for and received equity awards for his service as a non-employee director pursuant to our Amended & Restated Non-Employee Director Compensation Policy, described more fully in the section titled “Non-Employee Director Compensation” above. Similarly, following her retirement, Ms. Protopapas received an equity award for her service as a non-employee director as described below in the section titled “Executive Compensation — Employment Arrangements — Retirement and Separation Agreement with Ms. Protopapas.”
Benefits Programs and Perquisites
Our executive officers, including our named executive officers, are eligible to participate in all of our employee benefit plans, including our medical, dental, vision, group life and disability insurance plans, on the same basis as our other salaried employees. We pay the premiums for term life insurance and disability insurance for all of our employees, including our named executive officers. We do not maintain any defined benefit pension or non-qualified deferred compensation plans.
All of our full-time employees in the United States, including our named executive officers, are eligible to participate in our 401(k) plan, which is a retirement savings defined contribution plan established in accordance with Section 401(a) of the Internal Revenue Code of 1986, as amended, or the Code. Pursuant to our 401(k) plan, employees may elect to defer their eligible compensation on a pre-tax basis, up to the statutorily prescribed annual limits and to have the amount of this deferral contributed to our 401(k) plan. The 401(k) plan also permits us to make discretionary employer contributions and matching contributions, subject to IRS limits. For 2023, we matched one hundred percent (100%) of the first four percent (4%) of the eligible compensation contributed by participating employees, up to seven thousand dollars ($7,000), which matching contributions are fully vested upon contribution.
We do not provide any other perquisites or personal benefits to our named executive officers, and we do not provide any tax gross-up payments to our named executive officers.
Other Features of our Executive Compensation Program
Executive Employment Agreements
Each of our named executive officers is party to a letter agreement with us that sets forth the terms and conditions of the executive’s employment with us. Each letter agreement provides for at-will employment with us. Each letter agreement sets forth the executive’s base salary, which is eligible for potential discretionary merit increases, and target annual bonus (expressed as a percentage of base salary). Each of our named executive officers is also party to our standard nondisclosure, noncompetition and assignment of intellectual property agreement. Pursuant to their letter agreements, each of the named executive officers is also entitled to certain compensation and benefits upon termination of his or her employment in certain circumstances, including following a change in control. We believe that these severance benefits are an important element of our executive compensation and retention program, particularly in the context of a corporate transaction where provision of such benefits eliminates, or at least reduces, the potential reluctance of our executive officers to diligently consider and pursue potential transactions that may be in the best interests of our stockholders. We also believe that our severance arrangements with our named executive officers are consistent with compensation arrangements provided in a competitive market for executive talent and that the events triggering payment represent appropriate hurdles for the severance benefits. The
 
44

 
severance benefits provided under these letter agreements are described under “— Payments on Termination of Employment or Change in Control Benefits” below.
Other Compensation Policies/Assessments
Risk Assessment
Our Compensation Committee recognizes that providing certain types of compensation incentives may inadvertently motivate individuals to act in ways that could be detrimental to the Company in order to maximize personal compensation. To minimize such risk, our Compensation Committee reviews at least annually the overall structure and components of our compensation program and, with respect to our executive officers, the levels of compensation under such program. Our Compensation Committee has reviewed our compensation program and has determined that it does not encourage inappropriate actions or risk taking and is not reasonably likely to have a material adverse effect on our business. In addition, we do not believe that the mix and design of the components of our executive compensation program encourage our executive officers to assume excessive risks. We believe that our compensation programs, current business process and planning cycle foster the behaviors and controls that would mitigate the potential for adverse risk, including the following:

base salaries that are consistent with our executive officers’ responsibilities and market data and that are established to ensure that our executive officers would not be motivated to take excessive risks to achieve a reasonable level of financial security;

corporate objectives for our annual bonus program for our executive officers that are consistent with our annual operating and strategic plans, that are designed to achieve the proper risk/reward balance, and that should not require excessive risk taking to achieve;

the mix between fixed and variable, annual and long-term and cash and equity compensation is designed to encourage strategies and actions that balance our short-term and long-term best interests; and

stock option and RSU awards vest over a period of time, which we believe encourages executives to take a long-term view of our business.
Clawback Policy
As a public company, if we are required to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws as a result of misconduct, the Chief Executive Officer and Chief Financial Officer may be legally required, in accordance with the provisions of Section 304 of the Sarbanes-Oxley Act of 2002, to reimburse Mersana for any bonus or other incentive-based or equity-based compensation they received.
In addition, in September 2022, in part in response to feedback from our stockholders and others, we adopted a clawback policy applicable to our executive officers, our principal accounting officer and such other employees or classes of employees as our Board of Directors may determine from time to time, or the Covered Persons. Effective October 2, 2023, we amended and restated our clawback policy to comply with Nasdaq Listing Rule 5608. The Mersana Therapeutics, Inc. Amended and Restated Clawback Policy, or the Amended and Restated Clawback Policy, covers cash and equity incentive-based compensation paid to such Covered Persons that is granted, earned, or vested based wholly or in part upon the attainment of a financial reporting measure and provides that if (i) we are required to prepare an accounting restatement for periods that end after the effective date of the policy and (ii) a current or former Covered Person received incentive-based compensation based on erroneous data, we will attempt to recover from such Covered Person any excess incentive-based compensation received by that Covered Person during the three-year period preceding the date on which we are required to prepare the restatement. Additionally, the Amended and Restated Clawback Policy provides that if (i) we are required to prepare an accounting restatement for periods that end after the effective date of the policy, (ii) a current or former Covered Person received incentive-based compensation based on erroneous data, and (iii) our Compensation Committee determines that such Covered Person’s acts or omission caused or partially caused the circumstances requiring the restatement, and such Covered Person’s acts or omissions involved either intentional misconduct or an intentional violation
 
45

 
of our rules or any applicable legal or regulatory requirement or fraud in the course of such Covered Person’s employment or other engagement with us, our Compensation Committee may seek to recover from any current or former Covered Person up to all of the incentive-based compensation received by such Covered Person during the three-year period preceding the date on which we are required to prepare the restatement.
Stock Ownership Guidelines
In September 2022, in part in response to feedback from our stockholders and others, we adopted stock ownership guidelines applicable to our non-employee directors and our executive officers intended to further align the interests of our leadership with those of our stockholders. The stock ownership guidelines require that our Chief Executive Officer must hold equity worth at least three times his or her base salary, that each of our other executive officers must hold equity worth at least one times his or her base salary, and each of our non-employee directors must hold equity worth at least three times of the cash portion of the base annual retainer for regular service on the Board of Directors. The following forms of equity will count toward the ownership guidelines: shares owned outright, vested and unvested restricted stock units and any other vested grants or account balances under share-based company compensation plans. Unexercised, vested stock options and unvested stock options will not count toward the ownership guidelines. Compliance with the guidelines will be determined as of June 30 each year, and newly promoted, appointed or elected persons have five years to achieve compliance with the guidelines. Our executive officers and non-employee directors who were serving at the time we adopted the stock ownership guidelines are expected to accumulate the applicable stock ownership level by June 30, 2028, which also reflects a five-year period following adoption to achieve compliance with the guidelines. Dr. Huber is also expected to accumulate the applicable stock ownership level by June 30, 2028, which is the annual determination date occurring in the calendar year of the fifth anniversary of his commencement of employment as an executive officer.
Insider Trading Policy & Hedging and Pledging Restrictions
Our insider trading policy prohibits our employees, including our named executive officers, as well as our directors and certain family members, associated individuals and controlled entities of our employees and our directors, from engaging in short sales, transactions in put or call options, hedging transactions or other inherently speculative transactions with respect to our securities at any time. We may also determine that other persons should be subject to the policy, such as contractors or consultants who have access to material nonpublic information about Mersana. In addition, persons subject to the policy are prohibited from holding Mersana securities in a margin account or otherwise pledging our securities as collateral for a loan. Our window period policy provides that certain of our employees, including our executive officers, and our non-employee directors are required to limit their transactions in the Company’s stock to defined time periods following public dissemination of quarterly and annual financial results. All of our employees, including our executive officers, and our non-employee directors are required to seek pre-clearance from our Chief Legal Officer or her designee prior to engaging in transactions in the Company’s stock.
Accounting and Tax Considerations
Under ASC 718, the Company is required to estimate and record an expense for each award of equity compensation over the vesting period of the award. We record share-based compensation expense on an ongoing basis according to ASC 718.
Report of the Compensation Committee of the Board of Directors
The Compensation Committee has reviewed and discussed the Compensation Discussion and Analysis required by Item 402(b) of Regulation S-K with our management. Based on this review and discussion, the Compensation Committee recommended to our Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statement.
This report of the Compensation Committee is not “soliciting material,” shall not be deemed “filed” with the Securities and Exchange Commission and shall not be incorporated by reference by any general statement incorporating by reference this Proxy Statement into any filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date
 
46

 
hereof and irrespective of any general incorporation language in any such filing, except to the extent that we specifically incorporate this information by reference, and shall not otherwise be deemed filed under such acts.
The foregoing report has been furnished by the Compensation Committee.
Members of the Compensation Committee of Mersana Therapeutics, Inc.
David Mott, Chair
Allene M. Diaz
Kristen M. Hege, M.D.
 
