The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 73,543,088 | 403,861 | SH | DFND | 0 | 403,861 | 0 | |||
ACADIA HEALTHCARE COMPANY IN | COM | 00404A109 | 21,209,887 | 267,734 | SH | DFND | 0 | 267,734 | 0 | |||
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 16,468,553 | 10,423,135 | SH | DFND | 0 | 10,423,135 | 0 | |||
ALIGN TECHNOLOGY INC | COM | 016255101 | 7,460,508 | 22,751 | SH | DFND | 0 | 22,751 | 0 | |||
ALKERMES PLC | SHS | G01767105 | 11,628,541 | 429,573 | SH | DFND | 0 | 429,573 | 0 | |||
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 4,875,919 | 82,952 | SH | DFND | 0 | 82,952 | 0 | |||
ARCELLX INC | COMMON STOCK | 03940C100 | 21,088,256 | 303,210 | SH | DFND | 0 | 303,210 | 0 | |||
ARGENX SE | SPONSORED ADR | 04016X101 | 34,187,495 | 86,832 | SH | DFND | 0 | 86,832 | 0 | |||
ARK ETF TR | INNOVATION ETF | 00214Q104 | 12,132,381 | 242,260 | SH | DFND | 0 | 242,260 | 0 | |||
ASCENDIS PHARMA A/S | NOTE 2.250% 4/0 | 04351PAD3 | 6,933,239 | 6,000,000 | PRN | DFND | 0 | 6,000,000 | 0 | |||
ASTRIA THERAPEUTICS INC | COM | 04635X102 | 4,603,158 | 327,045 | SH | DFND | 0 | 327,045 | 0 | |||
AVANTOR INC | COM | 05352A100 | 34,348,411 | 1,343,309 | SH | DFND | 0 | 1,343,309 | 0 | |||
AXSOME THERAPEUTICS INC | COM | 05464T104 | 37,300,675 | 467,427 | SH | DFND | 0 | 467,427 | 0 | |||
BECTON DICKINSON & CO | COM | 075887109 | 42,450,542 | 171,552 | SH | DFND | 0 | 171,552 | 0 | |||
BIOMARIN PHARMACEUTICAL INC | NOTE 0.599% 8/0 | 09061GAH4 | 14,766,000 | 15,000,000 | PRN | DFND | 0 | 15,000,000 | 0 | |||
BLUEBIRD BIO INC | COM | 09609G100 | 2,614,593 | 2,042,651 | SH | DFND | 0 | 2,042,651 | 0 | |||
BOSTON SCIENTIFIC CORP | COM | 101137107 | 11,834,113 | 172,786 | SH | DFND | 0 | 172,786 | 0 | |||
BOUNDLESS BIO INC | COM | 10170A100 | 2,002,310 | 140,513 | SH | DFND | 0 | 140,513 | 0 | |||
CARIBOU BIOSCIENCES INC | COM | 142038108 | 33,324,008 | 6,483,270 | SH | DFND | 0 | 6,483,270 | 0 | |||
CELCUITY INC | COM | 15102K100 | 10,735,243 | 497,002 | SH | DFND | 0 | 497,002 | 0 | |||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 1,468,950 | 35,000 | SH | DFND | 0 | 35,000 | 0 | |||
CENTENE CORP DEL | COM | 15135B101 | 46,971,300 | 598,513 | SH | DFND | 0 | 598,513 | 0 | |||
CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 3,555,816 | 314,674 | SH | DFND | 0 | 314,674 | 0 | |||
COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 9,065,405 | 1,089,592 | SH | DFND | 0 | 1,089,592 | 0 | |||
CULLINAN ONCOLOGY INC | COM | 230031106 | 4,361,678 | 255,967 | SH | DFND | 0 | 255,967 | 0 | |||
CYTOKINETICS INC | COM NEW | 23282W605 | 123,196,731 | 1,757,192 | SH | DFND | 0 | 1,757,192 | 0 | |||
CYTOKINETICS INC | NOTE 3.500% 7/0 | 23282WAC4 | 11,448,000 | 7,200,000 | PRN | DFND | 0 | 7,200,000 | 0 | |||
DANAHER CORPORATION | COM | 235851102 | 31,343,606 | 125,515 | SH | DFND | 0 | 125,515 | 0 | |||
DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 5,868,747 | 355,251 | SH | DFND | 0 | 355,251 | 0 | |||
