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INTANGIBLE ASSETS - Amortization of Intangible Assets (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Nov. 30, 2017
Finite-Lived Intangible Assets [Line Items]      
Gross Carrying Amount $ 264,676 $ 245,802  
Accumulated Amortization (111,487) (88,602)  
Intangible assets finite-lived, net $ 153,189 $ 157,200  
Chenodal Product Rights      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 16 years 16 years  
Gross Carrying Amount $ 67,849 $ 67,849  
Accumulated Amortization (28,700) (24,451)  
Intangible assets finite-lived, net $ 39,149 $ 43,398  
Thiola License      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 15 years 15 years  
Gross Carrying Amount $ 103,992 $ 85,824 $ 5,900
Accumulated Amortization (28,117) (20,417)  
Intangible assets finite-lived, net $ 75,875 $ 65,407  
Economic Interest - U.S. revenue Cholbam      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 10 years 10 years  
Gross Carrying Amount $ 75,900 $ 75,900  
Accumulated Amortization (43,675) (36,071)  
Intangible assets finite-lived, net $ 32,225 $ 39,829  
Economic Interest - International revenue Cholbam      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 10 years 10 years  
Gross Carrying Amount $ 8,250 $ 7,544  
Accumulated Amortization (5,673) (3,585)  
Intangible assets finite-lived, net $ 2,577 $ 3,959  
Ligand License      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 11 years 11 years  
Gross Carrying Amount $ 7,900 $ 7,900  
Accumulated Amortization (4,717) (3,555)  
Intangible assets finite-lived, net $ 3,183 $ 4,345  
Manchester Customer Relationships      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 10 years 10 years  
Gross Carrying Amount $ 403 $ 403  
Accumulated Amortization (273) (232)  
Intangible assets finite-lived, net $ 130 $ 171  
Manchester Trade Name      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 1 year 1 year  
Gross Carrying Amount $ 175 $ 175  
Accumulated Amortization (175) (175)  
Intangible assets finite-lived, net $ 0 $ 0  
Internal Use Software      
Finite-Lived Intangible Assets [Line Items]      
Useful Life 5 years 5 years  
Gross Carrying Amount $ 207 $ 207  
Accumulated Amortization (157) (116)  
Intangible assets finite-lived, net $ 50 $ 91