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2023 Summary Compensation Table
The following table sets forth the compensation awarded to, earned by, or paid to our named executive officers in respect of their service to the Company for the fiscal years ended December 31, 2023, and, if applicable, December 31, 2022 and December 31, 2021.
Name and Principal Position
Year
Salary
($)
Stock
Awards
($)(1)
Option
Awards
($)(2)
Non-Equity
Incentive
Plan
Compensation
($)(3)
All
Other
Compensation
($)(4)
Total
($)
Martin Huber, M.D.(5)
President and Chief Executive Officer
2023 194,311 880,440 1,133,300 110,466 282,733(6) 2,601,249
Anna Protopapas(7)
Former President and Chief Executive Officer
2023 448,333 757,500 3,019,207 224,969(8) 4,450,009
2022 605,000 420,760 1,377,747 435,600 7,000 2,846,107
2021 569,250 1,792,650 5,632,504 276,086 7,000 8,277,490
Brian DeSchuytner
Senior Vice President, Chief Operating Officer and Chief Financial Officer
2023 444,475 299,400 871,776 115,564 7,000 1,738,215
2022 421,303 157,000 514,170 198,012 7,000 1,297,485
2021 405,099 527,250 1,656,619 158,394 7,000 2,754,362
Mohan Bala, Ph.D.(9)
Senior Vice President, Chief Development Officer
2023 430,500 269,100 762,804 111,930 7,000 1,581,334
Alejandra Carvajal(10)
Senior Vice President, Chief Legal Officer
2023 430,560 274,148 780,966 120,557 7,000 1,613,231
2022 414,000 62,800 205,668 192,510 874,978
2021 274,359 449,970 1,346,209 107,712 2,178,250
Timothy B. Lowinger, Ph.D.
Senior Vice President, Chief Science and
Technology Officer
2023 470,063 284,250 817,290 110,465 7,000 1,689,068
2022 450,036 120,369 394,197 209,267 7,000 1,180,869
2021 423,563 615,132 1,932,722 167,731 7,000 3,146,148
Arvin Yang, M.D.(11)
Former Senior Vice President, Chief Medical Officer
2023 409,744 292,898 1,053,396 156,314(12) 1,912,352
2022 527,850 177,931 582,726 245,450 7,000 1,540,957
2021 510,000 201,960 157,000(13) 868,960
(1)
Amounts represent the aggregate grant date fair value of RSU awards granted to our named executive officers in 2021, 2022 and 2023, as applicable, computed in accordance ASC Topic 718, and excluding the effect of estimated forfeitures related to service-based vesting conditions. The assumptions used in the valuation of these RSU awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report.
(2)
Except as otherwise noted in this footnote 2, amounts represent the aggregate grant date fair value of stock option awards granted to our named executive officers in 2021, 2022 and 2023, as applicable, computed in accordance with ASC Topic 718 and excluding the effect of estimated forfeitures related to service-based vesting conditions. The assumptions used in the valuation of these option awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report. The amount for Ms. Protopapas reflects the sum of (a) the original grant date fair value of her January 2023 option award, which equals $2,724,300, plus (b) $294,907 of incremental fair value recognized in connection with the modification, pursuant to the Protopapas Retirement Agreement, of Ms. Protopapas’ outstanding, fully vested option awards granted under the Mersana Therapeutics, Inc. 2007 Stock Incentive Plan, or the 2007 Stock Incentive Plan, in order to permit such options to remain exercisable until the earlier of the end of the applicable term of the option and three months after Ms. Protopapas ceases to be a member of our Board of Directors.
(3)
Unless otherwise stated, amounts represent the annual cash bonuses paid to our named executive officers for 2021, 2022 and 2023, as applicable, in accordance with our Bonus Plan.
(4)
Unless otherwise stated, amounts represent 401(k) matching contributions for 2021, 2022 and 2023, as applicable.
(5)
Dr. Huber served as a non-employee director of the Company through September 10, 2023, and he was appointed our President and Chief Executive Officer on September 11, 2023, at which point he remained on our Board of Directors but ceased being a non-employee director. For purposes of this table, the amount shown in the salary column includes Dr. Huber’s annual base salary for 2023 ($625,000), prorated from his employment commencement date of September 11, 2023. The non-equity incentive
 
48

 
plan compensation column reflects the annual cash bonus amount actually earned by Dr. Huber for 2023 after commencing employment with us; see the section titled “Compensation Discussion and Analysis — Elements of Our Executive Compensation Program — Annual Performance-Based Cash Compensation — 2023 Corporate Performance Goals” above.
(6)
Consists of (a) $32,808 in cash fees earned for 2023 service as a non-employee director through September 10, 2023, which cash fees earned Dr. Huber elected to receive in the form of options to purchase an aggregate of 16,954 shares of common stock granted on April 3, 2023, July 3, 2023 and October 2, 2023, (b) an award of options to purchase 18,355 shares of common stock with a grant date fair value of $124,930 granted to Dr. Huber on June 8, 2023 pursuant to our NED Compensation Policy and (c) an award of 14,467 RSUs with a grant date fair value of $124,955 granted to Dr. Huber on June 8, 2023 pursuant to our NED Compensation Policy. All of these RSUs were subsequently rescinded in connection with his appointment as our President and Chief Executive Officer and the grant of additional equity awards in accordance with his employment offer letter in order to comply with the per-participant award limitations specified in our 2017 Stock Incentive Plan.
(7)
Ms. Protopapas served as our President and Chief Executive Officer and a director of the Company until her retirement from employment on September 10, 2023, and she continued her service to the Company as a non-employee director thereafter. For purposes of this table, the amount shown in the salary column includes Ms. Protopapas’s annual base salary for 2023 ($650,000), prorated for her service until September 10, 2023.
(8)
Consists of (a) 7,000 in 401(k) matching contributions, (b) $12,192 in cash fees paid for 2023 service as a non-employee director from September 11, 2023 to December 31, 2023, (c) an award of 16,643 RSUs with a grant date fair value of $21,969 granted to Ms. Protopapas on September 11, 2023 pursuant to the Protopapas Retirement Agreement in connection with her service as a non-employee director from and after September 11, 2023, (d) an award of options to purchase 16,643 shares of common stock with a grant date fair value of $18,645 granted to Ms. Protopapas on September 11, 2023 pursuant to the Protopapas Retirement Agreement in connection with her service as a non-employee director from and after September 11, 2023, (e) $29,999 in accrued vacation and (f) $135,164 paid to Ms. Protopapas in connection with our obligation under the Protopapas Retirement Agreement to pay Ms. Protopapas an amount equivalent to the bonus payment she would have received had she been employed as of December 31, 2023, prorated for her actual period of service in 2023; see the section entitled “Executive Compensation — Compensation Discussion and Analysis — Annual Performance-Based Cash Compensation — 2023 Corporate Performance Goals” above.
(9)
Dr. Bala was appointed our Senior Vice President, Chief Development Officer and designated as an executive officer on September 5, 2023.
(10)
Ms. Carvajal’s employment with us began on April 26, 2021. The 2021 salary and bonus amounts reported in the table represent the amounts actually earned by her for 2021 after commencing employment with us.
(11)
Dr. Yang’s employment with us began on November 30, 2020 and ended on September 30, 2023. The 2023 salary amount reported in the table represents the amount actually earned by him in 2023. Dr. Yang was not eligible to receive an annual equity award in 2021 and was not eligible to receive a cash bonus award for 2023.
(12)
Includes $136,581 in severance payments and $12,733 in accrued vacation paid to Dr. Yang. Upon his termination of employment and subject to his continued compliance with the terms of his post-employment obligations to us, Dr. Yang was entitled to aggregate severance payments of $409,744, payable in installments in accordance with the Company’s regular payroll practices, of which $136,581 was paid through December 31, 2023.
(13)
Includes $150,000 paid to Dr. Yang in connection with his relocation to the Boston metropolitan area following his commencement of employment by us in November 2020.
Pay Ratio Disclosure
As required by Section 953(b) of the Dodd-Frank Act and Item 402(u) of Regulation S-K, we are required to disclose the ratio of the annual total compensation of the individual identified as our paid
 
49

 
median employee to the annual total compensation of our principal executive officer, our Chief Executive Officer. The paragraphs that follow describe our methodology and the resulting pay ratio.
Annual Total Compensation of Median Employee
We identified our median employee using our employee population as of December 31, 2023 by (i) aggregating for each applicable employee (A) annual base salary as of December 31, 2023 for salaried employees (or hourly rate multiplied by expected annual work schedule, for hourly employees), (B) actual bonus for 2023 and (C) the grant date fair value of any annual or new hire equity awards granted during the fiscal year ended December 31, 2023 and (ii) ranking this aggregated compensation measure for our employees (excluding Dr. Huber, who was serving as our Chief Executive Officer on December 31, 2023) from highest to lowest. Salaries or wages for those employees hired during 2023 were annualized. Once the median employee was identified, we calculated the median employee’s annual total compensation in accordance with the rules applicable to the Summary Compensation Table.
The total compensation for 2023 for our median employee, identified as discussed above, was $315,949.
Annual Total Compensation of Chief Executive Officer
We had two individuals in the role of chief executive officer during 2023. Ms. Protopapas served as chief executive officer from January 1, 2023 through September 10, 2023; Dr. Huber served as chief executive officer from September 11, 2023 through December 31, 2023.
For purposes of the pay ratio disclosure, we have annualized the compensation of Dr. Huber, who was serving as chief executive officer on December 31, 2023, to reflect a full year of his compensation. Accordingly, we have:
(i)
annualized his base salary, resulting in a base salary of $625,000, and
(ii)
annualized the amount of his non-equity incentive plan compensation by multiplying his annualized base salary by his 2023 target bonus percentage of 60% to obtain his target bonus amount, and multiplying that target bonus amount by our percentage corporate achievement for 2023, or 69%, resulting in non-equity incentive plan compensation of $258,750.
This resulted in total annual compensation of $3,180,223 for Dr. Huber. Therefore, our pay ratio is approximately 10.1 to 1.
The pay ratio reported above is a reasonable estimate calculated in a manner consistent with SEC rules based on our internal records and the methodology described above. The SEC rules for identifying the median compensated employee and calculating the pay ratio based on that employee’s annual total compensation allow companies to adopt a variety of methodologies, to apply certain exclusions, and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices. Therefore, the pay ratio reported by other companies may not be comparable to the pay ratio reported above, as other companies have different employee populations and compensation practices and may utilize different methodologies, exclusions, estimates and assumptions in calculating their own pay ratios.
Pay Versus Performance
In accordance with rules adopted by the SEC pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following tables and related disclosures regarding (i) the “total compensation” of our principal executive officer, or the PEO, and our other named executive officers, or the Non-PEO NEOs, (ii) the “Compensation Actually Paid,” or CAP, to our PEO and non-PEO NEOs, (iii) certain performance measures for the fiscal years listed below and (iv) the relationship of CAP to those performance measures. The section entitled “Compensation Discussion & Analysis” above describes the compensation setting process for our executive officers, which is done independently from the disclosure requirements.
Pay Versus Performance Table
The following table provides the information required for each individual serving as our PEO and our non-PEO NEOs for each of the fiscal years ended December 31, 2023, December 31, 2022, December 31,
 
