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Overview and Basis of Presentation (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended
Oct. 27, 2022
Apr. 05, 2021
Mar. 31, 2021
Sep. 30, 2022
Sep. 30, 2021
Jun. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Apr. 02, 2021
Mar. 25, 2021
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Royalty income from gain on sale of oncology business       $ 4,443 $ 1,996   $ 9,851 $ 3,996    
Stock repurchase program, authorized amount                   $ 1,200,000
Repurchase of common stock         $ 254,391 $ 529,047        
Cash, cash equivalents, and marketable securities       $ 1,000,000     $ 1,000,000      
Subsequent Event | Licensing Agreements                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Proceeds from sale of royalties $ 131,800                  
BMS Repurchase                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Repurchase of common stock (in shares)   7,100,000                
Repurchase of common stock   $ 344,500                
Shares repurchased (in usd per share)   $ 48.38                
Rule 10b5-1 repurchase plan                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Stock repurchase program, authorized amount                 $ 600,000  
Repurchase of common stock (in shares)             9,100,000      
Repurchase of common stock             $ 458,000      
Shares repurchased (in usd per share)             $ 50.35      
Rule 10b-18 repurchase program                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Repurchase of common stock (in shares)             0      
Repurchase Program                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Repurchase of common stock (in shares)             16,200,000      
Repurchase of common stock             $ 802,500      
Shares repurchased (in usd per share)             $ 49.49      
2010 Agreement                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Milestone payment for achievement of specified ex-U.S. commercial milestone event     $ 25,000              
Discontinued Operations, Disposed of by Sale | Agios Oncology Business                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Cash proceeds     1,800,000              
Contingent milestone payment     $ 200,000              
Discontinued Operations, Disposed of by Sale | Agios Oncology Business | TIBSOVO | UNITED STATES                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Contingent royalty payment     5.00%              
Discontinued Operations, Disposed of by Sale | Agios Oncology Business | Vorasidenib | UNITED STATES                    
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]                    
Contingent royalty payment     15.00%