CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Underwritten Equity Offering	At-The-Market Offering	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Common Stock Underwritten Equity Offering	Common Stock At-The-Market Offering	Additional Paid in Capital	Additional Paid in Capital Underwritten Equity Offering	Additional Paid in Capital At-The-Market Offering	Additional Paid in Capital Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
Beginning balance (in shares) at Dec. 31, 2020					52,248,431
Beginning balance at Dec. 31, 2020	$ 211,213				$ 5			$ 797,985				$ (902)	$ (585,875)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share based compensation	14,767							14,767
Issuance of common stock under the equity incentive plan and proceeds from exercise (in shares)					646,872
Issuance of common stock under the equity incentive plan and proceeds from exercise	3,074							3,074
Employee stock purchase program purchase and expense (in shares)					98,887
Employee stock purchase program purchase and expense	1,710							1,710
Issuance of common stock, net of offering costs (in shares)						7,532,500	184,186
Issuance of common stock, net of offering costs		$ 189,279	$ 4,878			$ 1			$ 189,278	$ 4,878
Foreign currency translation adjustments	875											875
Unrealized loss on marketable debt securities	(614)											(614)
Net loss	(92,879)												(92,879)
Ending balance (in shares) at Jun. 30, 2021					60,710,876
Ending balance at Jun. 30, 2021	$ 332,303				$ 6			1,011,692				(641)	(678,754)
Accounting Standards Update [Extensible List]	Accounting Standards Update 2020-06 Cumulative Effect, Period of Adoption [Member]
Beginning balance (in shares) at Dec. 31, 2020					52,248,431
Beginning balance at Dec. 31, 2020	$ 211,213				$ 5			797,985				(902)	(585,875)
Ending balance (in shares) at Dec. 31, 2021					62,491,498
Ending balance at Dec. 31, 2021	302,112			$ (44,720)	$ 6			1,068,634			$ (74,945)	(562)	(765,966)	$ 30,225
Beginning balance (in shares) at Mar. 31, 2021					60,435,730
Beginning balance at Mar. 31, 2021	362,689				$ 6			1,002,687				(262)	(639,742)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share based compensation	7,288							7,288
Issuance of common stock under the equity incentive plan and proceeds from exercise (in shares)					176,259
Issuance of common stock under the equity incentive plan and proceeds from exercise	319							319
Employee stock purchase program purchase and expense (in shares)					98,887
Employee stock purchase program purchase and expense	1,496							1,496
Foreign currency translation adjustments	(227)											(227)
Unrealized loss on marketable debt securities	(152)											(152)
Other	(98)							(98)
Net loss	(39,012)												(39,012)
Ending balance (in shares) at Jun. 30, 2021					60,710,876
Ending balance at Jun. 30, 2021	332,303				$ 6			1,011,692				(641)	(678,754)
Beginning balance (in shares) at Dec. 31, 2021					62,491,498
Beginning balance at Dec. 31, 2021	302,112			$ (44,720)	$ 6			1,068,634			$ (74,945)	(562)	(765,966)	$ 30,225
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share based compensation	20,287							20,287
Issuance of common stock under the equity incentive plan and proceeds from exercise (in shares)					567,777
Issuance of common stock under the equity incentive plan and proceeds from exercise	947							947
Employee stock purchase program purchase and expense (in shares)					77,175
Employee stock purchase program purchase and expense	2,065							2,065
Issuance of common stock, net of offering costs (in shares)							701,600
Issuance of common stock, net of offering costs			$ 19,545							$ 19,545
Foreign currency translation adjustments	1,487											1,487
Unrealized loss on marketable debt securities	(2,007)											(2,007)
Net loss	(143,003)												(143,003)
Ending balance (in shares) at Jun. 30, 2022					63,838,050
Ending balance at Jun. 30, 2022	156,713				$ 6			1,036,533				(1,082)	(878,744)
Beginning balance (in shares) at Mar. 31, 2022					63,510,277
Beginning balance at Mar. 31, 2022	208,141				$ 6			1,021,542				(1,695)	(811,712)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share based compensation	12,352							12,352
Issuance of common stock under the equity incentive plan and proceeds from exercise (in shares)					250,598
Issuance of common stock under the equity incentive plan and proceeds from exercise	824							824
Employee stock purchase program purchase and expense (in shares)					77,175
Employee stock purchase program purchase and expense	1,815							1,815
Foreign currency translation adjustments	1,416											1,416
Unrealized loss on marketable debt securities	(803)											(803)
Net loss	(67,032)												(67,032)
Ending balance (in shares) at Jun. 30, 2022					63,838,050
Ending balance at Jun. 30, 2022	$ 156,713				$ 6			$ 1,036,533				$ (1,082)	$ (878,744)