United States securities and exchange commission logo





                          June 7, 2024

       R. LaDuane Clifton, MBA, CPA
       Chief Financial Officer, Secretary and Treasurer
       Zevra Therapeutics, Inc.
       1180 Celebration Boulevard, Suite 103
       Celebration, FL 34747

                                                        Re: Zevra Therapeutics,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed June 4, 2024
                                                            File No. 333-279941

       Dear R. LaDuane Clifton:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Nathan Ajiashvili, Esq.