CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Total revenue	$ 212,018	$ 227,490	$ 198,321
Operating expenses:
Cost of goods sold	7,592	6,784	6,126
Research and development	235,780	210,328	131,773
Selling, general and administrative	220,206	149,883	135,799
Change in fair value of contingent consideration	15,006	22,260	3,655
Acquired IPR&D expense	0	0	97,131
Total operating expenses	478,584	389,255	374,484
Operating loss	(266,566)	(161,765)	(176,163)
Other income (expenses), net:
Interest income	6,276	1,993	5,003
Interest expense	(11,275)	(20,141)	(19,050)
Other income, net	974	231	1,420
Loss on extinguishment of debt	(7,578)	0	0
Total other expense, net	(11,603)	(17,917)	(12,627)
Loss before income tax (provision) benefit	(278,169)	(179,682)	(188,790)
Income tax (provision) benefit	(313)	(409)	19,359
Net loss	$ (278,482)	$ (180,091)	$ (169,431)
Basic net loss per common share (in dollars per share)	$ (4.37)	$ (3.01)	$ (3.56)
Diluted net loss per common share (in dollars per share)	$ (4.37)	$ (3.01)	$ (3.56)
Basic weighted average common shares outstanding (in shares)	63,758,515	59,832,287	47,539,631
Diluted weighted average common shares outstanding (in shares)	63,758,515	59,832,287	47,539,631
Comprehensive loss:
Net loss	$ (278,482)	$ (180,091)	$ (169,431)
Unrealized loss on defined benefit pension plan	(368)	0	0
Foreign currency translation gain (loss)	507	1,515	(1,452)
Unrealized loss on marketable debt securities	(2,484)	(1,175)	(176)
Comprehensive loss	(280,827)	(179,751)	(171,059)
Net product sales
Total revenue	200,528	210,776	198,321
License and collaboration revenue
Total revenue	$ 11,490	$ 16,714	$ 0