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Note G - Stock-based Compensation (Tables)
 9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
   
Three months ended September 30,
  
Nine months ended September 30
,
   
2018
  
2017
  
2018
  
2017
Research and
development
   $
409
      $
336
     $
1,196
     $
967
  
General and administrative
    
941
      
822
      
2,813
      
2,445
  
Severance expense    
1,236
      
—
      
1,236
      
—
  
Total stock-based compensation expense    
2,586
      
1,158
      
5,245
     $
3,412