CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Cash Flows From Operating Activities:
Net loss	$ (79,678)	$ (40,707)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	9,742	8,991
Non-cash interest expense	798	767
(Accretion) amortization of discounts/premiums on investments, net	(580)	647
Amortization of debt discount and issuance costs	4,933	325
Provision for Inventory	(358)	378
Share based compensation	11,947	10,160
ESPP Expense	345	0
Change in fair value of contingent consideration	(11,478)	5,786
Payments related to change in fair value of contingent consideration	(2,767)	(5,563)
Impairment of IPR&D intangible assets	25,500	0
Unrealized foreign currency transaction gain (loss)	14	214
Other	60	199
Changes in operating assets and liabilities, net of business acquisitions:
Accounts receivable	(2,396)	1,431
Inventory	918	(433)
Other current and non-current operating assets	(10,101)	637
Accounts payable and accrued expenses	6,305	(2,811)
Other current and non-current operating liabilities	7,195	2,485
Net cash used in operating activities	(39,601)	(17,494)
Cash Flows From Investing Activities:
Purchase of fixed assets	(21)	(601)
Cash paid for intangible assets	(7,347)	(11,389)
Proceeds from the sale/maturity of marketable securities	115,998	63,565
Purchase of marketable securities	(94,812)	(29,519)
Cash paid for investments - equity	0	(15,000)
Net cash provided by investing activities	13,818	7,056
Cash Flows From Financing Activities:
Payment of acquisition-related contingent consideration	(1,722)	(7,947)
Payment of guaranteed minimum royalty	(1,034)	(1,000)
Payment of other liability	0	(500)
Proceeds from exercise of warrants	0	2,140
Proceeds from exercise of stock options	317	6,890
Other financing activities	1,005	800
Net cash (used in) provided by financing activities	(1,434)	383
Effect of exchange rate changes on cash	1	(34)
Net change in cash and cash equivalents	(27,216)	(10,089)
Cash and cash equivalents, beginning of year	102,873	99,394
Cash and cash equivalents, end of period	$ 75,657	$ 89,305