EX-99.2 2 dex992.htm CERTAIN SUPPLEMENTAL INFORMATION POSTED AT WWW.BMS.COM Certain supplemental information posted at www.bms.com

Exhibit 99.2

BRISTOL-MYERS SQUIBB COMPANY

NET SALES

QUARTERLY SALES TREND ANALYSIS

($ in millions)

 

    2006     2007   % Change  
    1st Qtr     2nd Qtr     6 Months     3rd Qtr     9 Months     4th Qtr     Year     1st Qtr     2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  
Net Sales                                

Pharmaceuticals

  $ 3,700     $ 3,859     $ 7,559     $ 3,154     $ 10,713     $ 3,148     $ 13,861     $ 3,457                 -7 %   -7 %

US Pharmaceuticals

    2,064       2,197       4,261       1,609       5,870       1,501       7,371       1,932                 -6 %   -6 %

Primary Care

    1,409       1,441       2,850       819       3,669       648       4,317       1,090                 -23 %   -23 %

Oncology/Virology

    419       458       877       494       1,371       525       1,896       504                 20 %   20 %

Neuroscience

    231       280       511       262       773       297       1,070       298                 29 %   29 %

Immunoscience

    5       18       23       34       57       31       88       40                 *     *  

Europe and Middle East Medicines

    1,024       1,000       2,024       886       2,910       934       3,844       916                 -11 %   -11 %

Latin America/Canada

    288       303       591       300       891       306       1,197       297                 3 %   3 %

Asia/Pacific Medicines

    279       320       599       318       917       349       1,266       289                 4 %   4 %

Nutritionals

    565       582       1,147       582       1,729       618       2,347       606                 7 %   7 %

Other Health Care

    411       430       841       418       1,259       447       1,706       413                 —       —    

ConvaTec

    230       262       492       265       757       291       1,048       254                 10 %   10 %

Medical Imaging

    181       168       349       153       502       156       658       159                 -12 %   -12 %

Total Company

  $ 4,676     $ 4,871     $ 9,547     $ 4,154     $ 13,701     $ 4,213     $ 17,914     $ 4,476                 -4 %   -4 %
    2006     2007   Basis Point Change  
    1st Qtr     2nd Qtr     6 Months     3rd Qtr     9 Months     4th Qtr     Year     1st Qtr     2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  
% of Total Sales                                

Pharmaceuticals

    79.1 %     79.2 %     79.2 %     75.9 %     78.2 %     74.7 %     77.4 %     77.2 %               (190 )   (190 )

US Pharmaceuticals

    44.1 %     45.1 %     44.6 %     38.7 %     42.8 %     35.6 %     41.1 %     43.2 %               (90 )   (90 )

Primary Care

    30.1 %     29.6 %     29.9 %     19.7 %     26.8 %     15.4 %     24.1 %     24.4 %               (570 )   (570 )

Oncology/Virology

    9.0 %     9.4 %     9.2 %     11.9 %     10.0 %     12.5 %     10.5 %     11.3 %               230     230  

Neuroscience

    4.9 %     5.7 %     5.3 %     6.3 %     5.6 %     7.0 %     6.0 %     6.7 %               180     180  

Immunoscience

    0.1 %     0.4 %     0.2 %     0.8 %     0.4 %     0.7 %     0.5 %     0.8 %               70     70  

Europe and Middle East Medicines

    21.9 %     20.5 %     21.2 %     21.3 %     21.2 %     22.2 %     21.5 %     20.5 %               (140 )   (140 )

Latin America/Canada

    6.2 %     6.2 %     6.2 %     7.2 %     6.5 %     7.3 %     6.7 %     6.6 %               40     40  

Asia/Pacific Medicines

    6.0 %     6.6 %     6.3 %     7.7 %     6.7 %     8.3 %     7.1 %     6.5 %               50     50  

Nutritionals

    12.1 %     12.0 %     12.0 %     14.0 %     12.6 %     14.7 %     13.1 %     13.5 %               140     140  

Other Health Care

    8.8 %     8.8 %     8.8 %     10.1 %     9.2 %     10.6 %     9.5 %     9.3 %               50     50  

ConvaTec

    4.9 %     5.4 %     5.2 %     6.4 %     5.5 %     6.9 %     5.8 %     5.7 %               80     80  

Medical Imaging

    3.9 %     3.4 %     3.6 %     3.7 %     3.7 %     3.7 %     3.7 %     3.6 %               (30 )   (30 )

Total Company

    100.0 %     100.0 %     100.0 %     100.0 %     100.0 %     100.0 %     100.0 %     100.0 %                

* In Excess of +/- 200%


BRISTOL-MYERS SQUIBB COMPANY

SEGMENT SALES AND COMPOSITION OF CHANGE IN SALES FOR TOTAL COMPANY

FOR THE PERIOD ENDED MARCH 31, 2007

($ in millions)

YEAR-TO-DATE

 

     Pharmaceuticals
Group
    Nutritionals     Convatec     Medical Imaging     Total
Company
 

Price Increases/(Decreases)

     —         2 %     -1 %     -3 %     —    

Foreign Exchange

     2 %     2 %     5 %     —         2 %

Volume

     -9 %     3 %     6 %     -9 %     -6 %
                                        

Total Change

     -7 %     7 %     10 %     -12 %     -4 %
                                        

Total 2007 Period to Date Sales

   $ 3,457     $ 606     $ 254     $ 159     $ 4,476  

Total 2006 Period to Date Sales

   $ 3,700     $ 565     $ 230     $ 181     $ 4,676  


BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED STATEMENT OF EARNINGS

($ in millions, except per share amounts)

 

    2006     2007   % Change  
    1st Qtr     2nd Qtr     6 Months     3rd Qtr     9 Months     4th Qtr     Year     1st Qtr     2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  

Net Sales

  $ 4,676     $ 4,871     $ 9,547     $ 4,154     $ 13,701     $ 4,213     $ 17,914     $ 4,476                 -4 %   -4 %

Cost of products sold

    1,476       1,568       3,044       1,465       4,509       1,447       5,956       1,392                 -6 %   -6 %

Marketing, selling and administrative

    1,238       1,181       2,419       1,189       3,608       1,311       4,919       1,158                 -6 %   -6 %

Advertising and product promotion

    295       352       647       286       933       418       1,351       269                 -9 %   -9 %

Research and development

    750       740       1,490       756       2,246       821       3,067       807                 8 %   8 %

Provision for restructuring, net

    1       3       4       2       6       53       59       37                 *     *  

Litigation (income)/charges, net

    (21)       (14)       (35)       (9)       (44)       346       302       —                   100 %   100 %

Gain on sale of business and product asset

    (200)       —         (200)       —         (200)       —         (200)       —                   100 %   100 %

Equity in net income of affiliates

    (93)       (125)       (218)       (118)       (336)       (138)       (474)       (126)                 -35 %   -35 %

Other expense/(income), net

    37       56       93       (34)       59       240       299       22                 -41 %   -41 %
                                                                                       

Total expenses

    3,483       3,761       7,244       3,537       10,781       4,498       15,279       3,559                 2 %   2 %
                                                                                       

Earnings/(Loss) Before Minority Interest and Income Taxes

    1,193       1,110       2,303       617       2,920       (285)       2,635       917                 -23 %   -23 %

Provision/(Benefit) for income taxes

    328       256       584       193       777       (167)       610       86                 -74 %   -74 %

Minority interest, net of taxes

    151       187       338       86       424       16       440       141                 -7 %   -7 %
                                                                                       

Net Earnings/(Loss)

  $ 714     $ 667     $ 1,381     $ 338     $ 1,719     $ (134)     $ 1,585       690                 -3 %   -3 %
                                                                                       

Interest expense on conversion of convertible debt bonds, net of tax

    8       8       16       9       25       —   (1)     —   (2)     9                  

Net Earnings/(Loss) used for diluted earnings per common share calculation

  $ 722     $ 675     $ 1,397     $ 347     $ 1,744     $ (134) (1)   $ 1,585 (2)     699                  
                                                                               

Diluted Earnings/(Loss) per Common Share**

  $ 0.36     $ 0.34     $ 0.70     $ 0.17     $ 0.88     $  (0.07) (1)   $ 0.81 (2)   $ 0.35                 -3 %   -3 %