50

 
2021 and December 31, 2020, along with the required financial information required for each fiscal year. We are a pre-commercial biotechnology company and as such, we did not derive any revenue from the sales of any products during the periods presented and have not reached the stage of profitability. Consequently, we have not historically focused on net income (loss) as a performance measure for our executive compensation program. Additionally, our Compensation Committee does not utilize total stockholder return, or TSR, in our executive compensation program. However, as discussed above, we do utilize several other operational corporate performance measures to align executive compensation with our performance. As described in more detail above in the section titled “Compensation Discussion and Analysis — Elements of Our Executive Compensation Program — Annual Performance-Based Cash Compensation — 2023 Corporate Performance Goals,” part of the compensation our PEO and Non-PEO NEOs are eligible to receive consists of annual performance-based cash bonuses that are designed to provide appropriate short-term incentives to our executives to achieve defined annual corporate goals, as well as equity awards designed to provide long-term incentives to our executives to maximize long-term value for our stockholders and to encourage our executive officers to continue in our employment for the long-term.
Year-end value
of $100 invested
on 12/31/2019 in:
Year
Summary
Compensation
Table
Total for
the First
PEO(1)
($)
Summary
Compensation
Table
Total
for the
Second
PEO(2)
($)
Compensation
Actually
Paid to
the First
PEO(1)(3)(4)
($)
Compensation
Actually
Paid to
the Second
PEO(2)(3)(4)
($)
Average
Summary
Compensation
Table
Total for
Non-PEO
NEOs(5)
($)
Average
Compensation
Actually
Paid to
Non-PEO
NEOs(3)(4)(5)
($)
MRSN
Total
Shareholder
Return
($)
Peer
Group
Total
Shareholder
Return(6)
($)
Net Loss
(in millions)
($)
2023
2,601,249 4,450,009 4,255,366 (353,115) 1,706,840 495,789 40.49 118.87 (171.7)
2022
N/A 2,846,107 N/A 2,407,467 1,223,572 1,079,403 102.27 113.65 (204.2)
2021
N/A 8,277,490 N/A (6,779,152) 2,409,043 (1,407,347) 108.55 126.45 (170.1)
2020
N/A 2,537,911 N/A 16,408,361 2,005,448 6,137,850 464.40 126.42 (88.0)
(1)
Martin Huber, M.D., or the First PEO, was appointed our President and Chief Executive Officer on September 11, 2023.
(2)
Anna Protopapas, or the Second PEO, served as our President and Chief Executive Officer until September 10, 2023 and was the PEO 2022, 2021 and 2020.
(3)
The following tables describe deductions from, and additions to, total compensation in the Summary Compensation Table by year to calculate CAP. The Summary Compensation Table Amounts and CAP do not reflect the actual amount of compensation earned by or paid to our executives during the applicable years but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act.
2023
2022
2021
2020
First
PEO
($)
Second
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
Total Compensation from Summary Compensation Table
2,601,249 4,450,009 1,706,840 2,846,107 1,223,572 8,277,490 2,409,043 2,537,911 2,005,448
Adjustments for Equity Awards
Adjustment for grant date values in the Summary Compensation Table
(2,013,740) (3,776,707) (1,141,206) (1,798,507) (553,715) (7,425,154) (1,981,419) (1,656,411) (1,550,241)
Year-end fair value of unvested awards granted in the current year
3,533,476 510,197 347,755 1,441,729 443,870 1,538,348 430,621 7,965,820 3,341,447
Year-over-year difference of year-end fair values for unvested awards granted in prior years
(643,200) (220,779) (196,374) (58,449) (6,105,508) (1,108,788) 5,655,169 1,717,834
Fair values at vest date for awards granted and vested in current year
31,811 229,104 54,374 226,105 69,615 567,422 99,283 822,260 215,235
 
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2023
2022
2021
2020
First
PEO
($)
Second
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
PEO
($)
Average
Non-PEO
NEOs
($)
Difference in fair values between prior year-end fair values and vest date fair values for awards granted in prior years
102,570 (281,491) (84,633) (111,593) (45,490) (3,631,751) (661,387) 1,083,613 408,127
Forfeitures during current year equal to prior year-end fair value
(841,027) (166,562) (594,699)
Total Adjustments for Equity Awards
1,654,117 (4,803,124) (1,211,051) (438,640) (144,169) (15,056,642) (3,816,390) 13,870,451 4,132,402
Compensation Actually Paid (as calculated)
4,255,366 (353,115) 495,789 2,407,467 1,079,403 (6,779,152) (1,407,347) 16,408,361 6,137,850
(4)
Valuation assumptions used to calculate fair values as of vesting dates and fiscal year end did not materially differ from those used to calculate fair values at the time of grant as reflected in the Summary Compensation Table amounts, except that the volatility assumptions used to calculate fair values at date of vesting and fiscal year end are based solely on available volatility data for our common stock. Due to a lack of historical volatility data for our common stock, the expected volatility utilized for the purposes of calculating the grant date fair value was determined based on a blended rate of the historical volatility of our common stock combined with the historical volatility of comparable publicly traded companies. The other assumptions used in the valuation of equity awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report. Compensation Actually Paid for 2020, 2021, and 2022 as reflected in our proxy statement for our 2023 annual meeting of stockholders has been adjusted to incorporate updated volatility assumptions.
(5)
Non-PEO NEOs reflect the average Summary Compensation Table total compensation and average CAP for the following executives by year:

2023: Mohan Bala, Ph.D., Alejandra Carvajal, Brian DeSchuytner, Timothy B. Lowinger, Ph.D. and Arvin Yang, M.D.

2022: Alejandra Carvajal, Brian DeSchuytner, Timothy B. Lowinger, Ph.D. and Arvin Yang, M.D.

2021: Alejandra Carvajal, Brian DeSchuytner, Michael Kaufman, Ph.D., Timothy B. Lowinger, Ph.D. and Tushar Misra, Ph.D.

2020: Brian DeSchuytner, Michael Kaufman, Ph.D., Timothy B. Lowinger, Ph.D. and Arvin Yang, Ph.D.
(6)
The Peer Group Total Shareholder Return set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our 2023 Annual Report. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
 
52

 
Relationships Between Compensation Actually Paid to our NEOs and Performance Measures
The following charts show the relationships over the past four years of the CAP for our PEOs and Non-PEO NEOs as compared to our cumulative TSR and the cumulative NASDAQ Biotechnology Index TSR and as compared to our net loss, as well as the relationship between our cumulative TSR and the cumulative NASDAQ Biotechnology Index TSR.
[MISSING IMAGE: bc_tsr-4c.jpg]
[MISSING IMAGE: bc_netloss-4c.jpg]
 
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Grants of Plan-Based Awards
The following table shows information regarding grants of plan-based awards during the fiscal year ended December 31, 2023 to our named executive officers.
Name
Grant
date
Estimated future
payouts under non-equity
incentive plan awards
All other
stock
awards:
Number of
shares of
stock or
units
(#)
All other
option
awards:
Number of
securities
underlying
options
(#)
Exercise or
base price of
option awards
($/share)
Grant date
fair value
of stock
and option
awards
($)(1)
Threshold
($)
Target
($)
Maximum
($)
Martin Huber, M.D.
(2) 375,000 375,000
4/3/2023(3) 3,375 4.25 10,994
6/8/2023(4) 18,355 8.64 124,930
6/8/2023(5) 14,467 124,995
7/3/2023(3) 4,477 3.42 12,241
9/11/2023(6) 1,000,000 1.32 1,258,230
9/11/2023(7) 667,000 880,440
10/2/2023(3) 9,102 1.26 9,551
Anna Protopapas
(2) 390,000 390,000
1/13/2023(8) 562,500 6.06 2,724,300
1/13/2023(9) 125,000 779,469
9/11/2023(10) 16,643 1.32 18,645
9/11/2023(11) 16,643 21,969
9/11/2023(12) 748,366 1.53 218,523
9/11/2023(12) 158,958 4.10 55,317
9/11/2023(12) 66,666 6.98 21,066
Brian DeSchuytner
(2) 177,790 191,124
1/13/2023(8) 180,000 6.06 871,776
1/13/2023(9) 40,000 242,400
9/5/2023(13) 50,000 57,000
Mohan Bala, Ph.D.
(2) 172,200 185,115
1/13/2023(8) 157,500 6.06 762,804
1/13/2023(9) 35,000 212,100
9/5/2023(13) 50,000 57,000
Alejandra Carvajal
(2) 172,224 185,141
1/13/2023(8) 161,250 6.06 780,966
1/13/2023(9) 35,833 217,148
9/5/2023(13) 50,000 57,000
Timothy B. Lowinger, Ph.D.
(2) 188,025 202,127
1/13/2023(8) 168,750 6.06 817,290
1/13/2023(9) 37,500 227,250
9/5/2023(13) 50,000 57,000
Arvin Yang, M.D.
(2) 218,530 234,920
1/13/2023(8) 217,500 6.06 1,053,396
1/13/2023(9) 48,333 292,898
(1)
Amounts represent the aggregate grant date fair value of RSU and stock option awards granted to our named executive officers and the incremental fair value of the fully vested options originally granted under our 2007 Stock Incentive Plan and held by Ms. Protopapas that were modified during 2023, in each case, computed in accordance with ASC Topic 718 and excluding the effect of estimated forfeitures related to service-based vesting conditions. The assumptions used in the valuation of these awards are set forth in Note 10 to our financial statements included in our 2023 Annual Report.
(2)
Amounts represent the threshold, target and maximum annual cash bonus opportunities for our
 
54

 
named executive officers for 2023 under our Bonus Plan. The amount reported in the threshold column represents the minimum award value that could be received, which is zero. The amount listed in the target column represents each named executive officer’s target annual bonus for 2023. The amount listed in the maximum column represents each named executive officer’s maximum annual cash bonus opportunity for 2023, computed assuming achievement of 100% of the portion of the annual cash bonus payable based on corporate performance (75% of the total cash bonus for named executive officers other than the chief executive officers and 100% for the chief executive officers) and 130% achievement of the portion of the annual cash bonus payable based on individual performance (25% of the total cash bonus for named executive officers other than the chief executive officers and 0% for the chief executive officers) is paid. For Dr. Huber, who was employed for a portion of the year, these amounts represent the annualized amounts; his actual bonus opportunity was prorated based on his employment start date. For Ms. Protopapas, who was employed for a portion of the year, these amounts represent annualized amounts; pursuant to the Protopapas Retirement Agreement, we agreed to pay Ms. Protopapas an amount equivalent to the bonus payment she would have received had she been employed as of December 31, 2023, prorated for her actual period of service in 2023. Dr. Yang’s employment with the Company ended on September 30, 2023, and he was not eligible for an annual bonus for 2023. The actual cash bonus that was paid to each of our named executive officers other than Ms. Protopapas in respect of 2023 performance is reported in the Summary Compensation Table above in the “Non-Equity Incentive Plan Compensation” column, and the amount paid to Ms. Protopapas pursuant to the Protopapas Retirement Agreement in respect of 2023 performance is reported in the Summary Compensation Table above in the “All Other Compensation” column.
(3)
Represents the grant of stock options to Dr. Huber in lieu of the payment of quarterly cash retainer fees for his service as a non-employee director between January 1, 2023 and September 10, 2023. In accordance with our NED Compensation Policy, all such retainer grants are made on the first business day following the conclusion of each calendar quarter and were fully vested as of grant.
(4)
Represents the annual grant of stock options to Dr. Huber in connection with his service as a non-employee director pursuant to our NED Compensation Policy. These stock options will vest in full on June 8, 2024, subject to Dr. Huber’s continued service as a director on such date.
(5)
Represents the annual grant of RSUs to Dr. Huber in connection with his service as a non-employee director pursuant to our NED Compensation Policy. Pursuant to the terms of their grant, these RSUs were to vest in full on June 8, 2024, subject to Dr. Huber’s continued service as a director on such date. However, all of these RSUs were subsequently rescinded in connection with his appointment as our President and Chief Executive Officer and the grant of additional equity awards in accordance with his employment offer letter in order to comply with the per-participant award limitations specified in our 2017 Stock Incentive Plan.
(6)
Represents the grant of stock options to Dr. Huber in connection with his appointment as our President and Chief Executive Officer on September 11, 2023. One quarter of the stock options will vest on the first anniversary of the grant date, and the remainder will vest in equal quarterly installments thereafter over the next three years until fully vested on the fourth anniversary of the grant date, subject to continued employment through the applicable vesting date.
(7)
Represents the grant of RSUs to Dr. Huber in connection with his appointment as our President and Chief Executive Officer on September 11, 2023. The RSUs vest over four years in four equal annual installments beginning on the first anniversary of the grant date, subject to continued employment through the applicable vesting date.
(8)
Represents annual grants of stock options to our named executive officers in 2023. The stock options vest in equal quarterly installments over the first four years after the grant date, subject to continued employment through the applicable vesting date.
(9)
Represents annual grants of RSU awards to our named executive officers in 2023. The RSUs vest over four years in four equal annual installments beginning on the first anniversary of the grant date, subject to continued employment through the applicable vesting date.
(10)
Represents the grant of stock options to Ms. Protopapas pursuant to the Protopapas Retirement Agreement in connection with her service as a non-employee director from and after September 11, 2023. These stock options will vest in full on June 8, 2024, subject to Ms. Protopapas’ continued service as a director on such date.
 
