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Condensed Consolidated Statements of Operations (Parenthetical) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Income Statement [Abstract]        
Reduction of research and development expenses $ 0 $ 2,489,000 $ 0 $ 5,265,000