CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Total revenue	$ 145,238	$ 109,460	$ 131,836
Operating expenses:
Cost of goods sold	11,450	4,420	3,818
Research and development	244,990	227,333	201,159
Selling, general and administrative	265,542	197,520	126,284
Restructuring	11,394	0	0
Total operating expenses	533,376	429,273	331,261
Operating loss	(388,138)	(319,813)	(199,425)
Other income (expenses), net:
Interest income	21,768	6,276	1,993
Interest expense	(11,334)	(11,014)	(19,682)
Other income, net	1,594	974	231
Loss on extinguishment of debt	0	(7,578)	0
Total other income (expense), net	12,028	(11,342)	(17,458)
Loss from continuing operations before income tax provision	(376,110)	(331,155)	(216,883)
Income tax provision on continuing operations	(223)	(313)	(409)
Loss from continuing operations, net of tax	(376,333)	(331,468)	(217,292)
Income from discontinued operations, net of tax	264,934	52,986	37,201
Net loss	$ (111,399)	$ (278,482)	$ (180,091)
Basic and diluted:
Net loss from continuing operations, basic (in dollars per share)	$ (5.07)	$ (5.20)	$ (3.63)
Net loss from continuing operations, diluted (in dollars per share)	(5.07)	(5.20)	(3.63)
Net income from discontinued operations, basic (in dollars per share)	3.57	0.83	0.62
Net income from discontinued operations, diluted (in dollars per share)	3.57	0.83	0.62
Net income (loss) per common share, basic (in dollars per share)	(1.50)	(4.37)	(3.01)
Net income (loss) per common share, diluted (in dollars per share)	$ (1.50)	$ (4.37)	$ (3.01)
Weighted average common shares outstanding, basic (in shares)	74,267,418	63,758,515	59,832,287
Weighted average common shares outstanding, diluted (in shares)	74,267,418	63,758,515	59,832,287
Comprehensive loss:
Net loss	$ (111,399)	$ (278,482)	$ (180,091)
Unrealized loss on defined benefit pension plan	(374)	(368)	0
Foreign currency translation (loss) gain	(1,871)	507	1,515
Unrealized gain (loss) on marketable debt securities	3,696	(2,484)	(1,175)
Comprehensive loss	(109,948)	(280,827)	(179,751)
Net product sales
Total revenue	127,537	97,970	115,122
Operating expenses:
Cost of goods sold	8,406	4,420	3,818
License and collaboration revenue
Total revenue	17,701	11,490	16,714
Operating expenses:
Cost of goods sold	$ 3,044	$ 0	$ 0