Average Common Shares Outstanding - Diluted

    1,988       1,994       1,992       1,992       1,991       1,961 (1)     1,963 (2)     1,997                 —       —    

Dividends declared per common share

  $ 0.28     $ 0.28     $ 0.56     $ 0.28     $ 0.84     $ 0.28     $ 1.12     $ 0.28                 —       —    
    2006     2007   Basis Point Change  
    1st Qtr     2nd Qtr     6 Months     3rd Qtr     9 Months     4th Qtr     Year     1st Qtr     2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  

% of Net Sales

                               

Gross Margin

    68.4 %     67.8 %     68.1 %     64.7 %     67.1 %     65.7 %     66.8 %     68.9 %               50     50  

Cost of products sold

    31.6 %     32.2 %     31.9 %     35.3 %     32.9 %     34.3 %     33.2 %     31.1 %               (50)     (50)  

Marketing, selling and administrative

    26.5 %     24.2 %     25.3 %     28.6 %     26.3 %     31.1 %     27.5 %     25.9 %               (60)     (60)  

Advertising and product promotion

    6.3 %     7.2 %     6.8 %     6.9 %     6.8 %     9.9 %     7.5 %     6.0 %               (30)     (30)  

Research and development

    16.0 %     15.2 %     15.6 %     18.2 %     16.4 %     19.5 %     17.1 %     18.0 %               200     200  

Total expenses

    74.5 %     77.2 %     75.9 %     85.1 %     78.7 %     106.8 %     85.3 %     79.5 %               500     500  

Earnings/(Loss) Before Minority Interest and Income Taxes

    25.5 %     22.8 %     24.1 %     14.9 %     21.3 %     -6.8 %     14.7 %     20.5 %               (500)     (500)  

Net Earnings/(Loss)

    15.3 %     13.7 %     14.5 %     8.1 %     12.5 %     -3.2 %     8.8 %     15.4 %               10     10  

Other Ratios

                               

Effective Tax Rate

    27.5 %     23.1 %     25.4 %     31.3 %     26.6 %     58.6 %     23.1 %     9.4 %                
                                                                               
    2006     2007   % Change  
    1st Qtr     2nd Qtr     6 Months     3rd Qtr     9 Months     4th Qtr     Year     1st Qtr     2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  

Other (Income)/Expense, net

                               

Interest expense

  $ 116     $ 124     $ 240     $ 130     $ 370     $ 128     $ 498     $ 109                 -6 %   -6 %

Interest income

    (62)       (65)       (127)       (74)       (201)       (73)       (274)       (53)                 15 %   15 %

Foreign exchange transaction (gains)/losses

    (12)       23       11       (11)       —         6       6       8                 167 %   167 %

Other, net

    (5)       (26)       (31)       (79)       (110)       179       69       (42)                 *     *  
                                                                                       
  $ 37     $ 56     $ 93     $ (34)     $ 59     $ 240     $ 299     $ 22                 -41 %   -41 %
                                                                                       

* in excess of +/- 200%
** amounts may not calculate due to rounding differences between continuing and discontinued operations.
(1) as a result of the Q4 2006 net loss, Diluted Average Common Shares Outstanding and Loss per Common Share are equal to Basic Average Common Shares Outstanding and Loss per Common Share.
(2) assumed interest amount and the assumed conversion of convertible debt are not used for Diluted Earnings per Common Share calculation as the impact of convertible debt is anti-dilutive.


BRISTOL-MYERS SQUIBB COMPANY

WORLDWIDE NET SALES BY PRODUCT

QUARTERLY SALES TREND ANALYSIS

($ in millions)

 

    2006   2007   % Change  
    1st Qtr   2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   1st Qtr   2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  

Total Company

  $ 4,676   $ 4,871   $ 9,547   $ 4,154   $ 13,701   $ 4,213   $ 17,914   $ 4,476               -4 %   -4 %

PHARMACEUTICALS

    3,700     3,859     7,559     3,154     10,713     3,148     13,861     3,457               -7 %   -7 %

Cardiovascular

    1,917     1,907     3,824     1,239     5,063     1,093     6,156     1,475               -23 %   -23 %

Plavix

    986     1,145     2,131     630     2,761     496     3,257     938               -5 %   -5 %

Pravachol

    536     323     859     192     1,051     146     1,197     135               -75 %   -75 %

Avapro/ Avalide

    233     280     513     277     790     307     1,097     270               16 %   16 %

Coumadin

    55     55     110     53     163     57     220     46               -16 %   -16 %

Virology

    468     524     992     532     1,524     580     2,104     590               26 %   26 %

Reyataz

    207     236     443     233     676     255     931     263               27 %   27 %

Sustiva Franchise***

    175     193     368     201     569     222     791     226               29 %   29 %

Baraclude

    11     14     25     22     47     36     83     45               *     *  

Oncology

    361     401     762     399     1,161     394     1,555     355               -2 %   -2 %

Erbitux

    138     172     310     175     485     167     652     160               16 %   16 %

Taxol

    147     149     296     137     433     130     563     111               -24 %   -24 %

Sprycel

    —       —       —       11     11     14     25     21               —       —    

Affective (Psychiatric) Disorders

    323     376     699     354     1,053     404     1,457     408               26 %   26 %

Abilify**

    283     324     607     313     920     362     1,282     366               29 %   29 %

Immunoscience

    5     18     23     34     57     32     89     41               *     *  

Orencia

    5     18     23     34     57     32     89     41               *     *  

Other Pharmaceuticals

                               

Efferalgan

    68     62     130     62     192     74     266     81               19 %   19 %

NUTRITIONALS

    565     582     1,147     582     1,729     618     2,347     606               7 %   7 %

Enfamil

    237     253     490     246     736     271     1,007     254               7 %   7 %

Enfagrow

    67     59     126     69     195     67     262     72               7 %   7 %

OTHER HEALTH CARE

    411     430     841     418     1,259     447     1,706     413               —       —    

CONVATEC

    230     262     492     265     757     291     1,048     254               10 %   10 %

Ostomy

    123     141     264     139     403     151     554     130               6 %   6 %

Wound Therapeutics

    98     107     205     113     318     123     441     107               9 %   9 %

MEDICAL IMAGING

    181     168     349     153     502     156     658     159               -12 %   -12 %

Cardiolite

    103     105     208     97     305     103     408     99               -4 %   -4 %

* In excess of +/- 200%
** Includes alliance revenue from the co-promotional agreement with Otsuka Pharmaceutical Co., Ltd.
*** Beginning in the third quarter of 2006, the Sustiva Franchise includes sales of branded Sustiva, as well as revenue of bulk efavirenz included in the combination therapy, Atripla. Atripla is sold through a joint venture with Gilead Sciences, Inc.


BRISTOL-MYERS SQUIBB COMPANY

DOMESTIC* NET SALES BY PRODUCT

QUARTERLY SALES TREND ANALYSIS

($ in millions)

 

    2006   2007   % Change    

% Change in U.S.

Total Prescription****

 
    1st Qtr   2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   1st Qtr   2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD     Qtr vs. Qtr     YTD vs. YTD  

Total Company

  $ 2,638   $ 2,806   $ 5,444   $ 2,170   $ 7,614   $ 2,115   $ 9,729   $ 2,505               -5 %   -5 %    

PHARMACEUTICALS

    2,076     2,205     4,281     1,619     5,900     1,517     7,417     1,944               -6 %   -6 %    

Cardiovascular

    1,341     1,330     2,671     752     3,423     616     4,039     1,045               -22 %   -22 %    

Plavix

    850     988     1,838     474     2,312     343     2,655     787               -7 %   -7 %   -28 %   -28 %

Pravachol

    302     128     430     73     503     50     553     57               -81 %   -81 %   -86 %   -86 %

Avapro/ Avalide

    139     167     306     159     465     182     647     163               17 %   17 %   -1 %   -1 %

Coumadin

    47     46     93     45     138     48     186     38               -19 %   -19 %   -17 %   -17 %

Virology

    259     270     529     292     821     327     1,148     319               23 %   23 %    

Reyataz

    119     122     241     129     370     144     514     143               20 %   20 %   17 %   17 %

Sustiva Franchise*****

    108     115     223     128     351     144     495     144               33 %   33 %   25 %   25 %

