The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   73,543,088 403,861 SH   DFND   0 403,861 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109   21,209,887 267,734 SH   DFND   0 267,734 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   16,468,553 10,423,135 SH   DFND   0 10,423,135 0
ALIGN TECHNOLOGY INC COM 016255101   7,460,508 22,751 SH   DFND   0 22,751 0
ALKERMES PLC SHS G01767105   11,628,541 429,573 SH   DFND   0 429,573 0
APELLIS PHARMACEUTICALS INC COM 03753U106   4,875,919 82,952 SH   DFND   0 82,952 0
ARCELLX INC COMMON STOCK 03940C100   21,088,256 303,210 SH   DFND   0 303,210 0
ARGENX SE SPONSORED ADR 04016X101   34,187,495 86,832 SH   DFND   0 86,832 0
ARK ETF TR INNOVATION ETF 00214Q104   12,132,381 242,260 SH   DFND   0 242,260 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   6,933,239 6,000,000 PRN   DFND   0 6,000,000 0
ASTRIA THERAPEUTICS INC COM 04635X102   4,603,158 327,045 SH   DFND   0 327,045 0
AVANTOR INC COM 05352A100   34,348,411 1,343,309 SH   DFND   0 1,343,309 0
AXSOME THERAPEUTICS INC COM 05464T104   37,300,675 467,427 SH   DFND   0 467,427 0
BECTON DICKINSON & CO COM 075887109   42,450,542 171,552 SH   DFND   0 171,552 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4   14,766,000 15,000,000 PRN   DFND   0 15,000,000 0
BLUEBIRD BIO INC COM 09609G100   2,614,593 2,042,651 SH   DFND   0 2,042,651 0
BOSTON SCIENTIFIC CORP COM 101137107   11,834,113 172,786 SH   DFND   0 172,786 0
BOUNDLESS BIO INC COM 10170A100   2,002,310 140,513 SH   DFND   0 140,513 0
CARIBOU BIOSCIENCES INC COM 142038108   33,324,008 6,483,270 SH   DFND   0 6,483,270 0
CELCUITY INC COM 15102K100   10,735,243 497,002 SH   DFND   0 497,002 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   1,468,950 35,000 SH   DFND   0 35,000 0
CENTENE CORP DEL COM 15135B101   46,971,300 598,513 SH   DFND   0 598,513 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   3,555,816 314,674 SH   DFND   0 314,674 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   9,065,405 1,089,592 SH   DFND   0 1,089,592 0
CULLINAN ONCOLOGY INC COM 230031106   4,361,678 255,967 SH   DFND   0 255,967 0
CYTOKINETICS INC COM NEW 23282W605   123,196,731 1,757,192 SH   DFND   0 1,757,192 0
CYTOKINETICS INC NOTE 3.500% 7/0 23282WAC4   11,448,000 7,200,000 PRN   DFND   0 7,200,000 0
DANAHER CORPORATION COM 235851102   31,343,606 125,515 SH   DFND   0 125,515 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   5,868,747 355,251 SH   DFND   0 355,251 0
DEXCOM INC COM 252131107   21,620,279 155,878 SH   DFND   0 155,878 0
EDWARDS LIFESCIENCES CORP COM 28176E108   70,739,246 740,260 SH   DFND   0 740,260 0
ELEVANCE HEALTH INC COM 036752103   28,649,335 55,250 SH   DFND   0 55,250 0
ELI LILLY & CO COM 532457108   232,332,308 298,643 SH   DFND   0 298,643 0
ERASCA INC COM 29479A108   5,222,310 2,535,102 SH   DFND   0 2,535,102 0
ESSA PHARMA INC COM NEW 29668H708   25,303,766 2,980,420 SH   DFND   0 2,980,420 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   3,531,904 170,871 SH   DFND   0 170,871 0
GENERATION BIO CO COM 37148K100   6,603,522 1,622,487 SH   DFND   0 1,622,487 0
HCA HEALTHCARE INC COM 40412C101   23,947,454 71,800 SH Call DFND   0 71,800 0
HCA HEALTHCARE INC COM 40412C101   41,637,885 124,840 SH   DFND   0 124,840 0
HUMANA INC COM 444859102   43,457,885 125,340 SH   DFND   0 125,340 0
ICON PLC SHS G4705A100   38,878,150 115,726 SH   DFND   0 115,726 0
IMMUNOVANT INC COM 45258J102   15,267,767 472,540 SH   DFND   0 472,540 0
INHIBRX INC COM 45720L107   1,675,213 47,918 SH   DFND   0 47,918 0
