REVENUE - Disaggregation of Revenue by Product and Region (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue from External Customer [Line Items]
Total Revenues	$ 46,385	$ 42,518	$ 26,145
United States
Revenue from External Customer [Line Items]
Total Revenues	29,214	26,577	15,342
Europe
Revenue from External Customer [Line Items]
Total Revenues	10,687	9,853	6,266
Rest of World
Revenue from External Customer [Line Items]
Total Revenues	5,632	5,457	4,013
Other
Revenue from External Customer [Line Items]
Total Revenues	852	631	524
Revlimid
Revenue from External Customer [Line Items]
Total Revenues	12,821	12,106	1,299
Eliquis
Revenue from External Customer [Line Items]
Total Revenues	10,762	9,168	7,929
Opdivo
Revenue from External Customer [Line Items]
Total Revenues	7,523	6,992	7,204
Pomalyst/Imnovid
Revenue from External Customer [Line Items]
Total Revenues	3,332	3,070	322
Orencia
Revenue from External Customer [Line Items]
Total Revenues	3,306	3,157	2,977
Sprycel
Revenue from External Customer [Line Items]
Total Revenues	2,117	2,140	2,110
Yervoy
Revenue from External Customer [Line Items]
Total Revenues	2,026	1,682	1,489
Abraxane
Revenue from External Customer [Line Items]
Total Revenues	1,181	1,247	166
Reblozyl
Revenue from External Customer [Line Items]
Total Revenues	551	274	0
Empliciti
Revenue from External Customer [Line Items]
Total Revenues	334	381	357
Abecma
Revenue from External Customer [Line Items]
Total Revenues	164	0	0
Zeposia
Revenue from External Customer [Line Items]
Total Revenues	134	12	0
Breyanzi
Revenue from External Customer [Line Items]
Total Revenues	87	0	0
Inrebic
Revenue from External Customer [Line Items]
Total Revenues	74	55	5
Onureg
Revenue from External Customer [Line Items]
Total Revenues	73	17	0
Mature and other brands
Revenue from External Customer [Line Items]
Total Revenues	$ 1,900	$ 2,217	$ 2,287