Baraclude

    9     9     18     14     32     18     50     17               89 %   89 %   127 %   127 %

Oncology

    159     187     346     201     547     195     742     182               14 %   14 %    

Erbitux

    136     172     308     173     481     165     646     158               16 %   16 %   N/A     N/A  

Taxol

    4     4     8     2     10     2     12     4               —       —       N/A     N/A  

Sprycel

    —       —       —       11     11     11     22     10               —       —       N/A     N/A  

Affective (Psychiatric) Disorders

    237     286     523     266     789     302     1,091     305               29 %   29 %    

Abilify**

    231     267     498     260     758     294     1,052     293               27 %   27 %   14 %   14 %

Immunoscience

    5     18     23     34     57     31     88     40               * **   * **    

Orencia

    5     18     23     34     57     31     88     40               * **   * **   N/A     N/A  

Other Pharmaceuticals

                                   

Efferalgan

    —       —       —       —       —       —       —       —                 —       —       N/A     N/A  

NUTRITIONALS

    247     282     529     267     796     295     1,091     274               11 %   11 %    

Enfamil

    155     174     329     169     498     190     688     171               10 %   10 %   N/A     N/A  

Enfagrow

    —       —       —       —       —       —       —       —                 —       —       N/A     N/A  

OTHER HEALTH CARE

    231     226     457     215     672     232     904     214               -7 %   -7 %    

CONVATEC

    73     85     158     84     242     101     343     78               7 %   7 %    

Ostomy

    34     41     75     39     114     45     159     34               —       —       N/A     N/A  

Wound Therapeutics

    30     34     64     36     100     43     143     32               7 %   7 %   N/A     N/A  

MEDICAL IMAGING

    158     141     299     131     430     131     561     136               -14 %   -14 %    

Cardiolite

    91     91     182     86     268     90     358     87               -4 %   -4 %   N/A     N/A  

* This table presents Total Company sales on a legal entity source basis and segment and product sales on a country management reported basis. As a result, the sum of segment sales does not tie to Total Company sales.
** Includes alliance revenue from the co-promotional agreement with Otsuka Pharmaceutical Co., Ltd.
*** In excess of +/- 200%
**** The estimated total U.S. prescription change for the retail and mail order channels are calculated based on Next-Generation Prescription Services (NGPS) version 2.0 data on a weighted-average basis. NGPS data is provided by IMS Health, a supplier of market research for the pharmaceutical industry. The weighted-average basis reflects the fact that mail order prescriptions include a greater volume of product supplied compared to retail prescriptions, which on average are 90 days for mail order and 30 days for retail. The calculation is derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions.
***** Beginning in the third quarter of 2006, the Sustiva Franchise includes sales of branded Sustiva, as well as revenue of bulk efavirenz included in the combination therapy, Atripla. Atripla is sold through a joint venture with Gilead Sciences, Inc. The change in U.S. total prescriptions growth for the Sustiva Franchise includes both branded Sustiva and Atripla prescription units.


BRISTOL-MYERS SQUIBB COMPANY

INTERNATIONAL* NET SALES BY PRODUCT

QUARTERLY SALES TREND ANALYSIS

($ in millions)

 

    2006   2007   % Change  
    1st Qtr    2nd Qtr    6 Months    3rd Qtr    9 Months    4th Qtr    Year    1st Qtr   2nd Qtr   6 Months   3rd Qtr   9 Months   4th Qtr   Year   Qtr vs. Qtr     YTD vs. YTD  

Total Company

  $ 2,038    $ 2,065    $ 4,103    $ 1,984    $ 6,087    $ 2,098    $ 8,185    $ 1,971               -3 %   -3 %

PHARMACEUTICALS

    1,624      1,654      3,278      1,535      4,813      1,631      6,444      1,513               -7 %   -7 %

Cardiovascular

    576      577      1,153      487      1,640      477      2,117      430               -25 %   -25 %

Plavix

    136      157      293      156      449      153      602      151               11 %   11 %

Pravachol

    234      195      429      119      548      96      644      78               -67 %   -67 %

Avapro/ Avalide

    94      113      207      118      325      125      450      107               14 %   14 %

Coumadin

    8      9      17      8      25      9      34      8               —       —    

Virology

    209      254      463      240      703      253      956      271               30 %   30 %

Reyataz

    88      114      202      104      306      111      417      120               36 %   36 %

Sustiva Franchise****

    67      78      145      73      218      78      296      82               22 %   22 %

Baraclude

    2      5      7      8      15      18      33      28                    ***        ***

Oncology

    202      214      416      198      614      199      813      173               -14 %   -14 %

Erbitux

    2      —        2      2      4      2      6      2               —       —    

Taxol

    143      145      288      135      423      128      551      107               -25 %   -25 %

Sprycel

    —        —        —        —        —        3      3      11               —       —    

Affective (Psychiatric) Disorders

    86      90      176      88      264      102      366      103               20 %   20 %

Abilify**

    52      57      109      53      162      68      230      73               40 %   40 %

Immunoscience

    —        —        —        —        —        1      1      1               —       —    

Orencia

    —        —        —        —        —        1      1      1               —       —    

Other Pharmaceuticals

                                      

Efferalgan

    68      62      130      62      192      74      266      81               19 %   19 %

NUTRITIONALS

    318      300      618      315      933      323      1,256      332               4 %   4 %

Enfamil

    82      79      161      77      238      81      319      83               1 %   1 %

Enfagrow

    67      59      126      69      195      67      262      72               7 %   7 %

OTHER HEALTH CARE

    180      204      384      203      587      215      802      199               11 %   11 %

CONVATEC

    157      177      334      181      515      190      705      176               12 %   12 %

Ostomy

    89      100      189      100      289      106      395      96               8 %   8 %

Wound Therapeutics

    68      73      141      77      218      80      298      75               10 %   10 %

MEDICAL IMAGING

    23      27      50      22      72      25      97      23               —       —    

Cardiolite

    12      14      26      11      37      13      50      12               —       —    

* This table presents Total Company sales on a legal entity source basis and segment and product sales on a country management reported basis. As a result, the sum of segment sales does not tie to Total Company sales.
** Includes alliance revenue from the co-promotional agreement with Otsuka Pharmaceutical Co., Ltd.
*** In excess of +/- 200%
**** Beginning in the third quarter of 2006, the Sustiva Franchise includes sales of branded Sustiva, as well as revenue of bulk efavirenz included in the combination therapy, Atripla. Atripla is sold through a joint venture with Gilead Sciences, Inc.


BRISTOL-MYERS SQUIBB COMPANY

U.S. PHARMACEUTICALS NET SALES

EXCLUDING ESTIMATED IMPACT OF LAUNCH OF GENERIC CLOPIDOGREL BISULFATE

($ in millions)

 

     2007    2006    % Change
     Q1    Q1    Qtr vs. Qtr
U.S Pharmaceuticals Net Sales         

U.S Pharmaceuticals Net Sales as Reported

   $1,932    $2,064    -6%

Estimated Impact of Launch of Generic Clopidogrel Bisulfate

   300 to 350    —      —  

U.S Pharmaceuticals Net Sales Excluding the Estimated

        
              

Impact of Launch of Generic Clopidogrel Bisulfate

   $2,232 to $2,282    $2,064    8% to 11%
              


BRISTOL-MYERS SQUIBB COMPANY

GROSS MARGIN

EXCLUDING SPECIFIED ITEMS

($ in millions)

 

     2007  
     Q1                       TOTAL YEAR  

Net Sales

   $ 4,476           $ 4,476  
                      

Gross Profit

          

Gross Profit

   $ 3,084           $ 3,084  

Specified items*

     16             16  
                      

Gross Profit Excluding Specified Items

   $ 3,100           $ 3,100  
                      

Gross Margin %

     68.9 %           68.9 %

Specified items*

     0.4 %           0.4 %
                      

Gross Margin Excluding Specified Items

     69.3 %           69.3 %
                      
     2006  
     Q1     Q2     Q3     Q4     TOTAL YEAR  

Net Sales

   $ 4,676     $ 4,871     $ 4,154     $ 4,213     $ 17,914  
                                        

Gross Profit

          

Gross Profit

   $ 3,200     $ 3,303     $ 2,689     $ 2,766     $ 11,958  

Specified items*

     46       20       72       29       167  
                                        

Gross Profit Excluding Specified Items

   $ 3,246     $ 3,323     $ 2,761     $ 2,795     $ 12,125  
                                        

Gross Margin %

          

Gross Margin %

     68.4 %     67.8 %     64.7 %     65.6 %     66.8 %

Specified items*

     1.0 %     0.4 %     1.7 %     0.7 %     0.9 %
                                        

Gross Margin Excluding Specified Items

     69.4 %     68.2 %     66.4 %     66.3 %     67.7 %
                                        

* Please refer to the Specified Item - QTD tab for detail of specified items.


