Discontinued Operations - Summary of Gain on Sale of Discontinued Operations (Details) - USD ($) $ in Thousands		12 Months Ended
	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration]		Less: Net income from discontinued operations
Agios Oncology Business | Discontinued Operations, Disposed of by Sale
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Cash proceeds	$ 1,800,000	$ 1,802,936
Less: transaction and insurance costs		(53,573)
Plus: net liabilities distributed, including working capital adjustment	$ 243,188	239,770
Gain on sale, pre-tax		1,989,133	$ 0
Income tax expense		(12,799)	$ 0
Gain on sale, net of tax		$ 1,976,334