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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001435192-09-000002.txt : 20090415
<SEC-HEADER>0001435192-09-000002.hdr.sgml : 20090415
<ACCEPTANCE-DATETIME>20090415091935
ACCESSION NUMBER:		0001435192-09-000002
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
ITEM INFORMATION:		Investment Company Act Section 3(c)
ITEM INFORMATION:		Section 3(c)(1)
FILED AS OF DATE:		20090415
DATE AS OF CHANGE:		20090415
EFFECTIVENESS DATE:		20090415

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SQUARE 1 VENTURE 1 LP
		CENTRAL INDEX KEY:			0001435192
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-118179
		FILM NUMBER:		09749900

	BUSINESS ADDRESS:	
		STREET 1:		406 BLACKWELL STREET
		STREET 2:		SUITE 240
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27701
		BUSINESS PHONE:		919-314-3802

	MAIL ADDRESS:	
		STREET 1:		406 BLACKWELL STREET
		STREET 2:		SUITE 240
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27701
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001435192</cik>
        <entityName>SQUARE 1 VENTURE 1 LP</entityName>
        <issuerAddress>
            <street1>406 BLACKWELL STREET</street1>
            <street2>SUITE 240</street2>
            <city>DURHAM</city>
            <stateOrCountry>NC</stateOrCountry>
            <zipCode>27701</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>919-314-3802</issuerPhoneNumber>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2008</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Adrian</firstName>
                <middleName></middleName>
                <lastName>Wilson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>406 Blackwell Street</street1>
                <street2>Suite 240</street2>
                <city>Durham</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27701</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>President of the General Partner of the General Partner of the Issuer</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Venture Capital Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <revenueRange>Not Applicable</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
            <item>3C</item>
            <item>3C.1</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>9999999997-08-024059</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2008-04-15</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Kalorama Capital LLC</recipientName>
                <recipientCRDNumber>104155</recipientCRDNumber>
                <associatedBDName>Elizabeth Smith Avery</associatedBDName>
                <associatedBDCRDNumber>1757864</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1050 Connecticut Ave NW</street1>
                    <street2>10th Floor</street2>
                    <city>Washington D.C.</city>
                    <stateOrCountry>DC</stateOrCountry>
                    <zipCode>20036</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AZ</state>
                    <state>CA</state>
                    <state>CO</state>
                    <state>CT</state>
                    <state>DE</state>
                    <state>DC</state>
                    <state>GA</state>
                    <state>IL</state>
                    <state>IN</state>
                    <state>IA</state>
                    <state>KS</state>
                    <state>KY</state>
                    <state>ME</state>
                    <state>MD</state>
                    <state>MA</state>
                    <state>MI</state>
                    <state>MN</state>
                    <state>MS</state>
                    <state>MO</state>
                    <state>NH</state>
                    <state>NJ</state>
                    <state>NM</state>
                    <state>NY</state>
                    <state>OH</state>
                    <state>OK</state>
                    <state>OR</state>
                    <state>PA</state>
                    <state>TN</state>
                    <state>TX</state>
                    <state>VT</state>
                    <state>VA</state>
                    <state>WA</state>
                    <state>WI</state>
                    <state>WY</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>100000000</totalOfferingAmount>
            <totalAmountSold>35450000</totalAmountSold>
            <totalRemaining>64550000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>34</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse>The listed Persons are paid directly/indirectly sale compensation (the &quot;Fee&quot;). The Fee is determined by reference to total invested by certain investors.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>The General Partner or an affiliate thereof will receive an annual management fee, payable by the Issuer in advance on the first day of each fiscal quarter, generally equal to a percentage multiplied by the subscription of each limited partner of Issuer.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>SQUARE 1 VENTURE 1 LP</issuerName>
                <signatureName>/s/ Adrian Wilson</signatureName>
                <nameOfSigner>Adrian Wilson</nameOfSigner>
                <signatureTitle>President of the General Partner of the General Partner</signatureTitle>
                <signatureDate>2009-04-15</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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