DEXCOM INC | COM | 252131107 | 21,620,279 | 155,878 | SH | DFND | 0 | 155,878 | 0 | |||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 70,739,246 | 740,260 | SH | DFND | 0 | 740,260 | 0 | |||
ELEVANCE HEALTH INC | COM | 036752103 | 28,649,335 | 55,250 | SH | DFND | 0 | 55,250 | 0 | |||
ELI LILLY & CO | COM | 532457108 | 232,332,308 | 298,643 | SH | DFND | 0 | 298,643 | 0 | |||
ERASCA INC | COM | 29479A108 | 5,222,310 | 2,535,102 | SH | DFND | 0 | 2,535,102 | 0 | |||
ESSA PHARMA INC | COM NEW | 29668H708 | 25,303,766 | 2,980,420 | SH | DFND | 0 | 2,980,420 | 0 | |||
EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 3,531,904 | 170,871 | SH | DFND | 0 | 170,871 | 0 | |||
GENERATION BIO CO | COM | 37148K100 | 6,603,522 | 1,622,487 | SH | DFND | 0 | 1,622,487 | 0 | |||
HCA HEALTHCARE INC | COM | 40412C101 | 23,947,454 | 71,800 | SH | Call | DFND | 0 | 71,800 | 0 | ||
HCA HEALTHCARE INC | COM | 40412C101 | 41,637,885 | 124,840 | SH | DFND | 0 | 124,840 | 0 | |||
HUMANA INC | COM | 444859102 | 43,457,885 | 125,340 | SH | DFND | 0 | 125,340 | 0 | |||
ICON PLC | SHS | G4705A100 | 38,878,150 | 115,726 | SH | DFND | 0 | 115,726 | 0 | |||
IMMUNOVANT INC | COM | 45258J102 | 15,267,767 | 472,540 | SH | DFND | 0 | 472,540 | 0 | |||
INHIBRX INC | COM | 45720L107 | 1,675,213 | 47,918 | SH | DFND | 0 | 47,918 | 0 | |||
INSPIRE MED SYS INC | COM | 457730109 | 7,207,708 | 33,557 | SH | DFND | 0 | 33,557 | 0 | |||
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 6,842,427 | 98,879 | SH | DFND | 0 | 98,879 | 0 | |||
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 44,313,756 | 111,037 | SH | DFND | 0 | 111,037 | 0 | |||
IO BIOTECH INC | COM | 449778109 | 4,050,115 | 2,341,107 | SH | DFND | 0 | 2,341,107 | 0 | |||
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 4,605,374 | 310,754 | SH | DFND | 0 | 310,754 | 0 | |||
IQVIA HLDGS INC | COM | 46266C105 | 28,286,758 | 111,854 | SH | DFND | 0 | 111,854 | 0 | |||
ISHARES TR | CHINA LG-CAP ETF | 464287184 | 3,396,807 | 141,122 | SH | DFND | 0 | 141,122 | 0 | |||
ISHARES TR | RUSSELL 2000 ETF | 464287655 | 20,843,885 | 99,115 | SH | DFND | 0 | 99,115 | 0 | |||
ISHARES TR 2 | CHINA LG-CAP ETF | 464287184 | 24,618,796 | 1,022,800 | SH | Call | DFND | 0 | 1,022,800 | 0 | ||
ISHARES TR 3 | RUSSELL 2000 ETF | 464287655 | 18,632,580 | 88,600 | SH | Call | DFND | 0 | 88,600 | 0 | ||
ISHARES TR 4 | 20 YR TR BD ETF | 464287432 | 49,486,260 | 523,000 | SH | Put | DFND | 0 | 523,000 | 0 | ||
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 41,186,494 | 734,293 | SH | DFND | 0 | 734,293 | 0 | |||
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 8,003,990 | 29,973 | SH | DFND | 0 | 29,973 | 0 | |||
MCKESSON CORP | COM | 58155Q103 | 52,341,801 | 97,498 | SH | DFND | 0 | 97,498 | 0 | |||
MERCK & CO INC | COM | 58933Y105 | 78,676,639 | 596,261 | SH | DFND | 0 | 596,261 | 0 | |||
