Represents the employee stock purchase plan offering fair value reckoning percentage.

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Long-Term Incentive Program condition, increase in market capitalization

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Long term incentive program Percentage of outstanding shares

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Share based Compensation Arrangement By Share based Payment Award Equity Instruments Other Than Options Grants In Period Fair Value.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Aggregate number of common shares reserved for future issuance.

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The maximum number of common shares permitted to be issued by an entity's charter and bylaws.

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Number of shares issued pursuant to the terms of a deferred compensation arrangement.

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Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

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Amount of cost to be recognized for option under share-based payment arrangement.

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Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Number of additional shares authorized for issuance under share-based payment arrangement.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Number of shares issued under share-based payment arrangement.

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Number of shares issued during the period as a result of an employee stock purchase plan.

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Stockholders' Equity (Narrative) (Details) - USD ($) $ in Thousands			12 Months Ended
	Jan. 01, 2022	Jan. 01, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2015	Aug. 27, 2020	Dec. 31, 2016	Dec. 31, 2013	Dec. 31, 2007
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common Stock, shares authorized			200,000,000	170,000,000
Stock-based compensation expense			$ 22,987	$ 19,486
Stock options, unrecognized compensation expense			$ 100
Stock based compensation, vesting period			10 years
Journey
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			$ 4,425	2,466
Consulting Agreements [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Warrants issued			100,000
Oaktree Note [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Warrants issued							1,749,450
2007 and 2013 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation, number of shares granted			21,110,948
Stock based compensation, shares available for issuance			889,052
2013 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation, number of shares authorized						16,000,000			2,300,000
Share based compensation, additional shares authorized			3,000,000			7,700,000
2012 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			$ 100	100
Predetermined fair value percentage during offering period			85.00%
Shares purchased in connection with the ESPP offering			961,898
Number of shares available for future issuance			38,102
Long-term Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense				5,300	$ 3,800
Fair value of stock granted			$ 2,800	$ 3,300
LTIP, Percentage of outstanding shares			1.00%
Long-Term Incentive Program condition, increase in market capitalization			$ 100,000
Maximum \| 2007 and 2013 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation, shares available for issuance								22,000,000
Maximum \| 2007 Stock Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation, number of shares authorized										6,000,000
Chief Executive Officer (Dr. Rosenwald) [Member] \| Long-term Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares Granted	1,102,986	1,102,986
Executive Vice President (Mr. Weiss) [Member] \| Long-term Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares Granted	1,030,339	1,030,339
Employees and Non-Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares Granted			1,600,000	1,400,000
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			$ 4,400	$ 4,300
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			18,500	15,200
Restricted Stock Awards and Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation expense			21,900	19,500
Fair value of stock granted			7,300	$ 3,500
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense for awards other than options			$ 16,300
Number of shares Granted			3,755,972	2,330,678
Stock based compensation, vesting period			2 years 4 months 24 days
Fair value of stock granted			$ 7,000	$ 7,400
Restricted Stock [Member] \| Executives and Directors [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares Granted			3,800,000	2,300,000
Restricted Stock [Member] \| Non-Employee Directors [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Deferred compensation plan, shares issued			330,000	230,000
Restricted Stock Units (RSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense for awards other than options			$ 1,500
Number of shares Granted			1,604,945	1,405,842
Stock based compensation, vesting period			1 year 1 month 6 days
Fair value of stock granted			$ 2,100	$ 5,500
Warrants to Purchase Common Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense for awards other than options			$ 0
Performance-based Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares Granted			100,000