BRISTOL-MYERS SQUIBB COMPANY

RESEARCH AND DEVELOPMENT EXPENSES

EXCLUDING SPECIFIED ITEMS

($ in millions)

 

     2007
     Q1                   TOTAL YEAR

Research and Development Expenses

   $             807             $ 807

Specified items*

     80               80
                      

Research and Development Expenses Excluding Specified Items

   $ 727             $ 727
                      
     2006
     Q1    Q2    Q3    Q4    TOTAL YEAR

Research and Development Expenses

   $ 750    $             740    $             756    $             821    $ 3,067

Specified items*

     18      1      17      49      85
                                  

Research and Development Expenses Excluding Specified Items

   $ 732    $ 739    $ 739    $ 772    $ 2,982
                                  

* Please refer to the Specified Item - QTD tab for detail of specified items.


BRISTOL-MYERS SQUIBB COMPANY

EFFECTIVE TAX RATE

EXCLUDING SPECIFIED ITEMS

($ in millions)

 

     2007  
     Q1                       TOTAL YEAR  

Provision for Income Taxes

          

Provision for Income Taxes

   $ 86           $ 86  

Specified items*

     79             79  
                      

Provision for Income Taxes Excluding Specified Items

   $ 165           $ 165  
                      

Earnings Before Minority Interest and Provision for Income Taxes

   $ 917           $ 917  

Earnings Before Minority Interest and Provision for Income Taxes Excluding Specified Items

   $ 1,050           $ 1,050  

Effective Tax Rate

          

Effective Tax Rate

     9.4 %           9.4 %

Effective Tax Rate Excluding Specified Items

     15.7 %           15.7 %
     2006  
     Q1     Q2     Q3     Q4     TOTAL YEAR  

Provision for Income Taxes

          

Provision/(Benefit) for Income Taxes

   $ 328     $ 256     $ 193     $ (167 )   $ 610  

Specified items*

     (49 )     (3 )     (34 )     196       110  
                                        

Provision for Income Taxes Excluding Specified Items

   $ 279     $ 253     $ 159     $ 29     $ 720  
                                        

Earnings/(Loss) Before Minority Interest and Provision for Income Taxes

   $ 1,193     $ 1,110     $ 617     $ (285 )   $ 2,635  

Earnings Before Minority Interest and Provision for Income Taxes Excluding Specified Items

   $ 1,081     $ 1,120     $ 670     $ 425     $ 3,296  

Effective Tax Rate

          

Effective Tax Rate

     27.5 %     23.1 %     31.3 %     58.6 %     23.1 %

Effective Tax Rate Excluding Specified Items

     25.8 %     22.6 %     23.7 %     6.8 %     21.8 %

* Please refer to the Specified Item - QTD tab for detail of specified items.


BRISTOL-MYERS SQUIBB COMPANY

EARNINGS BEFORE MINORITY INTEREST AND INCOME TAXES

EXCLUDING SPECIFIED ITEMS

($ in millions)

 

     2007  
     Q1                       TOTAL YEAR  

Earnings Before Minority Interest and Provision for Income Taxes

   $ 917           $ 917  

Specified items:

          

Upfront and milestone payments

     80             80  

Downsizing and streamlining of worldwide operations

     37             37  

Accelerated depreciation

     16             16  
                      

Subtotal

     133             133  
                      

Earnings Before Minority Interest and Provision for Income Taxes Excluding Specified Items

   $ 1,050           $ 1,050  
                      
     2006  
     Q1     Q2     Q3     Q4     TOTAL YEAR  

Earnings / (Loss) Before Minority Interest and Provision for Income Taxes

   $ 1,193     $ 1,110     $ 617     $ (285 )   $ 2,635  

Specified items:

          

Gain on sale of product asset

     (200 )     —         —         —         (200 )

Litigation matters

     40       (14 )     (29 )     353       350  

Insurance recoveries

     (21 )     —         (9 )     (7 )     (37 )

Downsizing and streamlining of worldwide operations / other

     69       24       91       131       315  

Debt retirement costs

     —         —         —         220       220  

Claim for damages

     —         —         —         13       13  
                                        

Subtotal

     (112 )     10       53       710       661  
                                        

Earnings Before Minority Interest and Provision for Income Taxes Excluding Specified Items

   $ 1,081     $ 1,120     $ 670     $ 425     $ 3,296  
                                        


BRISTOL-MYERS SQUIBB COMPANY

DILUTED EARNINGS PER COMMON SHARE

EXCLUDING SPECIFIED ITEMS

 

     2007  
     Q1                      TOTAL YEAR *  

Diluted Earnings per Common Share

   $ 0.35            $ 0.35  

Specified items:

           

Upfront payments

     0.03              0.03  

Downsizing and streamlining of worldwide operations

     0.01              0.01  

Accelerated depreciation

     0.01              0.01  

Change in estimate for taxes on a prior year specified item

     (0.02 )            (0.02 )
                       

Subtotal

     0.03              0.03  
                       

Diluted Earnings per Common Share Excluding Specified Items

   $ 0.38            $ 0.38  
                       
     2006  
     Q1     Q2    Q3     Q4     TOTAL YEAR *  

Diluted Earnings / (Loss) per Common Share

   $ 0.36     $ 0.34    $ 0.17     $ (0.07 )   $ 0.81  

Specified items:

           

Gain on sale of product asset

     (0.06 )     —        —         —         (0.06 )

Litigation matters

     0.01       —        (0.01 )     0.14       0.14  

Insurance recoveries

     (0.01 )     —        —         —         (0.01 )

Downsizing and streamlining of worldwide operations / other

     0.02       0.01      0.04       0.05       0.12  

Debt retirement costs

     —         —        —         0.07       0.07  

Tax item

     —         —        0.02       —         0.02  
                                       

Subtotal

     (0.04 )     0.01      0.05       0.26       0.28  
                                       

Diluted Earnings per Common Share Excluding Specified Items

   $ 0.32     $ 0.35    $ 0.22     $ 0.19     $ 1.09  
                                       

* quarterly amounts may not add to the annual total due to rounding of individual calculations.


BRISTOL-MYERS SQUIBB COMPANY

SPECIFIED ITEMS

FOR THE THREE MONTHS ENDED MARCH 31, 2007 AND 2006

($ in millions)

Three months ended March 31, 2007

 

     Cost of
products sold
   Research and
development
   Provision for
restructuring, net
   Total                         

Upfront payments

   $ —      $ 80    $ —      $ 80           

Downsizing and streamlining of worldwide operations

     —        —        37      37           

Accelerated depreciation

     16      —        —        16           
                                      
   $ 16    $ 80    $ 37      133           
                                

Income taxes on items above

              (40 )         

Change in estimate for taxes on a prior year specified item

              (39 )         
                          

Reduction to Net Earnings

            $ 54           
                          

Three months ended March 31, 2006

                    
     Cost of
products sold
   Research and
development
   Sales Force    Provision for
restructuring
and other items,
net
    Litigation
settlement
income
    Other expense,
net
   Gain on sale
of product
asset
    Total  

Litigation Matters:

                    

Insurance recovery

   $ —      $ —      $ —      $ —       $ (21 )   $ —      $ —       $ (21 )

Commercial litigation

     —        —        —        —         —         40      —         40  
                                                            
     —        —        —        —         (21 )     40      —         19  

Other:

                    

Accelerated depreciation and asset impairment

     46      —        4      —         —         —        —         50  

Upfront and milestone payments

     —        18      —        —         —         —        —         18  

Downsizing and streamlining of worldwide operations

     —        —        —        1       —         —        —         1  

Gain on sale of product asset

     —        —        —        —         —         —        (200 )     (200 )
                                                            
   $ 46    $ 18    $ 4    $ 1     $ (21 )   $ 40    $ (200 )     (112 )
                                                      