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(11)
Represents the grant of RSUs to Ms. Protopapas pursuant to the Protopapas Retirement Agreement in connection with her service as a non-employee director from and after September 11, 2023. These RSUs will vest in full on June 8, 2024, subject to Ms. Protopapas’ continued service as a director on such date.
(12)
Constitute fully vested stock options for which the post-employment exercise period was extended pursuant to the Protopapas Retirement Agreement to the earlier of the end of the applicable term of the option and three months after Ms. Protopapas ceases to be a member of our Board of Directors.
(13)
Represents the grant of RSUs to Drs. Bala and Lowinger, Ms. Carvajal and Mr. DeSchuytner. These RSUs will vest in full on October 1, 2024, subject to continued employment through such date.
 
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Outstanding Equity Awards at Fiscal Year-End Table
The following table sets forth information concerning the outstanding equity awards held by each of our named executive officers as of December 31, 2023. Dr. Yang’s employment ended on September 30, 2023, and any equity awards outstanding as of the end of his employment were forfeited or expired prior to December 31, 2023.
Option Awards
Stock Awards
Name
Number of
securities
underlying
unexercised
options
exercisable
(#)
Number of
securities
underlying
unexercised
options
unexercisable
(#)
Option
exercise
price
($/share)
Option
expiration
date
Number
of Shares
or Units
of Stock
that Have
Not Vested
(#)
Market
Value of
Shares or
Units of
Stock That
Have Not
Vested(1)
($)
Martin Huber, M.D.
48,096 8.57 4/12/2030
2,490 21.09 1/14/2031
25,050 14.90 6/10/2031
10,185 6.44 1/2/2032
45,000 3.62 6/8/2032
3,375 4.25 4/2/2033
18,355(2) 8.64 6/7/2033
4,477 3.42 7/2/2033
1,000,000(3) 1.32 9/10/2033
9,102 1.26 10/1/2033
667,000(4) 1,547,440
Anna Protopapas
748,366 1.53 5/7/2025
158,958 4.10 8/29/2026
66,666 6.98 3/13/2027
200,000 14.23 2/1/2028
217,500 3.51 1/22/2029
298,828 19,922(5) 6.16 1/14/2030
131,884 169,566(6)(7) 6.28 1/13/2032
105,469 457,031(6)(8) 6.06 1/12/2033
16,643(6)(9) 1.32 9/10/2033
17,708(10) 41,083
42,500(6)(11) 98,600
50,250(6)(12) 116,580
125,000(6)(13) 290,000
16,643(14) 38,612
Brian DeSchuytner
240,000 3.99 7/9/2029
66,796 4,454(5) 6.16 1/14/2030
77,343 35,157(15) 21.09 1/14/2031
49,218 63,282(7) 6.28 1/13/2032
33,750 146,250(8) 6.06 1/12/2033
3,958(10) 9,183
12,500(11) 29,000
18,750(12) 43,500
40,000(13) 92,800
50,000(16) 116,000
Mohan Bala, Ph.D.
56,250 56,250(17) 8.63 10/24/2031
29,531 127,969(8) 6.06 1/12/2033
12,500(18) 29,000
35,000(13) 81,200
50,000(16) 116,000
 
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Option Awards
Stock Awards
Name
Number of
securities
underlying
unexercised
options
exercisable
(#)
Number of
securities
underlying
unexercised
options
unexercisable
(#)
Option
exercise
price
($/share)
Option
expiration
date
Number
of Shares
or Units
of Stock
that Have
Not Vested
(#)
Market
Value of
Shares or
Units of
Stock That
Have Not
Vested(1)
($)
Alejandra Carvajal
70,313 42,187(19) 16.98 4/25/2031
19,688 25,312(7) 6.28 1/13/2032
30,234 131,016(8) 6.06 1/12/2033
7,500(12) 17,400
35,833(13) 83,133
50,000(16) 116,000
Timothy B. Lowinger, Ph.D.


103,868




1.53


6/11/2025
45,854 4.10 8/29/2026
56,884 14.23 2/1/2028
28,128 3.51 1/22/2029
91,291 8,907(5) 6.16 1/14/2030
90,234 41,016(15) 21.09 1/14/2031
37,734 48,516(7) 6.28 1/13/2032
31,641 137,109(8) 6.06 1/12/2033
7,916(10) 18,365
14,583(11) 33,833
14,375(12) 33,350
37,500(13) 87,000
50,000(16) 116,000
(1)
The market value of the RSU awards is based on the closing price of our common stock as reported on the Nasdaq Global Select Market on December 29, 2023, which was $2.32.
(2)
Represents an option to purchase shares of our common stock granted on June 8, 2023, which will vest in full on June 8, 2024, subject to Dr. Huber’s continued service as a director on such vesting date.
(3)
Represents an option to purchase shares of our common stock granted on September 11, 2023, which will vest as to 25% of the shares on September 11, 2024, and will vest as to the remainder of the shares in quarterly installments thereafter through September 11, 2027, subject to Dr. Huber’s continued employment through each applicable vesting date.
(4)
Represents an award of RSUs granted on September 11, 2023, which vests in equal annual installments through September 11, 2027, subject to Dr. Huber’s continued employment through each applicable vesting date.
(5)
Represents an option to purchase shares of our common stock granted on January 15, 2020, which vested in equal quarterly installments through January 15, 2024.
(6)
Notwithstanding the terms otherwise applicable to this equity award, any equity awards held by Ms. Protopapas shall continue to vest through January 31, 2025, subject to Ms. Protopapas’ continued service to the Company as of such date.
(7)
Represents an option to purchase shares of our common stock granted on January 14, 2022, which vests in equal quarterly installments through January 14, 2026, subject to the named executive officer’s continued employment through each applicable vesting date.
(8)
Represents an option to purchase shares of our common stock granted on January 13, 2023, which vests in equal quarterly installments through January 13, 2027, subject to the named executive officer’s continued employment through each applicable vesting date.
(9)
Represents an option to purchase shares of our common stock granted on September 11, 2023, which will vest in full on June 8, 2024, subject to Ms. Protopapas’ continued service to the Company as a director through such date.
 
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(10)
Represents an award of RSUs granted on January 15, 2020, which vested in equal annual installments through January 15, 2024.
(11)
Represents an award of RSUs granted on January 15, 2021, which vests in equal annual installments through January 15, 2025, subject to the named executive officer’s continued employment through each applicable vesting date.
(12)
Represents an award of RSUs granted on January 14, 2022, which vests in equal annual installments through January 14, 2026, subject to the named executive officer’s continued employment through each applicable vesting date.
(13)
Represents an award of RSUs granted on January 13, 2023, which vests in equal annual installments through January 13, 2027, subject to the named executive officer’s continued employment through each applicable vesting date.
(14)
Represents an award of RSUs granted on September 11, 2023, which vests in full on June 8, 2024, subject to Ms. Protopapas’ continued service to the Company as a director through such date.
(15)
Represents an option to purchase shares of our common stock granted on January 15, 2021, which vests in equal quarterly installments through January 15, 2025, subject to the named executive officer’s continued employment through each applicable vesting date.
(16)
Represents an award of RSUs granted on September 5, 2023, which vests in full on October 1, 2024, subject to the named executive officer’s continued employment through such date.
(17)
Represents an option to purchase shares of our common stock granted on October 25, 2021, which vested as to 25% of the shares on October 25, 2022, and vests as to the remainder of the shares in quarterly installments thereafter through October 25, 2025, subject to Dr. Bala’s continued employment through each applicable vesting date. This was an inducement award granted pursuant to the inducement grant exception under Nasdaq Stock Market Rule 5635(c), which inducement award was not granted under our 2017 Stock Incentive Plan or the Mersana Therapeutics, Inc.2022 Inducement Stock Incentive Plan, or the 2022 Inducement Plan.
(18)
Represents an award of RSUs granted on October 25, 2021, which vests in equal annual installments through October 25, 2025, subject to Dr. Bala’s continued employment through each applicable vesting date.
(19)
Represents an option to purchase shares of our common stock granted on April 26, 2021, which vested as to 25% of the shares on April 26, 2022, and vests as to the remainder of the shares in quarterly installments thereafter through April 26, 2025, subject to Ms. Carvajal’s continued employment through each applicable vesting date. This was an inducement award granted pursuant to the inducement grant exception under Nasdaq Stock Market Rule 5635(c), which inducement award was not granted under our 2017 Stock Incentive Plan or our 2022 Inducement Plan.
 
