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Note I - Net Earnings Per Share (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Three months ended September 30,
 
Nine months ended September 30,
   
2018
 
2017
 
2018
 
2017
Warrants to purchase common stock
   
2,027,763
     
2,027,763
     
2,027,763
     
2,027,763
 
Awards under equity incentive plans
   
3,707,421
     
2,872,769
     
3,707,421
     
2,872,769
 
Deerfield Convertible Note
   
1,167,607
     
1,751,410
     
1,167,607
     
1,751,410
 
2021 Notes
   
5,040,914
     
5,040,914
     
5,040,914
     
5,040,914
 
Total securities excluded from the calculation of weighted average number of shares of common stock outstanding
   
11,943,705
     
11,692,856
     
11,943,705
     
11,692,856