Income taxes on items above

                       48  

Minority interest, net of taxes

                       (13 )
                          

Increase to Net Earnings

                     $ (77 )
                          


BRISTOL-MYERS SQUIBB COMPANY

SELECT BALANCE SHEET INFORMATION

($ in millions)

 

     March 31,
2006
   June 30,
2006
   September 30,
2006
   December 31,
2006
    March 31,
2007
   June 30,
2007
   September 30,
2007
   December 31,
2007

Cash, cash equivalents and marketable debt securities

   $ 5,281    $ 5,357    $ 5,505    $ 4,013     $ 4,012    $ —      $ —      $ —  

Short-term borrowings

     234      189      630      187       241      —        —        —  

Long-term debt

     8,278      8,239      7,837      7,248       7,132      —        —        —  
                                                        

Net debt

   $ 3,231    $ 3,071    $ 2,962    $ 3,422     $ 3,361    $ —      $ —      $ —  
                                                        

Receivables, net of allowances

   $ 3,236    $ 3,326    $ 2,945    $ 3,247     $ 3,381    $ —      $ —      $ —  

Stockholders’ equity

     11,556      11,712      11,589      9,991  (1)     10,261      —        —        —  

Capital expenditures and capitalized software (for the quarter ended)

     202      160      199      224       202         

(1) Includes the impact of the adoption of SFAS 158, “Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans - an amendment of FASB Statements No. 87, 88, 106 and 132(R)”


BRISTOL-MYERS SQUIBB COMPANY

2007 FULL YEAR PROJECTED DILUTED EPS

EXCLUDING PROJECTED SPECIFIED ITEMS

 

     Full Year 2007  

Projected Diluted Earnings per Common Share

   $ 1.24 to $1.34  

Projected Specified Items:

  

Upfront and milestone payments

     0.05  

Downsizing and streamlining of worldwide operations

     0.03  

Change in estimate for taxes on a prior year specified item

     (0.02 )
        

Total

     0.06  
        

Projected Diluted Earnings per Common Share Excluding Specified Items

   $ 1.30 to $1.40  
        

Gross Margin/Research and Development/Tax Rate Projections Excluding Specified Items

Gross margin on a GAAP basis for the three months ended March 31, 2007 was 68.9%, which included specified items of $16 million and had a 0.4% adverse impact on gross margin in aggregate. On a non-GAAP basis, for the three months ended March 31, 2007 gross margin was 69.3%. On a non-GAAP basis, based on historical trends in 2006 and the first quarter of 2007 the Company projects gross margin for the full year 2007 to be at least 100 basis points higher than 2006. There is no reasonably accessible or reliable comparable GAAP measure for this forward-looking information on gross margin. See Gross Margin non comparable tab.

Research and development expenses on a GAAP basis for the three months ended March 31, 2007 were $807 million, which included specified items of $80 million. On a non-GAAP basis, for the three months ended March 31, 2007 research and development expenses were $727 million. On a non-GAAP basis, based on historical trends in 2006 and the first quarter of 2007 the Company projects research and development expenses for the full year 2007 to increase in the mid to upper single digit range compared to 2006. There is no reasonably accessible or reliable comparable GAAP measure for this forward-looking information on research and development. See R&D non comparable tab.

The effective tax rate on a GAAP basis for the three months ended March 31, 2007 was 9.4%, which included specified items of $79 million in the tax provision, and had a 6.3% favorable impact on the effective tax rate in aggregate. On a non-GAAP basis, the three months ended March 31, 2007 effective tax rate was 15.7%. On a non-GAAP basis, based on historical trends in 2006 and the first quarter of 2007 the Company projects effective tax rate for the full year 2007 to be in the 20% range. There is no reasonably accessible or reliable comparable GAAP measure for this forward-looking information on the tax rate. See Tax Rate non comparable tab.

The GAAP results for the full year 2007 would include specified items that may occur and impact results. These specified items could include charges and recoveries relating to significant legal proceedings, debt retirement costs and other charges related to new transactions, upfront and milestone payments, copromotion or alliance charges and charges for in-process research and development related to new external development transactions, gains or losses from asset disposals, restructuring activities and significant tax events. For a fuller discussion of certain of the litigation and other matters that could impact full year GAAP results, as well as the use of non-GAAP financial information, see Bristol-Myers Squibb Company Reports Financial Results For The First Quarter of 2007, April 26, 2007, including “2007 Guidance” and “Use of Non-GAAP Financial Information” therein.


BRISTOL-MYERS SQUIBB COMPANY

ESTIMATED MONTHS ON HAND OF TOP 15 U.S. PHARMACEUTICAL PRODUCTS

IN THE U.S. WHOLESALER DISTRIBUTION CHANNEL

The following tables sets forth, for each of the Company’s top 15 pharmaceutical products (based on 2006 annual net sales) sold by the Company’s U.S. Pharmaceuticals business, the U.S. Pharmaceuticals net sales and the estimated number of months on hand of the applicable product in the U.S. wholesaler distribution channel for the quarters ended March 31, 2007 and 2006 and December 31, 2006 and 2005.

 

    March 31, 2007   December 31, 2006   March 31, 2006   December 31, 2005
    Net Sales   Months on Hand   Net Sales   Months on Hand   Net Sales   Months on Hand   Net Sales   Months on Hand
    (Dollars in Millions)       (Dollars in Millions)       (Dollars in Millions)       (Dollars in Millions)    

Abilify (total revenue)

  $ 293   0.4   $ 294   0.5   $ 231   0.5   $ 175   0.6

Avapro/Avalide

    163   0.4     182   0.5     139   0.4     168   0.6

Baraclude

    17   0.6     18   0.7     9   1.0     4   0.7

Coumadin

    38   0.7     48   0.8     47   0.6     50   0.8

Erbitux (a)

    158   0.3     165   0.4     136   —       121   —  

Glucophage Franchise

    21   0.6     16   0.7     25   0.7     29   0.7

Kenalog

    18   0.5     24   0.8     23   0.7     23   0.9

Orencia (b)

    40   0.3     31   0.4     5   0.9     —     —  

Paraplatin

    5   13.8     6   5.8     7   1.2     5   0.9

Plavix

    787   0.6     343   0.6     850   0.4     906   0.6

Pravachol

    57   0.6     50   0.6     302   0.4     366   0.6

Reyataz

    143   0.7     144   0.7     119   0.6     110   0.5

Sprycel

    10   0.7     11   1.4     —     —       —     —  

Sustiva Franchise (c) (total revenue)

    144   0.7     144   0.7     108   0.5     102   0.6

Zerit

    12   0.6     19   0.9     19   0.7     21   0.8

For all products other than Erbitux and Orencia, the Company determines the above months on hand estimates by dividing the estimated amount of the product in the U.S. wholesaler distribution channel by the estimated amount of out-movement of the product from the U.S. wholesaler distribution channel over a period of 31 days, all calculated as described below. Factors that may influence the Company’s estimates include generic competition, seasonality of products, wholesaler purchases in light of increases in wholesaler list prices, new product launches, new warehouse openings by wholesalers and new customer stockings by wholesalers. In addition, such estimates are calculated using third-party data, which represent their own record-keeping processes and as such, may also reflect estimates.

Estimates of product in the wholesaler distribution channel and out-movement are based on weekly information received directly from third-parties, and excludes any inventory held by intermediaries such as retailers and hospitals, and excludes goods in transit to such wholesalers. The Company determines the amount of out-movement of a product over a period of 31 days by using the most recent out-movement of a product as provided by these third parties, adjusted to reflect the Company’s estimate of goods in transit to these wholesalers. The Company estimates the amount of goods in transit by using information provided by these wholesalers with respect to their open orders and the Company’s records of sales to these wholesalers with respect to such open orders.

(a) In the first and second quarter of 2006, the Company sold Erbitux to intermediaries (such as wholesalers and specialty oncology distributors) and shipped Erbitux directly to the end-users of the product who are the customers of those intermediaries. Beginning in the third quarter of 2006, the Company expanded its distribution model to include two distributors who then held Erbitux inventory. One additional distributor was added for Erbitux in the first quarter of 2007. The Company recognizes revenue upon such shipment consistent with its revenue recognition policy. The above estimate of months on hand was calculated by dividing the inventories of Erbitux held by the distributors for their own accounts as reported by the distributors as of the end of the quarter by the out-movements of the product reported by the distributors over the last 31 day period. The inventory levels reported by the distributors are a product of their record-keeping process.