METAGENOMI INC | COM | 59102M104 | 13,366,871 | 1,267,002 | SH | DFND | 0 | 1,267,002 | 0 | |||
MOLINA HEALTHCARE INC | COM | 60855R100 | 28,794,253 | 70,088 | SH | DFND | 0 | 70,088 | 0 | |||
NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 16,581,250 | 17,500,000 | PRN | DFND | 0 | 17,500,000 | 0 | |||
OSCAR HEALTH INC | CL A | 687793109 | 12,800,408 | 860,821 | SH | DFND | 0 | 860,821 | 0 | |||
OUTSET MED INC | COM | 690145107 | 2,593,038 | 1,168,035 | SH | DFND | 0 | 1,168,035 | 0 | |||
PENUMBRA INC | COM | 70975L107 | 34,768,319 | 155,786 | SH | DFND | 0 | 155,786 | 0 | |||
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 2,168,285 | 1,275,462 | SH | DFND | 0 | 1,275,462 | 0 | |||
PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | 29,143,457 | 477,605 | SH | DFND | 0 | 477,605 | 0 | |||
SAGIMET BIOSCIENCES INC | COM SER A | 786700104 | 4,350,699 | 802,712 | SH | DFND | 0 | 802,712 | 0 | |||
SANA BIOTECHNOLOGY INC | COM | 799566104 | 6,750,000 | 675,000 | SH | DFND | 0 | 675,000 | 0 | |||
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,461,733 | 11,291 | SH | DFND | 0 | 11,291 | 0 | |||
SILK RD MED INC | COM | 82710M100 | 6,065,092 | 331,064 | SH | DFND | 0 | 331,064 | 0 | |||
STRYKER CORPORATION | COM | 863667101 | 19,715,774 | 55,092 | SH | DFND | 0 | 55,092 | 0 | |||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 15,676,917 | 658,694 | SH | DFND | 0 | 658,694 | 0 | |||
TENAYA THERAPEUTICS INC | COM | 87990A106 | 1,162,221 | 222,222 | SH | DFND | 0 | 222,222 | 0 | |||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 61,952,780 | 589,409 | SH | DFND | 0 | 589,409 | 0 | |||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 33,732,266 | 58,038 | SH | DFND | 0 | 58,038 | 0 | |||
TURNSTONE BIOLOGICS CORP | COM | 90042W100 | 2,412,957 | 920,976 | SH | DFND | 0 | 920,976 | 0 | |||
UNIQURE NV | SHS | N90064101 | 1,427,608 | 274,540 | SH | DFND | 0 | 274,540 | 0 | |||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 9,577,887 | 19,361 | SH | DFND | 0 | 19,361 | 0 | |||
UNIVERSAL HLTH SVCS INC | CL B | 913903100 | 39,043,338 | 213,983 | SH | DFND | 0 | 213,983 | 0 | |||
VEEVA SYS INC | CL A COM | 922475108 | 27,549,099 | 118,905 | SH | DFND | 0 | 118,905 | 0 | |||
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 62,221,625 | 148,852 | SH | DFND | 0 | 148,852 | 0 | |||
VIKING THERAPEUTICS INC | COM | 92686J106 | 2,691,814 | 32,827 | SH | DFND | 0 | 32,827 | 0 | |||
WATERS CORP | COM | 941848103 | 13,240,463 | 38,464 | SH | DFND | 0 | 38,464 | 0 | |||
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 19,483,636 | 3,006,734 | SH | DFND | 0 | 3,006,734 | 0 | |||
WEST PHARMACEUTICAL SVSC INC | COM | 955306105 | 20,259,165 | 51,197 | SH | DFND | 0 | 51,197 | 0 | |||
XENON PHARMACEUTICALS INC | COM | 98420N105 | 6,481,350 | 150,554 | SH | DFND | 0 | 150,554 | 0 | |||
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 39,640,325 | 300,351 | SH | DFND | 0 | 300,351 | 0 |