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Option Exercises and Stock Vested
The following table sets forth the value received by our named executive officers upon the exercise of stock options and/or the vesting of stock awards, in each case, during 2023.
Option Awards
Stock Awards
Name
Number of
shares
acquired
on exercise
(#)
Value
realized on
exercise
($)
Number of
shares
acquired
on vesting
(#)
Value
realized on
vesting(1)
($)
Martin Huber, M.D.
Anna Protopapas
55,708 337,590
Brian DeSchuytner
16,458 99,735
Mohan Bala, Ph.D.
6,250 6,938
Alejandra Carvajal
15,750 66,693
Timothy B. Lowinger, Ph.D.
20,001 121,206
Arvin Yang, M.D.
7,084 42,929
(1)
Amount represents the closing price of our common stock on the applicable vesting date multiplied by the number of RSUs vesting on such date.
Employment Arrangements
Letter Agreements
Each of our currently serving named executive officers is, and each formerly serving named executive officer was, party to a letter agreement with us that sets forth the terms and conditions of the executive’s employment with us. Each letter agreement provides for at-will employment with us. Each letter agreement sets forth the executive’s base salary, which is eligible for potential discretionary merit increases, and target annual bonus (expressed as a percentage of base salary). Each of our named executive officers is also party to our standard nondisclosure, noncompetition and assignment of intellectual property agreement. Pursuant to their letter agreements, each of the named executive officers is or was also entitled to certain compensation and benefits upon termination of his or her employment in certain circumstances, including following a change in control. The severance benefits provided under these letter agreements are described under “— Payments on Termination of Employment or Change in Control Benefits” below.
Retirement and Separation Agreement with Ms. Protopapas
In connection with Ms. Protopapas’ retirement as our President and Chief Executive Officer effective September 10, 2023, on September 5, 2023, we entered into a retirement and separation agreement, or the Protopapas Retirement Agreement, with Ms. Protopapas. Pursuant to the Protopapas Retirement Agreement, we agreed to pay Ms. Protopapas the annual cash bonus under our 2017 Cash Bonus Plan to which Ms. Protopapas would have been entitled for the fiscal year ending December 31, 2023 had she remained employed by us through such date, pro-rated for the portion of 2023 for which Ms. Protopapas was actually employed us. Pursuant to the Protopapas Retirement Agreement, such cash bonus was to be based on our corporate performance as assessed by our Board of Directors or a duly authorized committee thereof following December 31, 2023. In addition, pursuant to the Protopapas Retirement Agreement, (i) the stock option granted to Ms. Protopapas on January 15, 2021, or the 2021 Option, ceased vesting on September 10, 2023, following which date Ms. Protopapas had a period of three months to exercise the vested portion of the 2021 Option, (ii) we agreed to extend the vesting of Ms. Protopapas’ outstanding stock options and RSU awards, other than the 2021 Option, through January 31, 2025, subject to Ms. Protopapas’ continued service to the Company as a director through such date, and (iii) other than with respect to the 2021 Option, the exercise period for each vested stock option held by Ms. Protopapas will expire upon the earlier of the end of the applicable term of the option and three months after Ms. Protopapas ceases to be a member of our Board of Directors. The Protopapas Retirement Agreement also included a general release of claims by Ms. Protopapas.
 
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Following her retirement, Ms. Protopapas has received and will continue to receive compensation for her continued service as a member of our Board of Directors in accordance with our NED Compensation Policy and our Amended NED Compensation Policy. Pursuant to the Protopapas Retirement Agreement, on September 11, 2023, our Board of Directors also granted Ms. Protopapas an equity award in the form of (i) an option to purchase 16,643 shares of our common stock and (ii) a RSU award for 16,643 shares of our common stock, each of which will vest in full on June 8, 2024, subject to Ms. Protopapas’ continuous service to us on such vesting date. These equity awards were granted pursuant to our 2017 Stock Incentive Plan and were calculated based on the terms of the annual equity grant for which non-employee directors were eligible under the NED Compensation Policy, pro-rated for the portion of the year for which Ms. Protopapas will serve as a non-employee director following our 2023 Annual Meeting.
Pension Benefits
Other than with respect to tax-qualified defined contribution plans such as our 401(k) plan, our named executive officers do not participate in any plan that provides for retirement payments and benefits, or payments and benefits that will be provided primarily following retirement.
Nonqualified Deferred Compensation
None of our named executive officers participate in or have account balances in qualified or nonqualified defined benefit plans sponsored by us that provide for the deferral of compensation on a basis that is not tax-qualified. Our Compensation Committee may elect to adopt qualified or nonqualified defined benefit plans in the future if it determines that doing so is in our best interests.
Payments on Termination of Employment or Change in Control Benefits
Pursuant to their letter agreements, each of our named executive officers is (or, in the cases of Ms. Protopapas and Dr. Yang was, prior to her retirement and his departure from the Company, respectively) entitled to severance payment and benefits upon terminations of their employment in certain circumstances, including following a Change in Control, as summarized below. The terms “Disqualifying Conduct,” “Cause,” “Good Reason” and “Change in Control” referred to below are defined in the applicable letter agreement and are summarized below.
Termination of Employment without Cause or other than for Disqualifying Conduct or for Good Reason.   If the executive’s employment is terminated (a)(i) by us without Cause, for Mr. DeSchuytner and Dr. Lowinger, or (ii) by us other than for Disqualifying Conduct, for Drs. Huber, Bala and Yang and Ms. Carvajal, or (b) by the executive for Good Reason; then, the executive will be entitled to receive continued payment of his or her base salary for twelve months, for Dr. Huber, or nine months, for Drs. Bala, Lowinger and Yang, Ms. Carvajal and Mr. DeSchuytner, following such termination of employment. In addition, if the executive elects to continue coverage in our group health plans, we will pay a portion of the COBRA or state law premiums equal to the excess of the cost of such premiums over the amount the executive would have paid for coverage for the executive, his or her spouse and dependents had the executive remained employed by the Company, for twelve months, for Dr. Huber, or nine months, for Drs. Bala, Lowinger and Yang, Ms. Carvajal and Mr. DeSchuytner.
Termination of Employment without Cause or other than for Disqualifying Conduct or for Good Reason following a Change in Control.   If the executive’s employment is terminated (a)(i) by us without Cause, for Mr. DeSchuytner and Dr. Lowinger, or (ii) by us other than for Disqualifying Conduct, for Drs. Huber, Bala and Yang and Ms. Carvajal, or (b) by the executive for Good Reason, in any case within twelve months following a change in control; then, the executive will be entitled to receive a lump sum payment equal to the sum of (A) eighteen months’ of base salary, for Dr. Huber, or twelve months’ of base salary, for Drs. Bala, Lowinger and Yang, Ms. Carvajal and Mr. DeSchuytner, and (B) the executive’s target annual bonus, multiplied by 1.5, for Dr. Huber, or by one, for Drs. Bala, Lowinger and Yang, Ms. Carvajal and Mr. DeSchuytner. If the executive elects to continue coverage in our group health plans, we will pay a portion of the COBRA or state law premiums equal to the excess of the cost of such premiums over the amount the executive would have paid for coverage for the executive, his or her spouse and dependents had the executive remained employed by the Company, for eighteen months, for Dr. Huber, or twelve months, for Drs. Bala, Lowinger and Yang, Ms. Carvajal and Mr. DeSchuytner. In addition, any stock options or
 
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other equity-based awards held by the executive, to the extent outstanding immediately prior to such termination of employment, will vest in full as of immediately prior to such termination.
Severance Subject to Release of Claims and Continued Compliance with Restrictive Covenants.   Our obligation to provide an executive with severance payments and other benefits under the executive’s letter agreement is conditioned on the executive signing (and not subsequently revoking) an effective release of claims in favor of the company and the executive’s continued compliance with his or her nondisclosure, noncompetition and assignment of intellectual property agreement, the noncompetition and non-solicitation provisions of which generally survive for twelve months following the termination of employment and the nondisclosure provisions of which generally survive indefinitely.
Section 280G.   In the event that all or any portion of the payments or benefits provided under an executive’s letter agreement would constitute an “excess parachute payment” within the meaning of Section 280G of the Code, the executive will be entitled to receive an amount equal to the greater of (i) the amount of such payments or benefits reduced so that no portion of the payments and benefits would fail to be deductible under Section 280G of the Code, or (ii) the amount otherwise payable reduced by all taxes, including the excise tax imposed under Section 4999 of the Code.
For the purposes of the letter agreements:

“Cause” generally means: (i) willful misconduct or gross negligence as to a material matter in connection with the executive’s duties; (ii) any act constituting material dishonesty or fraud with respect to the Company; (iii) the indictment for, conviction of, or a plea of guilty or nolo contendere to, a felony under applicable law; (iv) material violation of a material term of any written Company policy; (v) failure to attempt in good faith to (A) perform the executive’s duties in all material respects or (B) follow a clear, lawful, and reasonable directive of the Board; or (vi) material breach of a fiduciary duty owed to the Company that has caused or could reasonably be expected to cause a material injury to the business.

“Disqualifying Conduct” generally means: (i) willful misconduct or gross negligence as to a material matter in connection with the executive’s duties; (ii) any act constituting material dishonesty or fraud with respect to the Company; (iii) the indictment for, conviction of, or a plea of guilty or nolo contendere to, a felony under applicable law; (iv) material violation of a material term of any written Company policy; (v) failure to attempt in good faith to (A) perform the executive’s duties in all material respects or (B) follow a clear, lawful, and reasonable directive of the Board; or (vi) material breach of a fiduciary duty owed to the Company that has caused or could reasonably be expected to cause a material injury to the business.

“Good Reason” generally means, without the executive’s consent: (i) a material decrease in the executive’s base salary; (ii) a material diminution in the executive’s authorities, duties, or responsibilities; or (iii) the relocation of the executive’s principal work location to a location more than fifty (50) miles from its current location.

“Change in Control” generally means a “change in control event” as that term is defined in the regulations under Section 409A of the Code.
Potential Payments Upon Termination or Change of Control
The following table sets forth information regarding potential payments that would have been made to our named executive officers, other than Ms. Protopapas and Dr. Yang, in connection with a qualifying termination of employment, including in connection with a change in control, assuming such termination of employment and change in control occurred on December 31, 2023. Ms. Protopapas retired as our President and Chief Executive Officer effective September 10, 2023, and we entered into the Protopapas Retirement Agreement with her at such time. The payments listed in the row labeled “Retirement” in the table below reflect the actual amounts payable to Ms. Protopapas pursuant to the Protopapas Retirement Agreement. Dr. Yang’s employment by the Company ended on September 30, 2023, his termination of employment was treated as a termination of employment other than for Disqualifying Conduct pursuant to his employment offer letter, and he was entitled to the actual payments listed below. None of our named executive officers who do not also serve as members of our Board of Directors are entitled to any “single-trigger” change in
 
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control payments or benefits, and none of our named executive officers are entitled to any severance payments in connection with a termination of their employment under any circumstances other than as noted in the table below. Each of Dr. Huber and Ms. Protopapas hold equity awards granted to them for their service as a non-employee director pursuant to our NED Compensation Policy, which awards will vest in full upon a change in control pursuant to our NED Compensation Policy, as reflected in the table below.
Name
Cash
Severance
Benefits(1)
($)
COBRA
Premiums(2)
($)
Value of
Accelerated
Equity(3)
($)
Incremental
Fair Value of
Modified
Equity
Awards(4)
($)
Total(5)
($)
Martin Huber, M.D.
Termination without Cause or resignation for
Good Reason
625,000 18,578 643,578
Change of Control
42,584(6) 42,584
Termination without Cause or resignation for
Good Reason on or within 12 months
following Change in Control
1,000,000 27,867 3,910,024 4,937,891
Anna Protopapas
Retirement
135,164 294,907 430,071
Change of Control
77,224(6) 77,224
Brian DeSchuytner
Termination without Cause or resignation for
Good Reason
333,356 6,629 339,985
Termination without Cause or resignation for
Good Reason on or within 12 months
following Change in Control
622,265 8,839 868,494 1,499,598
Alejandra Carvajal
Termination other than for Disqualifying Conduct or resignation for Good Reason
322,920 18,958 341,878
Termination other than for Disqualifying
Conduct or resignation for Good Reason
on or within 12 months following Change in
Control
602,784 25,277 677,087 1,305,148
Timothy B. Lowinger, Ph.D.
Termination without Cause or resignation for
Good Reason
352,547 18,958 371,505
Termination without Cause or resignation for
Good Reason on or within 12 months
following Change in Control
658,088 25,277 835,019 1,518,384
Arvin Yang, M.D.
Termination other than for Disqualifying Conduct or resignation for Good Reason
409,744 18,958 428,701
(1)
Amounts represent, for our named executive officers other than Ms. Protopapas, the cash severance benefits payable to our named executive officers under their letter agreements, based on the named executive officer’s base salary and target annual bonus as in effect on December 31, 2023 (or as of September 30, 2023 for Dr. Yang) and for Ms. Protopapas, the cash severance benefits payable to her pursuant to the Protopapas Retirement Agreement, which consisted of the annual cash bonus under
 