(b) Orencia was launched in February 2006. From launch through the second quarter, the Company distributed Orencia through an exclusive distribution arrangement with a single distributor. Following approval of the supplemental Biologics License Application (sBLA) that allows a third party to manufacture Orencia at an additional site, the exclusive distribution arrangement terminated on July 17, 2006 and the Company expanded its distribution network for ORENCIA to multiple distributors. The above estimates of months on hand was calculated by dividing the inventories of Orencia held by these distributors at the end of the quarter by the out-movement of the product over the last 31 day period, as reported by these distributors. The inventory on hand and out-movements reported by these distributors are a product of the distributors’ own record-keeping process.

(c) Beginning in the third quarter of 2006, the Sustiva Franchise includes sales of Sustiva, as well as revenue of bulk efavirenz included in the combination therapy, Atripla. The estimated months on hand of the product in the U.S. wholesale distribution channel only include branded Sustiva inventory.


U.S. Pharmaceuticals

Estimated End-User Demand

The following tables set forth for each of the Company’s top 15 pharmaceutical products (based on 2006 annual net sales) sold by the U.S. Pharmaceuticals business, for the three months ended March 31, 2007 compared to the same periods in the prior year: (i) changes in reported U.S. net sales for the period; (ii) estimated total U.S. prescription change for the retail and mail order channels calculated by the Company based on NGPS version 2.0 data on a weighted average basis; and (iii) the estimated U.S. therapeutic category share of the applicable product calculated by the Company based on NGPS version 2.0 data on a weighted-average basis. Prior year prescription data has been adjusted to conform to the NGPS version 2.0 data.

 

    

Three Months Ended

March 31, 2007

   

Month Ended

March 31, 2007

 
    

Change

in U.S.

Net Sales(a)

   

Change in U.S.

Total Prescriptions(b)

   

Estimated TRx

Therapeutic

Category Share (b, c)

 

ABILIFY* (total revenue)

   27 %   14 %   12 %

AVAPRO*/AVALIDE*

   17     (1 )   13  

BARACLUDE

   89     127     25  

COUMADIN

   (19 )   (17 )   14  

ERBITUX* (d)

   16     N/A     N/A  

GLUCOPHAGE* Franchise

   (16 )   (39 )   1  

KENALOG (e)

   (22 )   N/A     N/A  

ORENCIA(d)

   * *   N/A     N/A  

PARAPLATIN (d)

   (29 )   N/A     N/A  

PLAVIX*

   (7 )   (28 )   65  

PRAVACHOL

   (81 )   (86 )   1  

REYATAZ (f)

   20     17     19  

SPRYCEL (g)

   —       —       5  

SUSTIVA Franchise (f, h) (total revenue)

   33     25     34  

ZERIT

   (37 )   (26 )   4  
    

Three Months Ended

March 31, 2006

   

Month Ended

March 31, 2006

 
    

Change

in U.S.

Net Sales(a)

   

Change in U.S.

Total Prescriptions(b)

   

Estimated TRx

Therapeutic

Category Share (b, c)

 

ABILIFY* (total revenue)

   43 %   29 %   12 %

AVAPRO*/AVALIDE*

   36     4     15  

BARACLUDE

   —       —       15  

COUMADIN

   12     (28 )   18  

ERBITUX* (d)

   56     N/A     N/A  

GLUCOPHAGE* Franchise

   (36 )   (48 )   1  

KENALOG (e)

   109     N/A     N/A  

ORENCIA (d)

   —       N/A     N/A  

PARAPLATIN (d)

   (53 )   N/A     N/A  

PLAVIX*

   26     13     87  

PRAVACHOL

   17     (17 )   6  

REYATAZ (f)

   29     16     18  

SPRYCEL (g)

   —       —       —    

SUSTIVA (f)

   5     2     31  

ZERIT

   (27 )   (35 )   6  

(a) Reflects percentage change in net sales in dollar terms, including change in average selling prices and wholesaler buying patterns.


(b) Derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions.
(c) The therapeutic categories are determined by the Company as those products considered to be in direct competition with the Company’s own products. The products listed above compete in the following therapeutic categories: ABILIFY* (antipsychotics), AVAPRO*/AVALIDE* (angiotensin receptor blockers), BARACLUDE (oral antiviral agent), COUMADIN (warfarin), ERBITUX* (oncology), GLUCOPHAGE* Franchise (oral antidiabetics), KENALOG (intra-articular/intramuscular steroid), ORENCIA (fusion protein), PARAPLATIN (carboplatin), PLAVIX* (antiplatelet agents), PRAVACHOL (HMG CoA reductase inhibitors), REYATAZ (antiretrovirals - third agents excluding NORVIR* and TRIZIVIR*), SPRYCEL (TKIs for leukemia), SUSTIVA Franchise (antiretrovirals - third agents excluding NORVIR* and TRIZIVIR*) and ZERIT (nucleoside reverse transcriptase inhibitors).
(d) ERBITUX*, PARAPLATIN and ORENCIA are parenterally administered products and do not have prescription-level data as physicians do not write prescriptions for these products. The Company believes therapeutic category share information provided by third parties for these products may not be reliable and accordingly, none is presented here.
(e) The Company does not have prescription level data because the product is not dispensed through a retail pharmacy. The Company believes therapeutic category share information provided by third parties for this product may not be reliable and accordingly, none is presented here.
(f) REYATAZ and the SUSTIVA Franchise have been recalculated as a percentage share of antiretrovirals – third agents excluding NORVIR* and TRIZIVIR*.
(g) SPRYCEL was launched in the U.S. in July 2006.
(h) Beginning in the third quarter of 2006, SUSTIVA Franchise (total revenue) includes sales of SUSTIVA, as well as revenue of bulk efavirenz included in the combination therapy, ATRIPLA*. The therapeutic category share information and change in U.S. total prescriptions growth for SUSTIVA Franchise (antiretrovirals – third agents excluding NORVIR* and TRIZIVIR*) includes both branded SUSTIVA and ATRIPLA* prescription units.
** In excess of 200%.

The Company is reporting REYATAZ’s estimated TRx category share within the antiretrovirals - third agents (excluding NORVIR* and TRIZIVIR*) category rather than the protease inhibitors (excluding NORVIR*) category. The Company believes that the antiretrovirals - third agents (excluding NORVIR* and TRIZIVIR*) category more closely reflects the use of protease inhibitors, which has evolved and competes with other products within the antiretrovirals - third agents (excluding NORVIR* and TRIZIVIR*) category. The historical trends of growth in REYATAZ’s estimated TRx category share between the two categories are not materially different.

The estimated prescription change data and estimated therapeutic category share reported throughout this Form 10-Q only include information from the retail and mail order channels and do not reflect information from other channels, such as hospitals, institutions and long-term care, among others. The data provided by IMS are a product of IMS’ own record-keeping processes and are themselves estimates based on sampling procedures, subject to the inherent limitations of estimates based on sampling.


Estimated Inventory Months on Hand in the Distribution Channel

The following tables set forth for each of the Company’s top 15 pharmaceutical products (based on 2006 annual net sales) sold by the Company’s U.S. Pharmaceuticals business, the U.S. Pharmaceuticals net sales and the estimated number of months on hand of the applicable product in the U.S. wholesaler distribution channel for the quarters ended March 31, 2007 and 2006 and December 31, 2006 and 2005.

