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Note M - Income Taxes (Tables)
12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
   
Year ended December 31,
 
   
2016
   
2015
   
2014
 
Federal statutory rate
   
34.00
%
   
34.00
%
   
34.00
%
Effect of:
                       
Change in valuation allowance
   
(69.31
)
   
(19.25
)
   
(32.88
)
Return to provision and deferred true-up    
(23.83
)    
     
0.36
 
Change in rate    
(14.63
)    
     
 
State tax benefit (net of federal)
   
15.64
     
4.06
     
5.96
 
Warrant liability
   
68.44
 
   
(15.28
)
   
(9.39
State research and development credit
   
0.09
     
0.03
     
0.09
 
Federal research and development credit
   
5.65
     
0.84
     
3.29
 
Amortization    
(3.15
)    
     
 
Conversion feature and put option on 2013 convertible
notes
   
 
   
(1.68
)
   
(1.26
)
Interest expense
   
     
     
0.21
 
Stock-based compensation
   
(12.71
)
   
(1.28
   
 
Other
   
(0.10
)
   
(1.42
   
(0.29
)
Federal income tax provision effective rate
   
0.09
%
   
0.02
%
   
0.09
%
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
   
December 31,
   
December 31,
   
December 31,
 
   
2016
   
2015
   
2014
 
Deferred tax assets relating to:
                       
Net operating loss carryforwards
  $
44,984
    $
26,617
    $
16,390
 
Research and development tax carryforward
   
3,166
     
2,254
     
1,793
 
Compensation
   
715
     
232
     
83
 
Total gross deferred tax assets
   
48,865
     
29,103
     
18,266
 
Deferred tax liabilities relating to:
                       
Property and equipment
   
89
     
80
     
170
 
Total gross
deferred tax liabilities
   
89
     
80
     
170
 
Deferred tax assets less liabilities
   
48,776
     
29,023
     
18,096
 
Valuation allowance
   
(48,776
)
   
(29,023
)
   
(18,096
)
Net deferred tax asset (liability)
  $
    $
    $
 
Summary of Operating Loss Carryforwards [Table Text Block]
   
Net Operating
   
Research
   
 
 
 
Year Incurred
 
Loss Carryforwards
   
Activities Credit
   
Expiration
 
2007
  $
454
    $
30
     
2027
 
2008
   
1,178
     
65
     
2028
 
2009
   
3,060
     
176
     
2029
 
2010
   
3,423
     
149
     
2030
 
2011
   
9,929
     
176
     
2031
 
2012
   
     
170
     
2032
 
2013
   
4,353
     
133
     
2033
 
2014
   
15,819
     
894
     
2034
 
2015
   
24,189
     
461
     
2035
 
2016    
 40,959
     
 912
     
 2036
 
    $
103,364
    $
3,166