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Net Loss per Share (Tables)
 12 Months Ended
Dec. 31, 2018
Earnings Per Share [Abstract]  
Common Stock Excluded from Calculation of Diluted Earnings Per Share
The following common stock equivalents were excluded from the calculation of diluted net loss per share applicable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect:
Years ended December 31,
201820172016
Stock options5,416,069 5,577,562 5,218,880 
Restricted stock units532,144 125,584 77,050 
Performance-based stock units169,031 — — 
Employee Stock Purchase Plan shares32,304 22,062 24,018 
6,149,548 5,725,208 5,319,948