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our 2017 Cash Bonus Plan to which Ms. Protopapas would have been entitled for the fiscal year ending December 31, 2023 had she remained employed by us through such date, pro-rated for the portion of 2023 for which Ms. Protopapas was actually employed us. See the section entitled “Compensation Discussion and Analysis — Elements of Our Executive Compensation Program — Annual Performance-Based Cash Compensation — 2023 Corporate Performance Goals,” for a discussion of this amount.
(2)
Amounts represent the estimated cost of Company-paid portion of COBRA premiums based on the estimated cost of such coverage as of December 31, 2023.
(3)
Except as otherwise noted, amounts represent the value of unvested stock options and RSUs held by the named executive officer on December 31, 2023 for which vesting will be accelerated, based on the closing price of a share of our common stock as reported on the Nasdaq Global Select Market on December 29, 2023, which was $2.32.
(4)
Represents incremental fair value recognized in connection with modification of Ms. Protopapas’ outstanding option awards under our 2007 Stock Incentive Plan in order to permit such options to remain outstanding during her period of service as a non-employee director, which modification occurred pursuant to the Protopapas Retirement Agreement.
(5)
The amounts reported in this table do not include any potential reduction in payments or benefits that may be made as a result of Sections 280G or 4999 of the Code.
(6)
Represents the value of unvested director stock options held by Dr. Huber and Ms. Protopapas and unvested director RSUs held by Ms. Protopapas on December 31, 2023 for which vesting will be accelerated upon a change in control pursuant to our NED Compensation Policy, based on the closing price of a share of our common stock as reported on the Nasdaq Global Select Market on December 29, 2023, which was $2.32.
 
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SECURITIES AUTHORIZED FOR ISSUANCE UNDER EQUITY COMPENSATION PLANS
The following table provides information about the securities authorized for issuance under our equity compensation plans as of December 31, 2023. As of December 31, 2023, we had four equity compensation plans. Three of these plans, our 2007 Stock Incentive Plan, our 2017 Stock Incentive Plan and the Mersana Therapeutics, Inc. 2017 Employee Stock Purchase Plan, or 2017 ESPP, were approved by our stockholders. On February 24, 2022, our Board of Directors adopted, upon recommendation of the Compensation Committee, our 2022 Inducement Stock Incentive Plan, or the 2022 Inducement Plan, which became effective immediately. The 2022 Inducement Plan provides for the grant of nonstatutory stock options, stock appreciation rights, restricted stock, RSUs, and other stock-based awards with respect to an aggregate of 2,000,000 shares of our common stock (subject to adjustment as provided in the 2022 Inducement Plan). Awards under the 2022 Inducement Plan may only be granted to persons who (a) were not previously our employee or director or (b) are commencing employment with us following a bona fide period of non-employment, in either case as an inducement material to the individual’s entering into employment with us and in accordance with the requirements of Nasdaq Stock Market Rule 5635(c)(4).
Equity Compensation Plan Information
Plan Category
Number of
securities to be
issued upon
exercise of
outstanding
options and
rights (a)
Weighted
average
exercise
price of
outstanding
options and
rights (b)(1)
Number of securities
remaining available for
future issuance under
equity compensation
plans (excluding
securities reflected in
column (a)) (c)(2)
Equity compensation plans approved by security holders
13,513,828(3) $ 7.25 2,422,078
Equity compensation plans not approved by security holders 
1,208,658(4) $ 9.52 1,170,752
Total
14,722,486 $ 7.42 3,592,830(5)
(1)
Determined without taking into account RSUs, which do not have an exercise price.
(2)
As of December 31, 2023, (i) 2,057,795 shares remained available for future issuance under our 2017 Stock Incentive Plan and (ii) 364,283 shares remained available for future issuance under our 2017 ESPP. No shares remained available for future issuance under our 2007 Stock Incentive Plan as of December 31, 2023, but in the event of any forfeitures or cancellations of awards under the 2007 Stock Incentive Plan, up to 1,314,892 shares thereunder may become available for future issuance under our 2017 Stock Incentive Plan.
(3)
Includes shares subject to options to purchase shares of our common stock and awards of RSUs.
(4)
Represents inducement stock option awards granted to certain employees of the Company in accordance with Nasdaq Listing Rule 5635(c)(4) and inducement stock option awards and awards of RSUs granted pursuant to our 2022 Inducement Plan.
(5)
Our 2017 Stock Incentive Plan has an evergreen provision that provides for an annual increase in the number of shares available for issuance thereunder to be added on the first day of each fiscal year in an amount equal to 4% of the number of shares of our common stock outstanding on the immediately preceding December 31 or such lesser amount determined by our Board of Directors. Our 2017 ESPP has an evergreen provision that allows for an annual increase in the number of shares available for issuance thereunder to be added on the first day of each fiscal year in an amount equal to the least of (i) 450,000 shares of common stock, (ii) 1% of the total number of shares of our common stock outstanding on the immediately preceding December 31 or (iii) such lesser amount determined by our Board of Directors (but in no event may more than 4,725,000 shares become available for issuance under our 2017 ESPP). In January 2024, the number of shares available for issuance under our 2017 Stock Incentive Plan and our 2017 ESPP increased by 4,828,469 and 450,000 shares, respectively.
 
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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
The following table sets forth certain information as of April 15, 2024 (unless otherwise specified), with respect to the beneficial ownership of our common stock by each person who is known to own beneficially more than 5% of the outstanding shares of common stock, each person currently serving as a director, each nominee for director, each named executive officer (as set forth in the 2023 Summary Compensation Table above) and all directors and executive officers as a group. The number of shares beneficially owned by each entity or person is determined in accordance with the rules of the SEC, and the information is not necessarily indicative of beneficial ownership for any other purpose. Under such rules, beneficial ownership includes any shares over which the individual has sole or shared voting power or investment power as well as any shares that the individual has the right to acquire within 60 days of April 15, 2024 through the exercise of any stock options, warrants or other rights or upon the vesting of any RSUs. Except as otherwise indicated, and subject to applicable common property laws, the persons in the table have sole voting and investment power with respect to all shares of common stock held by that person.
Shares of common stock subject to options, warrants or other rights that are now exercisable or are exercisable within 60 days after April 15, 2024 are considered outstanding for purposes of computing the percentage ownership of the persons holding these options, warrants or other rights but are not to be considered outstanding for the purpose of computing the percentage ownership of any other person. As of April 15, 2024, there were 122,361,236 shares of common stock outstanding. Unless otherwise indicated, the address for each beneficial owner is c/o Mersana Therapeutics, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139.
Name and address of beneficial owner
Number of shares
beneficially owned
Percentage of shares
beneficially owned
5% or greater stockholders:
Entities affiliated with EcoR1 Capital, LLC(1)
19,364,688 15.8%
Entities affiliated with Venrock Healthcare Capital Partners III, L.P.(2)
11,328,000 9.3%
Entities affiliated with Balyasny Asset Management L.P.(3)
9,698,673 7.9%
Entities affiliated with Bain Capital Life Sciences(4)
8,663,673 7.1%
Blackrock, Inc.(5)
7,844,282 6.4%
SilverArc Capital Management, LLC(6)
6,420,136 5.2%
The Vanguard Group, Inc.(7)
6,237,588 5.1%
Directors and named executive officers:
Lawrence M. Alleva(8)
250,353 *
Willard H. Dere, M.D.(9)
222,658 *
Allene M. Diaz(10)
127,513 *
Andrew A. F. Hack, M.D., Ph.D.(11)
8,876,933 7.2%
Kristen M. Hege, M.D.(12)
250,156 *
Martin Huber, M.D.(13)
178,575 *
David Mott(14)
805,556 *
Anna Protopapas(15)
2,509,889 2.0%
Mohan Bala, Ph.D.(16)
149,989 *
Alejandra Carvajal(17)
201,545 *
Brian DeSchuytner(18)
593,104 *
Timothy B. Lowinger, Ph.D.(19)
756,213 *
Arvin Yang, M.D.
30,821 *
All executive officers and directors as a group (13 persons)(20)
15,085,121 11.8%
*
Represents beneficial ownership of less than one percent of our outstanding common stock.
(1)
As reported on a Schedule 13G filed with the SEC on July 27, 2023 by EcoR1 Capital, LLC, Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. (“Qualified Fund” and together with EcoR1 Capital,
 
