Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenues	$ 15,198	$ 11,358	$ 64,374	$ 33,212
Costs and expenses:
Cost of sales	695	0	695	0
Research and development (net of $1,078 and $6,343 of cost reimbursement from related party for the three and nine months ended September 30, 2017)	82,561	72,917	247,515	215,465
Sales, general and administrative	31,104	17,458	82,287	48,411
Total costs and expenses	114,360	90,375	330,497	263,876
Loss from operations	(99,162)	(79,017)	(266,123)	(230,664)
Interest income	4,498	1,880	11,889	4,279
Net loss	$ (94,664)	$ (77,137)	$ (254,234)	$ (226,385)
Net loss per share – basic and diluted (usd per share)	$ (1.63)	$ (1.59)	$ (4.45)	$ (4.94)
Weighted-average number of common shares used in computing net loss per share – basic and diluted (in shares)	58,033,386	48,459,424	57,158,492	45,851,203
Product revenue, net
Revenues:
Revenues	$ 4,465	$ 0	$ 4,465	$ 0
Collaboration revenue - related party
Revenues:
Revenues	8,732	10,643	42,478	32,497
Collaboration revenue - other
Revenues:
Revenues	0	0	12,440	0
Royalty revenue - related party
Revenues:
Revenues	$ 2,001	$ 715	$ 4,991	$ 715

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

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