INSPIRE MED SYS INC COM 457730109   7,207,708 33,557 SH   DFND   0 33,557 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   6,842,427 98,879 SH   DFND   0 98,879 0
INTUITIVE SURGICAL INC COM NEW 46120E602   44,313,756 111,037 SH   DFND   0 111,037 0
IO BIOTECH INC COM 449778109   4,050,115 2,341,107 SH   DFND   0 2,341,107 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   4,605,374 310,754 SH   DFND   0 310,754 0
IQVIA HLDGS INC COM 46266C105   28,286,758 111,854 SH   DFND   0 111,854 0
ISHARES TR CHINA LG-CAP ETF 464287184   3,396,807 141,122 SH   DFND   0 141,122 0
ISHARES TR RUSSELL 2000 ETF 464287655   20,843,885 99,115 SH   DFND   0 99,115 0
ISHARES TR 2 CHINA LG-CAP ETF 464287184   24,618,796 1,022,800 SH Call DFND   0 1,022,800 0
ISHARES TR 3 RUSSELL 2000 ETF 464287655   18,632,580 88,600 SH Call DFND   0 88,600 0
ISHARES TR 4 20 YR TR BD ETF 464287432   49,486,260 523,000 SH Put DFND   0 523,000 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   41,186,494 734,293 SH   DFND   0 734,293 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   8,003,990 29,973 SH   DFND   0 29,973 0
MCKESSON CORP COM 58155Q103   52,341,801 97,498 SH   DFND   0 97,498 0
MERCK & CO INC COM 58933Y105   78,676,639 596,261 SH   DFND   0 596,261 0
METAGENOMI INC COM 59102M104   13,366,871 1,267,002 SH   DFND   0 1,267,002 0
MOLINA HEALTHCARE INC COM 60855R100   28,794,253 70,088 SH   DFND   0 70,088 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7   16,581,250 17,500,000 PRN   DFND   0 17,500,000 0
OSCAR HEALTH INC CL A 687793109   12,800,408 860,821 SH   DFND   0 860,821 0
OUTSET MED INC COM 690145107   2,593,038 1,168,035 SH   DFND   0 1,168,035 0
PENUMBRA INC COM 70975L107   34,768,319 155,786 SH   DFND   0 155,786 0
PMV PHARMACEUTICALS INC COM 69353Y103   2,168,285 1,275,462 SH   DFND   0 1,275,462 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207   29,143,457 477,605 SH   DFND   0 477,605 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   4,350,699 802,712 SH   DFND   0 802,712 0
SANA BIOTECHNOLOGY INC COM 799566104   6,750,000 675,000 SH   DFND   0 675,000 0
SAREPTA THERAPEUTICS INC COM 803607100   1,461,733 11,291 SH   DFND   0 11,291 0
SILK RD MED INC COM 82710M100   6,065,092 331,064 SH   DFND   0 331,064 0
STRYKER CORPORATION COM 863667101   19,715,774 55,092 SH   DFND   0 55,092 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   15,676,917 658,694 SH   DFND   0 658,694 0
TENAYA THERAPEUTICS INC COM 87990A106   1,162,221 222,222 SH   DFND   0 222,222 0
TENET HEALTHCARE CORP COM NEW 88033G407   61,952,780 589,409 SH   DFND   0 589,409 0
THERMO FISHER SCIENTIFIC INC COM 883556102   33,732,266 58,038 SH   DFND   0 58,038 0
TURNSTONE BIOLOGICS CORP COM 90042W100   2,412,957 920,976 SH   DFND   0 920,976 0
UNIQURE NV SHS N90064101   1,427,608 274,540 SH   DFND   0 274,540 0
UNITEDHEALTH GROUP INC COM 91324P102   9,577,887 19,361 SH   DFND   0 19,361 0
UNIVERSAL HLTH SVCS INC CL B 913903100   39,043,338 213,983 SH   DFND   0 213,983 0
VEEVA SYS INC CL A COM 922475108   27,549,099 118,905 SH   DFND   0 118,905 0
VERTEX PHARMACEUTICALS INC COM 92532F100   62,221,625 148,852 SH   DFND   0 148,852 0
VIKING THERAPEUTICS INC COM 92686J106   2,691,814 32,827 SH   DFND   0 32,827 0
WATERS CORP COM 941848103   13,240,463 38,464 SH   DFND   0 38,464 0
WEREWOLF THERAPEUTICS INC COM 95075A107   19,483,636 3,006,734 SH   DFND   0 3,006,734 0
WEST PHARMACEUTICAL SVSC INC COM 955306105   20,259,165 51,197 SH   DFND   0 51,197 0
XENON PHARMACEUTICALS INC COM 98420N105   6,481,350 150,554 SH   DFND   0 150,554 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   39,640,325 300,351 SH   DFND   0 300,351 0