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SHARE-BASED COMPENSATION
 6 Months Ended
Jun. 30, 2022
Equity [Abstract]  
SHARE-BASED COMPENSATION SHARE-BASED COMPENSATION
Stock Options
The following table summarizes stock option activity during the six months ended June 30, 2022:
 Shares Underlying OptionsWeighted Average Exercise PriceWeighted Average Remaining Contractual Life (years)Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 20218,886,284 $20.26 6.27$96,577 
Granted1,543,270 27.33
Exercised(76,053)12.45
Forfeited/canceled(101,296)24.11
Outstanding at June 30, 202210,252,205 $21.34 6.29$53,798 
At June 30, 2022, unamortized stock compensation for stock options was $39.7 million, with a weighted-average recognition period of 2.8 years.
At June 30, 2022, outstanding options to purchase 6.8 million shares of common stock were exercisable with a weighted-average exercise price per share of $19.87.
Restricted Stock Units
Service Based Restricted Stock Units
The following table summarizes the Company’s service based restricted stock unit activity during the six months ended June 30, 2022:
 Number of Restricted Stock UnitsWeighted Average Grant Date Fair Value
Unvested at December 31, 20211,473,949 $21.88 
Granted1,040,118 26.74 
Vested(474,224)21.26 
Forfeited/canceled(35,933)23.73 
Unvested at June 30, 20222,003,910 $24.52 
At June 30, 2022, unamortized stock compensation for service based restricted stock units was $42.5 million, with a weighted-average recognition period of 2.9 years.
Performance Based Restricted Stock Units
The following table summarizes the Company’s performance based restricted stock unit activity during the six months ended June 30, 2022:
 Number of Restricted Stock UnitsWeighted Average Grant Date Fair Value
Unvested at December 31, 202152,500 $18.73 
Granted117,208 27.50 
Vested(17,500)25.26 
Forfeited/canceled— — 
Unvested at June 30, 2022152,208 $24.73 
At June 30, 2022, unamortized stock compensation for performance based restricted stock units was $2.7 million, with a weighted-average recognition period of 1.6 years.
Share-Based Compensation
The following table sets forth total share-based compensation for the three and six months ended June 30, 2022 and 2021 (in thousands):
 Three Months Ended June 30,Six Months Ended June 30,
 2022202120222021
Research and development$3,684 $2,845 $6,852 $5,847 
Selling, general and administrative8,953 4,665 13,971 9,357 
Total$12,637 $7,510 $20,823 $15,204