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Stockholders' Equity - Options Outstanding (Details) - $ / shares
6 Months Ended 12 Months Ended
Jun. 30, 2017
Dec. 31, 2016
Number of Shares    
Balance at the beginning of the period (in shares) 6,370,578  
Granted (in shares) 2,826,844  
Exercised (in shares) (283,995)  
Forfeited/Cancelled (in shares) (393,275)  
Balance at the end of the period (in shares) 8,520,152 6,370,578
Vested or expected to vest at the end of the period (in shares) 8,520,152  
Exercisable at the end of the period (in shares) 3,514,623  
Weighted-Average Exercise Price    
Balance at the beginning of the period (in dollars per share) $ 6.10  
Granted (in dollars per share) 4.72  
Exercised (in dollars per share) 1.25  
Forfeitures/Expirations (in dollars per share) 6.80  
Balance at the end of the period (in dollars per share) 5.78 $ 6.10
Vested or expected to vest at the end of the period (in dollars per share) 5.78  
Exercisable at the end of the period (in dollars per share) $ 5.19  
Weighted Average Remaining Contractual Term    
Options Outstanding at the end of the period 8 years 7 days 7 years 7 months 6 days
Vested or expected to vest at the end of the period 8 years 7 days  
Exercisable at the end of the period 6 years 6 months 29 days