 

      March 31, 2007    March 31, 2006

(Dollars in Millions)

   Net Sales    Months on Hand    Net Sales    Months on Hand

ABILIFY* (total revenue)

   $ 293    0.4    $ 231    0.5

AVAPRO*/AVALIDE*

     163    0.4      139    0.4

BARACLUDE

     17    0.6      9    1.0

COUMADIN

     38    0.7      47    0.6

ERBITUX*

     158    0.3      136    —  

GLUCOPHAGE* Franchise

     21    0.6      25    0.7

KENALOG

     18    0.5      23    0.7

ORENCIA

     40    0.3      5    0.9

PARAPLATIN

     5    13.8      7    1.2

PLAVIX*

     787    0.6      850    0.4

PRAVACHOL

     57    0.6      302    0.4

REYATAZ

     143    0.7      119    0.6

SPRYCEL

     10    0.7      —      —  

SUSTIVA Franchise (a) (total revenue)

     144    0.7      108    0.5

ZERIT

     12    0.6      19    0.7
     December 31, 2006    December 31, 2005

(Dollars in Millions)

   Net Sales    Months on Hand    Net Sales    Months on Hand

ABILIFY* (total revenue)

   $ 294    0.5    $ 175    0.6

AVAPRO*/AVALIDE*

     182    0.5      168    0.6

BARACLUDE

     18    0.7      4    0.7

COUMADIN

     48    0.8      50    0.8

ERBITUX*

     165    0.4      121    —  

GLUCOPHAGE* Franchise

     16    0.7      29    0.7

KENALOG

     24    0.8      23    0.9

ORENCIA

     31    0.4      —      —  

PARAPLATIN

     6    5.8      5    0.9

PLAVIX*

     343    0.6      906    0.6

PRAVACHOL

     50    0.6      366    0.6

REYATAZ

     144    0.7      110    0.5

SPRYCEL

     11    1.4      —      —  

SUSTIVA Franchise (a) (total revenue)

     144    0.7      102    0.6

ZERIT

     19    0.9      21    0.8

(a) Beginning in the third quarter of 2006, the SUSTIVA Franchise includes sales of SUSTIVA, as well as revenue of bulk efavirenz included in the combination therapy, ATRIPLA*. The estimated months on hand of the product in the U.S. wholesale distribution channel only include branded SUSTIVA inventory.

In October 2004, the U.S. pediatric exclusivity period for PARAPLATIN expired. The resulting entry of multiple generic competitors for PARAPLATIN led to a significant decrease in demand for PARAPLATIN, which in turn led to the months on hand of the product in the U.S. wholesaler distribution channel exceeding one month on hand at March 31, 2007, December 31, 2006 and March 31, 2006. The estimated value of PARAPLATIN inventory in the U.S. wholesaler distribution channel over one month on hand was approximately $0.4 million at March 31, 2007, $0.6 million at December 31, 2006 and $0.9 million at March 31, 2006. The Company no longer produces PARAPLATIN for the U.S. market and will continue to monitor PARAPLATIN wholesaler inventory levels until they have been depleted.


SPRYCEL was launched in the U.S. in July 2006. Consistent with customary practice at the time of a new product launch, the Company’s U.S. wholesalers built inventories of the product to meet expected demand, and at December 31, 2006, the estimated value of SPRYCEL inventory in the U.S. wholesaler distribution channel exceeded one month on hand by approximately $1.4 million. As of March 31, 2007, SPRYCEL inventory in the U.S. wholesaler distribution channel has been worked down to less than one month on hand.

For all products other than ERBITUX* and ORENCIA, the Company determines the above months on hand estimates by dividing the estimated amount of the product in the U.S. wholesaler distribution channel by the estimated amount of out-movement of the product from the U.S. wholesaler distribution channel over a period of 31 days, all calculated as described below. Factors that may influence the Company’s estimates include generic competition, seasonality of products, wholesaler purchases in light of increases in wholesaler list prices, new product launches, new warehouse openings by wholesalers and new customer stockings by wholesalers. In addition, such estimates are calculated using third-party data, which represent their own record-keeping processes and as such, may also reflect estimates.

The Company maintains inventory management agreements (IMAs) with most of its U.S. Pharmaceuticals wholesalers, which account for nearly 100% of total gross sales of U.S. pharmaceutical products. Under the current terms of the IMAs, the Company’s three largest wholesaler customers provide the Company with weekly information with respect to inventory levels of product on hand and the amount of out-movement of products. These three wholesalers accounted for nearly 90% of total gross sales of U.S. pharmaceutical products in the first quarter of 2007. The inventory information received from these wholesalers excludes inventory held by intermediaries to whom they sell, such as retailers and hospitals, and excludes goods in transit to such wholesalers. The Company uses the information provided by these three wholesalers as of the Friday closest to quarter end to calculate the amount of inventory on hand for these wholesalers at the applicable quarter end. This amount is then increased by the Company’s estimate of goods in transit to these wholesalers based on the Company’s records of sales to these wholesalers, which have not been reflected in the weekly data provided by the wholesalers. Under the Company’s revenue recognition policy, sales are recorded when substantially all the risks and rewards of ownership are transferred, which in the U.S. Pharmaceuticals business is generally when product is shipped. In such cases, goods in transit to a wholesaler are owned by the applicable wholesaler and, accordingly, are reflected in the calculation of inventories in the wholesaler distribution channel. The Company determines the out-movement of a product from these wholesalers over a period of 31 days by using the most recent four weeks of out-movement of a product as provided by these wholesalers and extrapolating such amount to a 31 day basis. The Company estimates for each product, inventory levels on hand and out-movements for all its U.S. Pharmaceuticals business wholesaler customers, by adjusting the three largest wholesalers’ inventory levels and out-movements by a factor that approximates the other remaining wholesalers’ percentage share of total gross sales for such product in the U.S. In addition, the Company receives inventory information from these other wholesalers on a selective basis for certain key products.

The Company’s U.S. Pharmaceuticals business through the IMAs discussed above, has arrangements with substantially all of its direct wholesaler customers and requires those wholesalers to maintain inventory at levels that are no more than one month of their demand.

ORENCIA was launched in February 2006. From launch through the second quarter, the Company distributed ORENCIA through an exclusive distribution arrangement with a single distributor. Following approval of the supplemental Biologics License Application that allows a third party to manufacture ORENCIA at an additional site, the exclusive distribution arrangement terminated on July 17, 2006 and the Company expanded its distribution network for ORENCIA to multiple distributors. The above estimates of months on hand was calculated by dividing the inventories of ORENCIA held by these distributors at the end of the quarter by the out-movement of the product over the last 31 day period, as reported by these distributors. The inventory on hand and out-movements reported by these distributors are a product of the distributors’ own record-keeping processes.

 


In the first and second quarter of 2006, the Company sold ERBITUX* to intermediaries (such as wholesalers and specialty oncology distributors) and shipped ERBITUX* directly to the end-users of the product who are the customers of those intermediaries. Beginning in the third quarter of 2006, the Company expanded its distribution model to include two distributors who then held ERBITUX* inventory. One additional distributor was added for ERBITUX* in the first quarter of 2007. The Company recognizes revenue upon such shipment consistent with its revenue recognition policy.

The above estimate of months on hand was calculated by dividing the inventories of ERBITUX* held by the distributors for their own accounts as reported by the distributors as of the end of the quarter by the out-movements of the product reported by the distributors over the last 31 day period. The inventory levels reported by the distributors are a product of their record-keeping process.


International Pharmaceuticals, Nutritionals and Other Health Care

The following table sets forth for each of the Company’s key pharmaceutical products and other growth drivers sold by the Company’s International Pharmaceuticals reporting segment, including the top 15 pharmaceutical products sold in the Company’s major non-U.S. countries (based on 2006 net sales), and for each of the key products sold by the other reporting segments listed below, the percentage change in the Company’s estimated ultimate patient/consumer demand for the months of March 2007 and December 2006 compared to the same period in the prior year.

 

    

% Change in Demand on a

Constant U.S. Dollar Basis

 
    

March 2007

vs. March 2006

   

December 2006

vs. December 2005

 

International Pharmaceuticals

    

ABILIFY* (total revenue)

   5     15  

AVAPRO*/AVALIDE*

   5     6  

BARACLUDE

   23     * *

BUFFERIN*

   0     11  

CAPOTEN

   (6 )   (16 )

DAFALGAN

   0     5  

EFFERALGAN

   (1 )   2  

MAXIPIME

   (4 )   (23 )

MONOPRIL

   (8 )   (10 )

ORENCIA

   * *   N/A  

PERFALGAN

   1     17  

PLAVIX*

   1     (8 )

PRAVACHOL

   (1 )   (63 )

REYATAZ

   16     23  

SPRYCEL

   N/A     N/A  

SUSTIVA Franchise (total revenue)

   3     4  

TAXOL® (paclitaxel)

   (5 )   (18 )

VIDEX/VIDEX EC

   11     (33 )

Nutritionals

    

ENFAMIL/ENFAGROW

   6     6  

NUTRAMIGEN

   4     17  

Other Health Care

    

ConvaTec

    

Ostomy

   5     —    

Wound Therapeutics

   3     5  

Medical Imaging

    

CARDIOLITE

   (8 )   (5 )

** In excess of 200%


Estimated Inventory Months on Hand in the Distribution Channel

The following table sets forth for each of the Company’s key products sold by the reporting segments listed below, the net sales of the applicable product for each of the quarters ended March 31, 2007, December 31, 2006, March 31, 2006, and December 31, 2005, and the estimated number of months on hand of the applicable product in the direct customer distribution channel for the reporting segment as of the end of each of the four quarters. The estimates of months on hand for key products described below for the International Pharmaceuticals reporting segment are based on data collected for all of the Company’s significant business units outside of the U.S. Also described further below is information on non-key product(s) where the amount of inventory on hand at direct customers is more than approximately one month and the impact is not de minimis. For the other reporting segments, estimates are based on data collected for the U.S. and all significant business units outside of the U.S.