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LLC and Mr. Nodelman, the “EcoR1 Parties”). Each of EcoR1 Capital, LLC and Mr. Nodelman has shared voting and dispositive power with respect to 19,364,688 shares. Qualified Fund has shared voting and dispositive power with respect to 18,260,899 shares. Qualified Fund disclaims membership in a group with EcoR1 Capital, LLC and Mr. Nodelman and disclaims that it is a beneficial owner of any shares reported. Each of the EcoR1 Parties disclaims beneficial ownership of the shares except to the extent of each such person’s pecuniary interest therein. The principal business address of the EcoR1 Parties is 357 Tehama Street #3, San Francisco, CA 94103.
(2)
As reported on a Schedule 13G/A filed with the SEC on February 14, 2024 by Venrock Healthcare Capital Partners III, L.P.; VHCP Co-Investment Holdings III, LLC; Venrock Healthcare Capital Partners EG, L.P.; VHCP Management III, LLC; VHCP Management EG, LLC; Nimish Shah and Bong Koh (collectively, the “Venrock Parties”). Consists of (i) 2,978,132 shares held by Venrock Healthcare Capital Partners III, L.P.; (ii) 297,926 shares held by VHCP Co-Investment Holdings III, LLC; and (iii) 8,051,942 shares held by Venrock Healthcare Capital Partners EG, L.P. Management III, LLC is the general partner of Venrock Healthcare Capital Partners III, L.P. and the manager of VHCP Co-Investment Holdings III, LLC. VHCP Management EG, LLC is the general partner of Venrock Healthcare Capital Partners EG, L.P. Messrs. Shah and Koh are the voting members of VHCP Management III, LLC and VHCP Management EG, LLC. According to the Schedule 13G, each of the Venrock Parties has shared voting and dispositive power with respect to 11,328,000 shares. The principal business address of the Venrock Parties is 7 Bryant Park, 23rd Floor, New York, NY 10018.
(3)
As reported on a Schedule 13G filed with the SEC on February 14, 2024 by Balyasny Asset Management L.P. (“BAM”); BAM GP LLC (“BAM GP”); Balyasny Asset Management Holdings LP (“BAM Holdings”); Dames GP LLC (“Dames”); and Dmitry Balyasny (together with BAM, BAM GP, BAM Holdings and Dames, the “Balyasny Parties”). Consists of shares held by Atlas Diversified Master Fund, Ltd. (“ADMF”), which has the right to receive dividends from, or the proceeds from the sale of, the shares. By virtue of its position as the investment manager of ADMF, BAM may be deemed to exercise voting and investment power over such shares held by ADMF and thus may be deemed to beneficially own such shares. By virtue of its position as the general partner of BAM, BAM GP may be deemed to exercise voting and investment power over the shares held directly by ADMF and thus may be deemed to beneficially own such shares. By virtue of its position as the sole member of BAM GP, BAM Holdings may be deemed to exercise voting and investment power over the shares held directly by ADMF and thus may be deemed to beneficially own such shares. By virtue of its position as the general partner of BAM Holdings, Dames may be deemed to exercise voting and investment power over the shares held directly by ADMF and thus may be deemed to beneficially own such shares. By virtue of his position as the managing member of Dames, Mr. Balyasny may be deemed to exercise voting and investment power over the shares held directly by ADMF and thus may be deemed to beneficially own such shares. Each of the Balyasny Parties has shared voting and dispositive power with respect to all of the shares of common stock. The principal business address of the Balyasny Parties is 444 West Lake Street, 50th Floor, Chicago, IL 60606.
(4)
Based in part on a Schedule 13D/A filed with the SEC on May 11, 2022 by Bain Capital Life Sciences Fund II, L.P. (“BCLS II”), BCIP Life Sciences Associates, LP (“BCIPLS”) and BCLS II Investco, LP (“BCLS II Investco” and, together with BCLS II and BCIPLS, the “Bain Capital Life Sciences Entities”) and in part on Forms 4 filed with the SEC by Dr. Hack on May 18, 2022; May 23, 2022; May 26, 2022, June 2, 2022 and June 12, 2023 (collectively, the “Hack Forms 4”). According to the Schedule 13D/A, BCLS II holds 3,294,423 shares, BCIPLS holds 401,244 shares, and BCLS II Investco holds 4,041,733 shares, over which shares each applicable Bain Capital Life Sciences Entity has shared voting and dispositive control. According to the Hack Forms 4, the Bain Capital Life Sciences Entities acquired an aggregate of 926,273 additional shares subsequent to the date of the Schedule 13D/A. Bain Capital Life Sciences Investors, LLC (“BCLSI”) (i) is the manager of Bain Capital Life Sciences Investors II, LLC, which is the general partner of BCLS II, and (ii) governs the investment strategy and decision-making process with respect to investments held by BCIPLS. BCLS II is the manager of BCLS II Investco (GP), LLC, which is the general partner of BCLS II Investco. As a result, BCLSI may be deemed to share voting and dispositive power with respect to the securities held by the Bain Capital Life Sciences Entities. Dr. Hack is a Partner of BCLSI. As a result, Dr. Hack may be deemed to share voting and dispositive power with respect to the shares held by the Bain Capital Life Sciences Entities. Dr. Hack disclaims beneficial ownership of such shares except to the extent of his pecuniary
 
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interest therein. The principal business address of each of the Bain Capital Life Sciences Entities is c/o Bain Capital Life Sciences, LP, 200 Clarendon Street, Boston, MA 02116.
(5)
As reported on a Schedule 13G/A filed with the SEC on January 29, 2024 by BlackRock, Inc. BlackRock has sole voting power with respect to 7,745,336 shares and sole dispositive power with respect to 7,844,282 shares. The principal business address of BlackRock Inc. is 50 Hudson Yards, New York, NY 10001.
(6)
As reported on a Schedule 13G filed with the SEC on February 14, 2024 by SilverArc Capital Management, LLC (“SilverArc”) and Devesh Gandhi. SilverArc is deemed to be the beneficial owner of 6,420,136 shares as a result of acting as investment adviser to various clients. Mr. Gandhi is the Sole Member of SilverArc and as such is deemed to be the beneficial owner of such shares. Clients of SilverArc have the right to receive and the ultimate power to direct the receipt of dividends from, or the proceeds of the sale of, such securities. SilverArc Capital Alpha Fund I, L.P., for which SilverArc acts as an investment adviser, may be deemed to beneficially own 219,229 of these 6,420,136 shares. SilverArc Capital Alpha Fund II, L.P., for which SilverArc acts as an investment adviser, may be deemed to beneficially own 4,065,870 of these 6,420,136 shares. Squarepoint Diversified Partners Fund Limited, for which SilverArc acts as investment adviser, may be deemed to beneficially own 1,420,119 of these 6,420,136 shares. Atom Master Fund L.P., a Cayman Islands exempted limited partnership for which SilverArc acts as investment adviser, may be deemed to beneficially own 714,918 of these 6,420,136 shares. The principal business address of SilverArc and Mr. Gandhi is 20 Park Plaza, 4th Floor, Boston, MA 02116.
(7)
As reported on a Schedule 13G filed with the SEC on February 13, 2024 by The Vanguard Group, Inc. (“Vanguard”). Consists of 130,069 shares over which Vanguard has shared voting power; 6,066,644 shares over which Vanguard has sole dispositive power; and 170,944 shares over which Vanguard has shared dispositive power. Vanguard’s clients have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the shares. The principal business address of Vanguard is 100 Vanguard Blvd., Malvern, PA 19355.
(8)
Consists of (a) 2,120 shares of common stock held by the Lawrence M. Alleva Revocable Trust, (b) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (c) options to purchase 233,766 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(9)
Includes (a) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (b) options to purchase 183,476 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(10)
Includes (a) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (b) options to purchase 113,046 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(11)
Consists of (a) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024, (b) options to purchase 198,793 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date and (c) the shares of common stock held by the Bain Capital Life Sciences Entities described in footnote (4) above. Dr. Hack is a Partner of BCLSI. As a result, by virtue of the relationships described in footnote (4) above, Dr. Hack may be deemed to share beneficial ownership of the shares of common stock held by the Bain Capital Life Sciences Entities. Dr. Hack disclaims beneficial ownership of the shares held by the Bain Capital Life Sciences Entities except to the extent of his pecuniary interest therein. Dr. Hack’s business address is c/o Bain Capital Life Sciences, LP, 200 Clarendon Street, Boston, MA 02116.
(12)
Includes (a) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (b) options to purchase 235,689 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(13)
Includes options to purchase 178,575 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(14)
Consists of (a) 574,227 shares of common stock held by Mr. Mott, (b) 9,595 shares held by the David Mott Declaration of Trust dated May 31, 2001, as amended, (c) 14,467 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (d) options to
 
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purchase 207,267 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(15)
Consists of (a) 108,510 shares of common stock held by Ms. Protopapas, (b) 72,263 shares held by the Kinney/ Protopapas Irrevocable Trust, (c) 240,244 shares held by the Anna Protopapas Irrevocable Trust, (d) 16,643 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (e) options to purchase 2,072,229 shares common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(16)
Includes options to purchase 135,937 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(17)
Includes options to purchase 174,142 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(18)
Includes options to purchase 538,593 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(19)
Includes options to purchase 556,884 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
(20)
Includes (a) 103,455 shares of common stock underlying restricted stock units that will vest within 60 days of April 15, 2024 and (b) options to purchase 4,973,068 shares of common stock that were exercisable as of April 15, 2024 or will become exercisable within 60 days after such date.
 
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PROPOSAL NO. 3 — RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2024
Our stockholders are being asked to ratify the appointment by the Audit Committee of the Board of Directors of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024. Ernst & Young has served as our independent registered public accounting firm since 2013.
The Audit Committee is solely responsible for selecting our independent registered public accounting firm for the fiscal year ending December 31, 2024. Stockholder approval is not required to appoint Ernst & Young LLP as our independent registered public accounting firm. However, our Board of Directors believes that submitting the appointment of Ernst & Young LLP to the stockholders for ratification is good corporate governance. If the stockholders do not ratify this appointment, the Audit Committee will reconsider whether to retain Ernst & Young LLP. If the selection of Ernst & Young LLP is ratified, the Audit Committee, in its discretion, may direct the appointment of a different independent registered public accounting firm at any time it decides that such a change would be in the best interest of our Company and our stockholders.
A representative of Ernst & Young LLP is expected to attend the virtual Annual Meeting and will have an opportunity to make a statement if he or she desires to do so and to respond to appropriate questions from our stockholders.
Principal Accountant Fees and Services
We regularly review the services and fees of our independent registered public accounting firm. These services and fees are also reviewed by the Audit Committee on an annual basis. The aggregate fees billed for the fiscal years ended December 31, 2023 and 2022 for each of the following categories of services are as follows (in thousands):
Fee Category
2023
2022
Audit Fees(1)
$ 889,483 $ 976,680
Audit-Related Fees(2)
$ $ 57,040
Tax Fees(3)
$ 73,475 $ 43,351
All Other Fees
$ $
Total Fees
$ 962,958 $ 1,077,071
(1)
Audit fees in 2023 and 2022 include fees related to the annual audit of the Company’s financial statements, the review of the interim financial statements included in our quarterly reports on Form 10-Q, and comfort letters, consents and assistance with and review of documents filed with the SEC.
(2)
Audit-related fees are related to accounting consultations.
(3)
Tax fees are related to tax compliance, tax advice and tax planning services, including the review and preparation of our federal and state income tax returns.
The Audit Committee pre-approved all services described above in accordance with the pre-approval policies and procedures described below.
Audit Committee Pre-Approval Policy and Procedures
The Audit Committee pre-approves all auditing services, internal control related services and permitted non-audit services (including the fees and terms thereof) to be performed by Ernst & Young, subject to the de minimis exception for non-audit services that are approved by the Audit Committee prior to the completion of an audit. The Audit Committee may delegate pre-approval authority to one or more members of the Audit Committee consistent with applicable law and listing standards, provided that the decisions of such Audit Committee member or members must be communicated to the Audit Committee at its next scheduled meeting.
 
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Recommendation of the Board of Directors
OUR BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS THAT STOCKHOLDERS
VOTE “FOR” THE RATIFICATION OF THE SELECTION OF ERNST & YOUNG LLP
AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR
THE FISCAL YEAR ENDING DECEMBER 31, 2024.
 
