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Share-Based Payments (Tables)
 6 Months Ended
Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Company's Stock Option Activity The following table presents stock option activity for the six months ended June 30, 2022:
Number of
Stock Options
Weighted-Average
Exercise Price
Outstanding at December 31, 20214,798,826 $58.51 
Granted1,043,418 29.08 
Exercised(4,074)7.56 
Forfeited/Expired(463,999)68.38 
Outstanding at June 30, 20225,374,171 $52.00 
Exercisable at June 30, 20223,473,922 $58.44 
Vested and expected to vest at June 30, 20225,374,171 $52.00 
Unvested Stock Unit Activity The following table presents RSU activity for the six months ended June 30, 2022:
Number of
Stock Units
Weighted-Average
Grant Date Fair 
Value
Unvested shares at December 31, 20211,002,924 $51.51 
Granted736,813 31.70 
Vested(375,154)53.95 
Forfeited(124,097)41.48 
Unvested shares at June 30, 20221,240,486 $40.06 
Schedule of Performance-Based Units The following table presents PSU activity for the six months ended June 30, 2022:
Number of
Stock Units
Weighted-Average
Grant Date Fair 
Value
Unvested shares at December 31, 2021234,059 $54.28 
Granted156,300 31.53 
Vested(53,777)54.28 
Forfeited(5,168)61.93 
Unvested shares at June 30, 2022331,414 $43.43 
Schedule of Market-Based Units Activity The following table presents market-based stock unit, or MSU, activity for the six months ended June 30, 2022:
Number of
Stock Units		Weighted-Average
Grant Date Fair
Value
Unvested shares at December 31, 202142,695 $41.50 
Granted— — 
Unvested shares at June 30, 202242,695 $41.50 
Schedule of Stock-Based Compensation Expense by Award Type Included Within the Condensed Consolidated Statements of Operations
Stock-based compensation expense by award type included within the condensed consolidated statements of operations is as follows:
Three Months Ended
June 30,		Six Months Ended
June 30,
(In thousands)2022202120222021
Stock options$5,655 $8,789 $11,856 $17,185 
Restricted stock units5,232 5,784 11,397 11,989 
Performance-based stock units— — 2,919 — 
Employee stock purchase plan278 312 503 565 
Total stock-based compensation expense$11,165 $14,885 $26,675 $29,739 
Schedule of Allocated Stock-Based Compensation Expense Expenses related to stock options and stock-based awards were allocated as follows in the condensed consolidated statements of operations:
Three Months Ended
June 30,		Six Months Ended
June 30,
(In thousands)2022202120222021
Research and development expense$4,923 $6,422 $11,579 $13,395 
Selling, general and administrative expense6,242 8,463 15,096 16,344 
Total stock-based compensation expense$11,165 $14,885 $26,675 $29,739