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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001209191-10-058876.txt : 20101207
<SEC-HEADER>0001209191-10-058876.hdr.sgml : 20101207
<ACCEPTANCE-DATETIME>20101207170033
ACCESSION NUMBER:		0001209191-10-058876
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101203
FILED AS OF DATE:		20101207
DATE AS OF CHANGE:		20101207

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lund John
		CENTRAL INDEX KEY:			0001430722

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34540
		FILM NUMBER:		101237806

	MAIL ADDRESS:	
		STREET 1:		C/O NEXSTAR BROADCASTING GROUP, INC.
		STREET 2:		5215 N. O'CONNOR BLVD. SUITE 1400
		CITY:			IRVING
		STATE:			TX
		ZIP:			75039

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Unilife Corp
		CENTRAL INDEX KEY:			0001476170
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				271049354
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
		BUSINESS PHONE:		(717)938-9323

	MAIL ADDRESS:	
		STREET 1:		633 LOWTHER ROAD
		CITY:			LEWISBERRY
		STATE:			PA
		ZIP:			17339
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c09405_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-12-03</periodOfReport>

    <issuer>
        <issuerCik>0001476170</issuerCik>
        <issuerName>Unilife Corp</issuerName>
        <issuerTradingSymbol>UNIS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001430722</rptOwnerCik>
            <rptOwnerName>Lund John</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 633 LOWTHER ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LEWISBERRY</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>17339</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-12-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5.28</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>19125</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1875</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The price in Column 4 is a weighted average purchase price.  The actual prices range from $5.24 to $5.29.</footnote>
        <footnote id="F2">Owned by the spouse of John Lund.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Deborah Karlak, as Attorney-in-Fact</signatureName>
        <signatureDate>2010-12-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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