 

     March 31, 2007    December 31, 2006

Dollars in Millions

   Net Sales   

Months

On Hand

   Net Sales   

Months

On Hand

International Pharmaceuticals

           

ABILIFY* (total revenue)

   $ 73    0.6    $ 68    0.7

AVAPRO*/AVALIDE*

     107    0.5      125    0.6

BARACLUDE

     28    0.7      18    0.8

BUFFERIN*

     24    0.5      32    0.5

CAPOTEN

     26    0.8      31    0.8

DAFALGAN

     44    1.2      40    1.0

EFFERALGAN

     81    1.1      74    0.7

MAXIPIME

     29    0.5      33    0.6

MONOPRIL

     36    0.8      35    0.9

ORENCIA

     1    0.3      1    —  

PERFALGAN

     58    0.5      54    0.5

PLAVIX*

     151    0.5      153    0.6

PRAVACHOL

     78    0.6      96    0.8

REYATAZ

     120    0.9      111    1.0

SPRYCEL

     11    0.4      3    0.5

SUSTIVA Franchise (a) (total revenue)

     82    0.5      78    0.5

TAXOL® (paclitaxel)

     107    0.7      128    0.7

VIDEX/VIDEX EC

     27    1.1      29    1.4

Nutritionals

           

ENFAMIL/ENFAGROW

     326    0.8      338    0.9

NUTRAMIGEN

     52    0.9      54    1.0

Other Health Care

           

ConvaTec

           

Ostomy

     130    0.9      151    1.0

Wound Therapeutics

     107    0.9      123    1.0

Medical Imaging

           

CARDIOLITE

     99    0.7      103    0.9

(a) Beginning in the third quarter of 2006, the SUSTIVA Franchise includes sales of SUSTIVA, as well as revenue of bulk efavirenz included in the combination therapy, ATRIPLA*. The estimated months on hand of the product in the distribution channel only include branded SUSTIVA inventory.


     March 31, 2006    December 31, 2005

Dollars in Millions

   Net Sales   

Months

on Hand

   Net Sales   

Months

on Hand

International Pharmaceuticals

           

ABILIFY* (total revenue)

   $ 52    0.6    $ 49    0.6

AVAPRO*/AVALIDE*

     94    0.5      109    0.6

BARACLUDE

     2    1.1      1    —  

BUFFERIN*

     22    0.6      36    0.7

CAPOTEN

     35    0.8      38    0.8

DAFALGAN

     37    1.4      34    1.2

EFFERALGAN

     68    1.2      74    1.0

MAXIPIME

     40    0.8      48    0.8

MONOPRIL

     46    1.1      43    0.9

ORENCIA

     —      —        —      —  

PERFALGAN

     46    0.6      43    0.6

PLAVIX*

     136    0.5      155    0.6

PRAVACHOL

     234    1.5      218    0.8

REYATAZ

     88    0.6      78    0.6

SPRYCEL

     —      —        —      —  

SUSTIVA

     67    0.5      68    0.6

TAXOL® (paclitaxel)

     143    0.6      176    0.8

VIDEX/VIDEX EC

     31    0.8      34    0.9

Nutritionals

           

ENFAMIL/ENFAGROW

     304    0.9      330    1.0

NUTRAMIGEN

     48    1.0      48    1.1

Other Health Care

           

ConvaTec

           

Ostomy

     123    0.9      145    1.0

Wound Therapeutics

     98    0.9      112    0.9

Medical Imaging

           

CARDIOLITE

     103    0.8      100    1.0

The above months on hand information represents the Company’s estimates of aggregate product level inventory on hand at direct customers divided by the expected demand for the applicable product. Expected demand is the estimated ultimate patient/consumer demand calculated based on estimated end-user consumption or direct customer out-movement data over the most recent 31 day period or other reasonable period. Factors that may affect the Company’s estimates include generic competition, seasonality of products, direct customer purchases in light of price increases, new product or product presentation launches, new warehouse openings by direct customers, new customer stockings by direct customers and expected direct customer purchases for governmental bidding situations.

The Company relies on a variety of methods to calculate months on hand for these reporting segments. Where available, the Company relies on information provided by third parties to determine estimates of aggregate product level inventory on hand at direct customers and expected demand. For the reporting segments listed above; however, the Company has limited information on direct customer product level inventory, end-user consumption and direct customer out-movement data. Further, the quality of third-party information, where available, varies widely. In some circumstances, such as the case with new products or seasonal products, such historical end-user consumption or out-movement information may not be available or applicable. In such cases, the Company uses estimated prospective demand. In cases where direct customer product level inventory, ultimate patient/consumer demand or out-movement data do not exist or are otherwise not available, the Company has developed a variety of other methodologies to calculate estimates of such data, including using such factors as historical sales made to direct customers and third-party market research data related to prescription trends and end-user demand.


As of March 31, 2006, BARACLUDE, an antiviral product, had approximately 1.1 months of inventory on hand at direct customers. The level of inventory on hand was due primarily to stocking of the product in support of the recent launch in China.

As of March 31, 2007, March 31, 2006, and December 31, 2005, DAFALGAN, an analgesic product sold principally in Europe, had approximately 1.2, 1.4 and 1.2 months of inventory on hand, respectively, at direct customers. The level of inventory on hand was due primarily to private pharmacists purchasing DAFALGAN approximately once every eight weeks and the seasonality of the product.

As of March 31, 2007 and March 31, 2006, EFFERALGAN, an analgesic product sold principally in Europe, had approximately 1.1 and 1.2 months of inventory on hand respectively, at direct customers. The level of inventory on hand was due primarily to private pharmacists purchasing EFFERALGAN approximately once every eight weeks and the seasonality of the product.

As of March 31, 2006, MONOPRIL, a cardiovascular product, had approximately 1.1 months of inventory on hand at direct customers. The level of inventory on hand was due primarily to supply of the product in support of its inclusion in a government program in Russia.

As of March 31, 2006, PRAVACHOL, a cardiovascular product, had approximately 1.5 months of inventory on hand at direct customers. The increased level of inventory on hand was due primarily to an increase in orders from a significant direct customer in France.

As of March 31, 2007 and December 31, 2006, VIDEX/VIDEX EC, an antiviral product, had approximately 1.1 and 1.4 months of inventory on hand, respectively, at direct customers. The increased level of inventory on hand was due primarily to government purchasing patterns in Brazil. The Company is contractually obligated to provide VIDEX/VIDEX EC to the Brazilian government upon placement of an order for product by the government. Under the terms of the contract, the Company has no control over the inventory levels relating to such orders.

As of December 31, 2005, NUTRAMIGEN, infant nutritional products sold principally in the U.S., had approximately 1.1 months of inventory on hand at direct customers. The level of inventory on hand at the end of the quarter ended December 31, 2005 was due primarily to holiday stocking by retailers.

The Company continuously seeks to improve the quality of its estimates of months on hand of inventories held by its direct customers including thorough review of its methodologies and processes for calculation of these estimates and review and analysis of its own and third parties’ data used in such calculations. The Company expects that it will continue to review and refine its methodologies and processes for calculation of these estimates and will continue to review and analyze its own and third parties’ data in such calculations. The Company also has and will continue to take steps to expedite the receipt and processing of data for the non-U.S. Pharmaceuticals business.