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AUDIT COMMITTEE REPORT
The Audit Committee has reviewed our audited financial statements for the year ended December 31, 2023 and discussed them with our management and our independent registered public accounting firm, Ernst &Young LLP.
The Audit Committee has also received from, and discussed with, Ernst &Young LLP various communications that Ernst &Young LLP is required to provide to the Audit Committee, including the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board and the SEC.
In addition, Ernst & Young LLP provided the Audit Committee with the written disclosures and the letter required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and the Audit Committee has discussed with the Company’s independent registered public accounting firm their independence.
Based on the review and discussions referred to above, the Audit Committee recommended to our Board of Directors that our financial statements audited by Ernst & Young LLP be included in our Annual Report on Form 10-K for the year ended December 31, 2023.
Members of the Audit Committee of Mersana Therapeutics, Inc.
Lawrence M. Alleva, Chair
Willard H. Dere
Andrew A. F. Hack
 
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CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS
The following is a description of transactions since January 1, 2022 to which we have been a party, and in which any of our directors, executive officers and holders of 5% or more of our voting securities and affiliates of these persons had or will have a direct or indirect material interest. We believe that all of the transactions described below were made on terms no less favorable to us than could have been obtained from unaffiliated third parties.
Bain Capital Life Sciences At-the-Market Purchases
In the year ended December 31, 2022, entities affiliated with Bain Capital Life Sciences Investors, LLC, of which Dr. Hack is a partner, purchased an aggregate of 2,351,733 shares of our common stock in three transactions through our at-the-market offering, or ATM, program, for which Cowen & Company served as Sales Agent and for which we received gross proceeds of approximately $10.0 million. The purchase of all such shares of common stock made by the affiliates of Bain Capital Life Sciences Investors, LLC through our ATM program were made at market prices in sales deemed to be an “at the market” offering under Rule 415 of the Securities Act of 1933, as amended, and were approved by our Audit Committee pursuant to the Related Party Transactions Policy described below.
Indemnification Agreements and Directors’ and Officers’ Liability Insurance
We have entered into indemnification agreements with each of our directors and executive officers. We also maintain a general liability insurance policy, which covers certain liabilities of directors and officers of the Company arising out of claims based on acts or omissions in their capacities as directors or officers.
Employment Agreements
See the “Executive Compensation — Employment, Severance, Change in Control Arrangements, and Separation Arrangements” and “Director Compensation” sections of this proxy statement for a further discussion of these arrangements.
Related Party Transactions Policy
We have adopted a written related party transactions policy that governs the review and approval of related party transactions. Pursuant to this policy, if we want to enter into a transaction with a related party or an affiliate of a related party, the Audit Committee will review the proposed transaction to determine, based on applicable Nasdaq and SEC rules, if such transaction requires pre-approval by the Audit Committee and/or the Board of Directors. If pre-approval is required, such matters will be reviewed at the next regular or special Audit Committee and/or Board of Directors meeting. We may not enter into a related party transaction unless our Audit Committee has specifically confirmed in writing that either no further reviews are necessary or that all requisite corporate reviews have been obtained.
 
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GENERAL MATTERS
Availability of Certain Documents
A copy of our 2023 Annual Report has been posted on the Company’s website (www.mersana.com) along with this proxy statement. Upon written request, we will mail, without charge, a copy of our 2023 Annual Report, excluding exhibits. Please send a written request to our Secretary at:
Mersana Therapeutics, Inc.
840 Memorial Drive
Cambridge, Massachusetts 02139
Attention: Secretary
Phone: (617) 498-0020
SEC rules concerning the delivery of annual disclosure documents allow us or your broker to send a single notice or, if applicable, a single set of our proxy materials to any household at which two or more of our stockholders reside, if we or your broker believe that the stockholders are members of the same family, unless we have received contrary instructions from one or more of the stockholders. This practice, referred to as “householding,” reduces the volume of duplicate information received at your household and helps to reduce our expenses. The rule applies to our notices, annual reports, proxy statements and information statements.
We will undertake to deliver promptly, upon written or oral request, a separate copy to a stockholder at a shared address to which a single copy of the notice or proxy materials was delivered. You may make a written or oral request by sending a notification to our Secretary at the address or telephone number above, providing your name, your shared address, and the address to which we should direct the additional copy of the notice or proxy materials. Multiple stockholders sharing an address who have received one copy of a mailing and would prefer us to mail each stockholder a separate copy of future mailings should contact us at our principal executive offices. Additionally, if current stockholders with a shared address received multiple copies of a mailing and would prefer us to mail one copy of future mailings to stockholders at the shared address, notification of that request may also be made through our principal executive offices. Stockholders who participate in householding will continue to have access to and utilize separate proxy voting instructions.
Stockholder Proposals and Nominations
Requirements for Stockholder Proposals or Director Nominations to be Brought Before an Annual Meeting.   Our Bylaws provide that, for stockholder nominations to the Board of Directors or other proposals to be considered at an annual meeting, the stockholder must have given timely notice thereof in writing to the Secretary at Mersana Therapeutics, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139. The Nominating and Corporate Governance Committee does not have a written policy regarding stockholder nominations but has determined that it is the practice of such Committee to consider candidates proposed by stockholders if made in accordance with our Bylaws. The specific requirements for the information that is required to be provided for such recommendations to be considered are specified in our Bylaws.
To be timely for the 2025 annual meeting, although not included in the proxy statement, the stockholder’s notice must be delivered to or mailed and received by us not earlier than the close of business on the 120th day nor later than the close of business on the 90th day prior to the anniversary date of the prior year’s annual meeting, except that if the annual meeting is advanced by more than 30 days or delayed by more than 60 days from the first anniversary of the preceding year’s annual meeting, we must receive the notice not earlier than the 120th day prior to such annual meeting and not later than the close of business on the later of (a) the 90th day prior to such annual meeting and (b) the tenth day following the day on which we first provide public disclosure of the date of the meeting. Assuming the date of our 2025 annual meeting is not so advanced or delayed, stockholders who wish to make a proposal at the 2025 annual meeting must notify us no earlier than February 11, 2025 and no later than March 13, 2025. Such notice must provide the information required by our Bylaws with respect to each matter the stockholder proposes to bring before the 2025 annual meeting. Stockholders are advised to review our Bylaws, which specify requirements as to the
 
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form and content of a stockholders’ notice, including the information required by Rule 14a-19 under the Exchange Act. Assuming that biographical and background material has been provided on a timely basis, any recommendations received from stockholders for nominations for directors will be evaluated in the same manner as potential nominees proposed by the Nominating and Corporate Governance Committee. If our Board determines to nominate a stockholder-recommended candidate and recommends his or her election, then his or her name will be included on our proxy card for the next annual meeting.
Requirements for Stockholder Proposals to be Considered for Inclusion in our Proxy Materials.   To be considered for inclusion in next year’s proxy statement, stockholder proposals pursuant to Rule 14a-8 under the Exchange Act must be received by our Secretary at our principal executive offices no later than the close of business on December 27, 2024, which is 120 days prior to the date that is one year from this year’s mailing date of April 26, 2024.
Contacting the Board of Directors
Stockholders wishing to communicate with the Board of Directors may do so by writing to the Board of Directors, the non-employee members of the Board as a group or to any individual director, at:
Mersana Therapeutics, Inc.
840 Memorial Drive
Cambridge, Massachusetts 02139
Attention: Secretary
The communication must prominently display the legend “BOARD COMMUNICATION” in order to indicate to the Secretary that it is a communication for the Board of Directors. Upon receiving such a communication, the Secretary will promptly forward the communication to the relevant individual or group to which it is addressed. Certain items that are unrelated to the Board of Directors’ duties and responsibilities may be excluded. The Secretary will not forward any communication determined in her good faith belief to be frivolous, unduly hostile, threatening, illegal or similarly unsuitable.
Other Matters
As of the date of this proxy statement, the Board of Directors does not intend to present any matters other than those described herein at the Annual Meeting and is unaware of any matters to be presented by other parties. If other matters are properly brought before the meeting for action by the stockholders, proxies will be voted in accordance with the recommendation of the Board of Directors or, in the absence of such a recommendation, in accordance with the judgment of the proxy holder.
 
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MERSANA THERAPEUTICS, INC.840 MEMORIAL DRIVECAMBRIDGE, MA 02139 SCAN TO VIEW MATERIALS & VOTE VOTE BY INTERNETBefore The Meeting - Go to www.proxyvote.com or scan the QR Barcode aboveUse the Internet to transmit your voting instructions and for electronic delivery of informationup until 11:59 p.m. Eastern Time on June 10, 2024. Have your proxy card in hand whenyou access the web site and follow the instructions to obtain your records and to createan electronic voting instruction form.During The Meeting - Go to www.virtualshareholdermeeting.com/MRSN2024You may attend the meeting via the Internet and vote during the meeting. Have theinformation that is printed in the box marked by the arrow available and follow theinstructions.VOTE BY PHONE - 1-800-690-6903Use any touch-tone telephone to transmit your voting instructions up until11:59 p.m. Eastern Time on June 10, 2024. Have your proxy card in hand when you calland then follow the instructions.VOTE BY MAILMark, sign and date your proxy card and return it in the postage-paidenvelope we have provided or return it to Vote Processing, c/o Broadridge,51 Mercedes Way, Edgewood, NY 11717. TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS:KEEP THIS PORTION FOR YOUR RECORDSTHIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. DETACH AND RETURN THIS PORTION ONLY MERSANA THERAPEUTICS, INC.MERSANA THERAPEUTICS, INC.840 MEMORIAL DRIVECAMBRIDGE, MA 021391a. Willard H. Dere, M.D.1b. Martin Huber, M.D.1. Election of Class I Directors, each to serve until the2027 Annual Meeting of StockholdersNominees:The Board of Directors recommends you vote FOR eachof the following nominees:Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor,administrator, or other fiduciary, please give full title as such. Joint owners should each signpersonally. All holders must sign. If a corporation or partnership, please sign in full corporateor partnership name by authorized officer.The Board of Directors recommends you vote FOR the following proposal:NOTE: Such other business as may properly come before the meeting or any adjournment thereof. For Against Abstain For Against Abstain For Against Abstain The Board of Directors recommends you vote FOR the following proposal:2. To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers. The Board of Directors recommends you vote FOR the following proposal: 3. To ratify the selection of Ernst & Young LLP as the Company's independent registered public accounting firm for the fiscal year endingDecember 31, 2024. NOTE: Such other business as may properly come before the meeting or any adjournment thereof.

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Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to Be Heldon June 11, 2024:The Notice of Annual Meeting and Proxy Statement and Annual Report are available at www.proxyvote.com. V45684-P06742 MERSANA THERAPEUTICS, INC.Annual Meeting of StockholdersJune 11, 2024 at 9:00 AM, EDTThis proxy is solicited on behalf of the Board of DirectorsThe stockholder(s) hereby appoint(s) Martin Huber, M.D. and Alejandra Carvajal, or either of them, as proxies, each withthe power to appoint his or her substitute, and hereby authorize(s) them to represent and to vote, as designated on thereverse side of this ballot, all of the shares of common stock of MERSANA THERAPEUTICS, INC. that the stockholder(s)is/are entitled to vote at the Annual Meeting of Stockholders to be held at 9:00 AM, EDT on June 11, 2024, via live webcast atwww.virtualshareholdermeeting.com/MRSN2024, and any adjournment or postponement thereof.In their discretion, the proxies are authorized to vote upon such other business as may properly come before the meeting or anyadjournment or postponement thereof.This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, thisproxy will be voted FOR the election of each nominee under Proposal 1 and FOR Proposals 2 and 3.Continued and to be signed on reverse side