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Selected Quarterly Financial Data (Unaudited) - Summary of Quarterly Financial Data (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]                      
Total revenue $ 30,013 $ 15,198 $ 40,414 $ 8,762 $ 9,799 $ 11,358 $ 11,346 $ 10,508      
Loss from operations (96,356) (99,162) (72,949) (94,012) (90,130) (79,017) (84,600) (67,047) $ (362,479) $ (320,794) $ (200,985)
Net loss $ (91,794) $ (94,664) $ (68,745) $ (90,825) $ (88,285) $ (77,137) $ (83,082) $ (66,166)      
Net loss per share - basic and diluted (in usd per share) $ (1.58) $ (1.63) $ (1.19) $ (1.63) $ (1.81) $ (1.59) $ (1.78) $ (1.56) $ (6.03) $ (6.75) $ (5.07)